You recently posted a link to a study which raised questions about niacinamide as a form of B3. Is that the only study supporting this?
No, there are plenty; it's well-known that niacinamide inhibits sirtuins. Try this PubMed search string:
(sirtuins OR sir2 OR sirt1) AND (niacinamide[tw] OR nicotinamide[tw])
See especially this report:
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in
Saccharomyces cerevisiae. Nature. 2003 May 8;423(6936):181-5.
http://www.ncbi.nlm....t_uids=12736687The only real question is how the biochemistry works out in terms of cellular levels of nicotinamide after oral administration, and the relevance to mammals of the sirtuins' role in lifespan. These are certainly not small questions, but as there is to my knowledge no good reason to take nicotinamide instead, it makes in my opinion no sense not to heed this caution.
Do you really believe we should all be taking all our B3 as niacin?
Including inositol hexanicotinate: yes.
And what of this comment from sci.life-extension (this was a post discussing niacin):
"I am not commenting on Niacin, since there are many long term questions about what it does to the mitochondria and the Kreb cycle."
Do you know what they are they referring to?
Nope! Have you asked him/her to clarify his/her concerns, and provide citations? I'd be happy to evaluate that (though, of course, if there
are legitimate reasons to be suspicious of
both B3 vitamers, things suddenly become rather paralyzing ...).
And how certain is that?
Well, whatever this person was thinking, clearly s/he didn't think it was certain at all: saying that "there are many long term questions about" the putative effect is to say that it's very much in the air. Again, I can't personally weigh in on this as I've no idea what s/he's on about.
To your health!
AOR
