Could the mixed studies on Quercetin be due to the fact that it inhibits CD38 ?
Certainly the inhibition of cd38 is responsible for some of the effects of quercetin.
CD38 is not necessarily a bad thing. You can live without it -- some organisms, including people, cannot produce it, due to a mutation -- but that causes a lot of health problems.
However, the downregulation of cd38 might be a good thing, especially in conjunction with resveratrol, as I suggested in the very active thread on the important recent study on mitochondria in the aging cell. See the many references in:
http://www.longecity...-strikes-again/
This is the Gomes, et. al. paper in Cell:
http://www.cell.com/...8674(13)01521-3
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
At issue is the NAD+ / NADH ratio. In old cells, NADH begins to predominate, resulting in mitochondrial malfunction. Resveratrol promotes an NAD+ synthesis pathway, while CD38, as an "NAD-ase" catalyses the reduction of NAD+ . So resveratrol and quercetin in combination, by affecting both the "supply side" and the "demand side," may shift the balance back towards NAD+.
The larger question is, why does this ratio shift with age? I sure don't know, but consider that cd38 is active in the immune response, and that many diseases of aging are now thought to result from chronic inflammation. So perhaps NADH is up because cd38 is up because there is inflammation from -- something. Many phytophenols like resveratrol and quercetin are regarded as anti-inflammatories. So what you are doing here, maybe, is suppressing the immune response to avoid autoimmune damage to healthy tissue.
If this is even remotely correct, then the even larger issue is, "What's causing the inflammation in the first place?" We like to think, oh, it's just "old age," but that's about as informative as blaming it on demons or sea monsters. My suspicion, and this goes way off topic, is that refined carbohydrate consumption, especially, added sugars, is an important root cause here, but that is a topic for some other thread.
So If I do not ingest sugar and partake of Resveratrol with other supplements I might live longer?
You make it sound so simple.
Currently, I am watching my 88 y/o Mother in Law rapidly decline in a Nursing Home.
But what I find interesting is this 103 year old blind lady that lives on Cake and Candy.
I notice she can eat and talk at the same time so I can rule out Dementia / Alzheimer.
If I knew her secret to life extension then I would be pleased.
My Point: Everyone believes sugar is evil and Resveratrol encourages longevity.