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Re: Lifemirage's regimen


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#1 scottl

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Posted 11 December 2004 - 04:33 PM


Rather then clutter up his thread I thought I would post this here. Perhaps santa will be nice and he'll comment:

1. Notice that he takes both Idebenone and pramacetam so he knows something we don't about lack of adverse effects (see prior threads). His only comment of idebenone was to take the R-ala to counter increased free radical formation from the acetyl carnitine and idebenone.

2. R-DiHydroLipoic Acid: geronova sells this. R-ALA and this are in a redox pair (from the geronova site):

R-DHLA reacts with a free radical and is oxidized back to lipoic acid which is then subsequently reduced using cellular reducing equivalents (NADH or NADPH) back to R-DHLA, thus continuing the redox cycle.

So why not just ensure an adequate aupply of NADH/NADPH?

from another site (granted this is talking about a topical prep, but still sounds like another not very stable compound):

"Although alpha lipoic acid is itself an antioxidant, it is its reduced form, dihydrolipoic acid, that is the most active as an antioxidant. Because dihydrolipoic acid is so easily oxidized (it oxidizes within minutes), it makes topical application of dihydrolipoic acid impossible. Fortunately, alpha lipoic acid is readily converted into dihydrolipoic acid"

Tune in next week for K-R-DiHydroLipoic Acid (sorry I couldn't resist).

3. ALC-Arginate--OK if he is taking this, then I take back skepticism from my prior comments

4. Under: Cellular Membrane Agents he has

PPC 900mg

So this is phosphatidyl choline and there are added benefits to this even if one is already taking...CDP-Choline and Alpha GPC?

5. Anyone know what the advantage of Vincamine over vinpocetine is?

6. Note he is taking 300 mg PS.

OK at the risk of bringing this up again--this shows my ignorance, but what is the difference in the actual molecules between bovine derived and soy derived PS?

on the PS thread Lynx wrote:

"It seems that the DHA backbone of Bovine PS is the key"

#2 scottl

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Posted 12 December 2004 - 05:52 AM

Bump

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#3 lynx

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Posted 12 December 2004 - 11:12 PM

Scott,
http://vm.cfsan.fda....s/ds-ltr36.html

In your petition, you noted two sources of phosphatidylserine: bovine brain cortex and soy lecithin (Petition at page 4). Your petition also states that the "petitioner derives phosphatidylserine from soy lecithin" (Petition at page 4). FDA evaluated whether, for purposes of the proposed health claims, BC-PS and S-PS are the same substance or are different substances because of differences in their overall composition. Chemically, the phosphatidylserine molecule consists of a glycerol-phosphate backbone, serine, and two fatty acids. Information included in your petition showed that the fatty acid composition of the bovine and soy phosphatidylserine molecules differ (PDR® for Nutritional Supplements, Attachment 2 to Petition, at 354). For example, the phosphatidylserine molecule from soy lecithin contains mainly polyunsaturated acids, while the phosphatidylserine molecule from bovine brain cortex contains mainly saturated and monounsaturated fatty acids and long-chain polyunsaturated fatty acids (e.g., docasahexaenoic acid). Additionally, the relative proportions of fatty acids from the omega-3 and omega-6 series(3) vary in the phosphatidylserine molecules from bovine and soy products. For example, the phosphatidylserine molecule from soy has 7% alpha-linolenic acid (omega-3) and 47% linoleic acid (omega-6), while the phosphatidylserine molecule derived from bovine brain cortex has 8% docasahexaenoic acid (omega-3) and 2% arachidonic acid (omega-6) (see Phosphatidylserine (Sodium Salt), Attachment 2 ). Different fatty acids differ in their metabolism, biological activity, and potency (Food and Nutrition Board, 2002). Because the phosphatidylserine molecules from bovine brain cortex and soy lecithin differ significantly in their fatty acid composition, they may not be the same substance.

In addition to the differences in the fatty acid composition of the phosphatidylserine molecules from bovine brain cortex and soy lecithin, there are also differences in the non-phosphatidylserine components of these ingredient sources. These non-phosphatidylserine components are primarily other phospholipids and free fatty acids. BC-PS is prepared by extracting and separating the phospholipid classes from brain material. The final extract will contain up to 8% of its weight as non-phosphatidylserine components (Folch, 1948). S-PS is prepared from soy lecithin that has been treated with serine and an enzyme to convert the native phospholipids in soy lecithin to phosphatidylserine (Sakai et al., 1996). The resulting phosphatidylserine content depends on the composition of starting soy lecithin product and processing conditions such as enzyme activity. For S-PS from one manufacturer, the non-phosphatidylserine components can range from 15% to 80% (Degussa, 2002). The non-phosphatidylserine components are free fatty acids and phospholipids which, as noted above, may have biological activity independent of phosphatidylserine. These other components outside the phosphatidylserine molecule of the soy sources of phosphatidylserine differ incomposition and amounts, and perhaps also in biological activity, from the non-phosphatidylserine components in BC-PS. For products of high purity (i.e., relatively low amounts of non-phosphatidylserine components), uncertainties as to any biological effects of the non-phosphatidylserine components would be minimized.

For the reasons summarized above, FDA considers that bovine brain cortex- and soy lecithin-sources of phosphatidylserine may be different substances and may, therefore, have different biological activities. Thus, there is considerable uncertainty in generalizing results from studies done with BC-PS containing products as the test substance to products containing S-PS, and vice versa.



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#4 scottl

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Posted 12 December 2004 - 11:56 PM

Lynx--thanks.




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