LONGECITY

Resveratrol was incorporated into a CM based gel and they did a stability study which looks good. I don't have acne but might try their gel formula on my regularly aging skin.....



Am J Clin Dermatol. 2011 Apr 1;12(2):133-41. doi: 10.2165/11530630-000000000-00000.
Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study.
Fabbrocini G, Staibano S, De Rosa G, Battimiello V, Fardella N, Ilardi G, La Rotonda MI, Longobardi A, Mazzella M, Siano M, Pastore F, De Vita V, Vecchione ML, Ayala F.
Department of Systematic Pathology, Division of Clinical Dermatology, University of Naples Federico II, via S. Pansini 5, Naples, Italy. gafabbro@unina.it
Abstract

BACKGROUND: Acne vulgaris is a complex, chronic, and common skin disorder of pilosebaceous units. The major pathogenic factors involved are ductal hyperkeratinization, obstruction of sebaceous follicles resulting from abnormal keratinization of the infundibular epithelium, stimulation of sebaceous gland secretion by androgens, and microbial colonization of pilosebaceous units by Propionibacterium acnes, which promotes perifollicular inflammation.

AIM: The aim of the study was to investigate the therapeutic effects of resveratrol, a natural phytoalexin produced by some spermatophytes, such as grapes and other plants, on acneic skin.

METHODS: Resveratrol was incorporated in a carboxymethylcellulose-based gel. The chemical stability of resveratrol after storage at 4°C for 30 days was investigated by high-performance liquid chromatography (HPLC). The resveratrol-containing hydrogel was administered to 20 patients affected by acne vulgaris enrolled in this single-blind study. The resveratrol-containing formulation was applied daily as a solo treatment on the right side of the face for 60 days, while the hydrogel vehicle was applied to the left side of the face as a control. To objectively evaluate the results, a digital photographic database was used to collect images. The number and type of lesions were recorded for each patient, to compare the Global Acne Grading System (GAGS) score before treatment with that obtained at the end of the study. Moreover, with the innovative technique of follicular biopsy, areas of acneic skin were prepared for histopathology. The average area occupied by microcomedones at baseline was compared with that at the end of treatment.

RESULTS: HPLC analysis demonstrated that resveratrol, upon incorporation into the gel, did not convert to its cis-isomer when stored at 4°C for 30 days. All patients were satisfied with the active treatment and none experienced adverse effects. Clinical evaluation showed a 53.75% mean reduction in the GAGS score on the resveratrol-treated sides of the face compared with 6.10% on the vehicle-treated sides of the face. These data were supported by histologic analysis, which showed a 66.7% mean reduction in the average area of microcomedones on the resveratrol-treated sides of the face. The comparison with the vehicle-treated side of the face (9.7% reduction) showed a clinically relevant and statistically significant decrease of lesions in areas treated with resveratrol-containing hydrogel.

CONCLUSION: This pilot study showed positive results for resveratrol gel in acne, and should be considered a valid starting point for further testing of the effectiveness of this molecule in different concentrations and formulations and in a larger group of patients.

PMID: 21348544 [PubMed - in process]

From the Conclusions: " At the end of the study, all patients had a visible clinical improvement on the resveratrol-treated side of the face, including
a remarkable decrease in inflammation and pustularlesions. This clinical improvement was well documented by
digital photographs."

Take acutane, it works.

Accutane does not work with acne rosacae, but from experience I can say resveratrol cream does. Not surprising, as res is anti bacterial and a fungicide.

You can make your own cream bu adding half a gram of 98% res to 2 ounces of your favorite face cream; it will be stable at the typical skin cream pH. also, Kingherbs (former site sponsor) sells one.

WRT accutane, it can have serious side effects.

Accutane does not work with acne rosacae, but from experience I can say resveratrol cream does. Not surprising, as res is anti bacterial and a fungicide.

You can make your own cream bu adding half a gram of 98% res to 2 ounces of your favorite face cream; it will be stable at the typical skin cream pH. also, Kingherbs (former site sponsor) sells one.

WRT accutane, it can have serious side effects.

Accutane works with acne vulgaris and it did wonders for my skin. After treatment I rarely got pimples afterwards. The only side effects I had were those that appeared during treatment such as feeling a bit dehydrated and dry skin.

Take acutane, it works.

Works pretty well for personal injury lawyers, too.

Accutane & Crohn’s Disease - Side Effect Information

Accutane is a medication intended for the treatment of severe acne. It was first introduced in 1982 and has been used by more than 16 million patients worldwide. Citing growing competition from generics and a string of Accutane lawsuits, the makers of the drug pulled it from the U.S. market in 2009. However the medication continues to remain in use in other countries.

Throughout its history, Accutane has been linked with several severe side effects including birth defects and suicide. It has also been linked to inflammatory bowel disease and Crohn’s disease, a chronic illness that affects the digestive tract. Crohn’s disease is often characterized by the following symptoms:

* Abdominal discomfort often located in the lower right quadrant
* Bloody stools
* Loss of appetite
* Severe diarrhea
* Ulcers
* Weight loss

Sorry for taking things even further off topic.

Take acutane, it works.

Works pretty well for personal injury lawyers, too.

Accutane & Crohn’s Disease - Side Effect Information

Accutane is a medication intended for the treatment of severe acne. It was first introduced in 1982 and has been used by more than 16 million patients worldwide. Citing growing competition from generics and a string of Accutane lawsuits, the makers of the drug pulled it from the U.S. market in 2009. However the medication continues to remain in use in other countries.

Throughout its history, Accutane has been linked with several severe side effects including birth defects and suicide. It has also been linked to inflammatory bowel disease and Crohn’s disease, a chronic illness that affects the digestive tract. Crohn’s disease is often characterized by the following symptoms:

* Abdominal discomfort often located in the lower right quadrant
* Bloody stools
* Loss of appetite
* Severe diarrhea
* Ulcers
* Weight loss

Sorry for taking things even further off topic.

The possible side effects are not severe enough in my opinion to outway the benefits of curing acne.

The possible side effects are not severe enough in my opinion to outway the benefits of curing acne.

Obviously, your opinion is your own. It doesn't seem to be widely held by the drug company that pulled it from the market, injured patients, and their lawyers.