6 replies to this topic

[shifter]

First off, not interested in wasting money taking 20-30mg every day but I am curious if somebody did take stupid high doses so that both A and B types were inhibited from breaking down and they did not eat any tyramine containing foods or supplements like 5htp, samE or anything warning against taking with MAOs, what the result would be on the person and what they will feel.

Only interested in its life span extending capabilities so 5mg is my max anyway.

[winston]

That's what antidepressant doses are like. It's been used in some studies without very shocking or dangerous results I believe.

I don't think tyramine foods are really a risk, I ate plenty the time I tried 40mg deprenyl and didn't get any of the side affects one would expect. The dep itself just felt like too much dopamine. Similar to adderall somewhat, but quite unpleasant. YMMV though

[Animal]

It would be essentially the same as any other non-specific MAOI, look it up.

[brain]

This isn't all very different than taking the EMSAM patch, which delivers the dosage transdermally and so isn't degraded during first pass metabolism, which is why much lower doses are used in the patch to achieve the same effect that 35 - 80 mg of oral deprenyl would. I have tried taking 5mg/day BID sublingually to achieve the antidepressant effect. It is not a "clean" feeling antidepressant, I couldn't sleep, felt wirey and anxious and unlike myself. I crashed very hard when I took 10 mg one day. I lowered the dosage to 7 mg for a while (roughly equal to 35 mg of oral deprenyl) and that worked pretty well for me. If someone did want to do this, I would recommend that you try around 40 mg/day in two divided dosages or 8mg sublingually in two divided dosages. Deprenyl (but not sublingual deprenyl) will drastically increase neurogenesis in the hippocampus even without MAO-A inhibiting dosages. It increases BDNF and GDNF. I take 10mg a day in a single dose and also take liquid rhodiola extract, which strongly inhibits MAO-A (reversibly, and apparently by as much as 95%).

Edit: Btw, EMSAM doesn't seem to be responded to very well in general. It's inferior to the other MAOIs in efficacy but tends to have much fewer side effects. If the deprenyl is taken sublingually, there probably isn't much risk for hypertensive crises from tyramine containing foods, but I still avoided them for the most part. I, like most EMSAM users I've heard of, didn't like or respond well to the nonselective deprenyl dosages.

Edited by brain, 25 March 2010 - 08:17 AM.

[shifter]

I take 5mg of the liquid selegiline (selepryl) and leave it under my tongue for a minute before swallowing. In order for something to be sublingually delivered, should there be nothing left to swallow? Is 1 minute long enough?

I didn't know that about the Rhodiola being that strong of an MAO, but I take that as a 500mg capsule every couple of days.

I don't think my diet has any or much tyramine in it, so probably not a problem there.

But am I getting any benefit from leaving the selepryl under my tongue for a minute? Need to wait longer? Or just getting a foul taste in my mouth for nothing!!

This isn't all very different than taking the EMSAM patch, which delivers the dosage transdermally and so isn't degraded during first pass metabolism, which is why much lower doses are used in the patch to achieve the same effect that 35 - 80 mg of oral deprenyl would. I have tried taking 5mg/day BID sublingually to achieve the antidepressant effect. It is not a "clean" feeling antidepressant, I couldn't sleep, felt wirey and anxious and unlike myself. I crashed very hard when I took 10 mg one day. I lowered the dosage to 7 mg for a while (roughly equal to 35 mg of oral deprenyl) and that worked pretty well for me. If someone did want to do this, I would recommend that you try around 40 mg/day in two divided dosages or 8mg sublingually in two divided dosages. Deprenyl (but not sublingual deprenyl) will drastically increase neurogenesis in the hippocampus even without MAO-A inhibiting dosages. It increases BDNF and GDNF. I take 10mg a day in a single dose and also take liquid rhodiola extract, which strongly inhibits MAO-A (reversibly, and apparently by as much as 95%).

Edit: Btw, EMSAM doesn't seem to be responded to very well in general. It's inferior to the other MAOIs in efficacy but tends to have much fewer side effects. If the deprenyl is taken sublingually, there probably isn't much risk for hypertensive crises from tyramine containing foods, but I still avoided them for the most part. I, like most EMSAM users I've heard of, didn't like or respond well to the nonselective deprenyl dosages.

[panhedonic]

I know this is an old thread, but where did you get the sublingual/oral conversions from? As far as I know, there's no study that clearly sets up a conversion rate. I would be very interested in knowing where you got that from.

Also, can you kindly point me to the study where non-sublingual only would increase neurogenesis in the hippocampus?

thanks.

This isn't all very different than taking the EMSAM patch, which delivers the dosage transdermally and so isn't degraded during first pass metabolism, which is why much lower doses are used in the patch to achieve the same effect that 35 - 80 mg of oral deprenyl would. I have tried taking 5mg/day BID sublingually to achieve the antidepressant effect. It is not a "clean" feeling antidepressant, I couldn't sleep, felt wirey and anxious and unlike myself. I crashed very hard when I took 10 mg one day. I lowered the dosage to 7 mg for a while (roughly equal to 35 mg of oral deprenyl) and that worked pretty well for me. If someone did want to do this, I would recommend that you try around 40 mg/day in two divided dosages or 8mg sublingually in two divided dosages. Deprenyl (but not sublingual deprenyl) will drastically increase neurogenesis in the hippocampus even without MAO-A inhibiting dosages. It increases BDNF and GDNF. I take 10mg a day in a single dose and also take liquid rhodiola extract, which strongly inhibits MAO-A (reversibly, and apparently by as much as 95%).

Edit: Btw, EMSAM doesn't seem to be responded to very well in general. It's inferior to the other MAOIs in efficacy but tends to have much fewer side effects. If the deprenyl is taken sublingually, there probably isn't much risk for hypertensive crises from tyramine containing foods, but I still avoided them for the most part. I, like most EMSAM users I've heard of, didn't like or respond well to the nonselective deprenyl dosages.

[chemicalambrosia]

Brainjuice, check out the study in this linked post: http://www.longecity...yl/#entry178928