Im definitly not a biochem, i only really know a couple of systems.
The chemistry of the brain is insane, there are so many pathways and variable peptides, theres 2000 g-protien coupled receptors.....
Pyridoxine seems to be a carry molecule in energy pathways, it will activate and supply energy, to effect mulitpule outcomes. This is mainly achieved via Pyridoxal phosphate but also Pyridoxal Sulfate(notice pyritinol is two of these molecules bound together). Sulfates behave very similarly to phosphates but are probally lower energy, with slower kenetics and potential act on completely different systems.
I would assume that your use of Pyridoxal distruped your system maybe through competitive inhibtion of pyridoxal phosphates, but it could be a down regulation of the production pyridoxal sulphate, it could also be over production of pyridoxal phosphates during the acute phase of use(neuropathy). The effects will be mediated downstream maybe in....or downstream of these respective systems.
Wikipedia, effects of pyridoxal phosphates
3.2Gluconeogenesis
3.3 Lipid metabolism
4.1 Amino acid metabolism
4.2 Neurotransmitter synthesis
4.3 Histamine synthesis
4.4 Hemoglobin synthesis and function
4.5 Gene expression
Furthermore there is strong evidence that while pyridoxine at low doses is safe and benefical, there is also strong evidence that it can cause acute neuropathies that usually fix on cessation. That is why it is recommend to not to take more than 100mg of B6, I assume your dose of pyritinol was much higher? It might be a bad idea taking one and not the other, and i would assume you shouldnt take more than 100mg for both pyrindoxines.
Some Ideas about what to do about it,
D2 agonist are used for libido enhancement
Go see an endocrinologist, get fully hormone tests and maybe start testosterone therapy.
Get lots of really challenging exercise
New Girl?
Experiencing novelty is really good for everybody, it increase intelligence quickly, so try something new whether its job,friends,personality,location,learning...... Become a Yes man(That movie has alot of truth in it)
It could also be caused by something else random
I couldnt think what NALT was, Definitly the first and last time Im going to help some guy with his libido
Edited by haha, 29 April 2010 - 11:34 AM.