We have been recommending morning administration of resveratrol for higher bioavailability, and because evening administration disrupts sleep cycles via interaction with CLOCK genes interfering with circadian rhythms.
I've been self-experimenting with melatonin to see if this would overcome the effect. I've found that taking 1 mg melatonin, and 400 mg 99% resveratrol at bedtime, allows me to sleep normally without the insomnia resveratrol induces in some people when they use it at night. I cannot measure my blood levels, but morning stiffness has decreased, though I still don't jump out of bed like I did when I was ten.
I also take 400mg resveratrol before breakfast.
This could be a way to increase one's average blood levels of resveratrol to enhance its effect.
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Mol Nutr Food Res. 2009 Feb 4th
Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers.
Almeida L, Vaz-da-Silva M, Falcão A, Soares E, Costa R, Loureiro AI, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, Soares-da-Silva P.
(Bioavailability higher with morning administration)
PMID: 19194969
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Biosci Biotechnol Biochem. 2008 Nov;72(11):3038-40. Epub 2008 Nov 7.
Resveratrol regulates circadian clock genes in Rat-1 fibroblast cells.
Oike H, Kobori M.
National Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki, Japan. oike@affrc.go.jp
Abstract
Circadian clocks, especially peripheral clocks, can be strongly entrained by daily feedings, but few papers have reported the effects of food components on circadian rhythm. The effects of resveratrol, a natural polyphenol, on circadian clocks of Rat-1 cells were analyzed. A dose of 100 muM resveratrol, which did not show cytotoxicity, regulated the expression of clock genes Per1, Per2, and Bmal1.
PMID: 18997419
Edited by maxwatt, 22 August 2010 - 02:23 PM.