65 replies to this topic

[gavrilov]

I am going to return to this central theme as it is of paramount importance to the premise for Human Selection but for the moment two things all who read to this point.  As you need to be familiar with the serious importance of evolution's relationship to genetic theory I suggest if you haven't already, please read this article by Gavrilov/Gavrilova.  I invite them to comment on this subject as well because I believe one or both of them to be present in our membership.

Yes, I am here now, thank you.

This interesting discussion may receive a fresh start again, because of a new book specifically covering the subject of DNA mutations and aging in great detail. This book is now listed on the very top here:

New Books on Aging and Longevity Studies
http://longevity-sci.../new-books.html

Hope it helps,

[John Schloendorn]

Hi Leonid,
Excellent, so Vijg joins the circle of book-writing aging researchers! How technical is this book? Is it written for laypeople or other workers in the field?

[gavrilov]

This is a professional book, which could be sufficiently well understood by an intelligent motivated lay person

[olaf.larsson]

DNA, In My Opinion, Is The Cause Of Aging

Most DNA defefect associated syndromes do not lead to aging. When you are exposed to mutagens the first thing you think is not "Im going to age faster" but "My risk of getting cancer increases". Why is it so if aging really is dna damage??

[maestro949]

My own personal theory is that it has more to do with what might appear to be DNA damage but is really changes in gene expression do to the changing state of the cell as a whole. e.g repair mechanisms might have their expression levels up or downregulated due to one of numerous signalling, metabolic, mutational or damage related physiological changes. I tend to favor the theories that take into account the entire network of, well, networks. i.e. The Network Theory of Aging in conjunction with Reliability Theory

[gavrilov]

Hi Leonid,
Excellent, so Vijg joins the circle of book-writing aging researchers! How technical is this book? Is it written for laypeople or other workers in the field?

Hi John,

One more comment in addition to my prior response:

Check page 268 of this book for an interesting discussion of the new High Initial Damage Load (HIDL) hypothesis "that early development produces a high load of initial damage."

Kind regards,