13 replies to this topic

[j03]

Are there any risk to taking n-acetylcysteine @ 1800 mg - 3000 mg long term?

[caruga]

Funny you should ask as I've just been reading about this today. Seems there is a risk of kidney stones with NAC administration. It helps to accompany it with a dose of vitamin C. I'm curious what benefits you're receiving from NAC right now? Do you take it with plenty of fluid afterward, or just take the NAC?

[Dorian Grey]

A study from 2007 created a lot of concern over NAC... The doses were high, but the result was scary. More may not be better when it comes to NAC...

http://en.wikipedia..../Acetylcysteine

Researchers at the University of Virginia reported in 2007 study using very large doses in a mouse model that acetylcysteine, which is found in many bodybuilding supplements, could potentially cause damage to the heart and lungs.[23] They found that acetylcysteine was metabolized to S-nitroso-N-acetylcysteine (SNOAC), which increased blood pressure in the lungs and right ventricle of the heart (pulmonary artery hypertension) in mice treated with acetylcysteine. The effect was similar to that observed following a 3-week exposure to an oxygen-deprived environment (chronic hypoxia). The authors also found that SNOAC induced a hypoxia-like response in the expression of several important genes both in vitro and in vivo.
The implications of these findings for long-term treatment with acetylcysteine have not yet been investigated. The dose used by Palmer and colleagues was dramatically higher than that used in humans;[23] nonetheless, positive effects on age-diminished control of respiration (the hypoxic ventilatory response) have been observed previously in human subjects at more moderate doses.[24]

[pycnogenol]

All I know is when I take NAC my blood glucose spikes up.

[Ark]

Nac is super powerful stuff, it's great but I really think it should be cycled.

Good for OCD and lung health.

[Wondherb]

Funny you should ask as I've just been reading about this today. Seems there is a risk of kidney stones with NAC administration. It helps to accompany it with a dose of vitamin C. I'm curious what benefits you're receiving from NAC right now? Do you take it with plenty of fluid afterward, or just take the NAC?

I get good clean motivating energy from 2000 mg Source Naturals NAC every morning.

[Wondherb]

All I know is when I take NAC my blood glucose spikes up.

Did you try taking it with berberine to control your glucose?

[pycnogenol]

All I know is when I take NAC my blood glucose spikes up.

Did you try taking it with berberine to control your glucose?

Been there, done that with the same exact result. Come to find out that NAC is capable of inactivating insulin by reducing some disulfide bonds, including one or more of the three disulfide bonds that determine insulin's tertiary structures.

Edited by pycnogenol, 22 May 2011 - 01:50 PM.

[chrono]

I'd take a look at this thread: NAC poll part 2. Some possibilities raised that become more possible with chronic high dosages.

[Julia36]

Affected me badly @ 800mg a day after 4 days.

[Ukko]

All I know is when I take NAC my blood glucose spikes up.

Did you try taking it with berberine to control your glucose?

Been there, done that with the same exact result. Come to find out that NAC is capable of inactivating insulin by reducing some disulfide bonds, including one or more of the three disulfide bonds that determine insulin's tertiary structures.

Hey, that could be really useful. Isn't the problem with insulin insensitivity that the body has overproduce insulin cause the cells are not receptive to it? Then some of it remains around leading to a hypoglycemic episode. And then the poor bastard eats more bad stuff. And so the cycle goes. So, timing NAC right could be like an insulin mop?

[Gal220]

I would cycle it or use as necessary with flu/covid

 

Some other threads

 

Whats so wrong about NAC

 

NAC : a warning shot

[CharlieG]

I did this for a while, where I was taking higher amounts over the longterm. I don't recommend it. It is excellent to use over the short-term for certain situations. If you are around people who are sick and trying to prevent that illness (excluding Covid) it can help. It raises level of glutathione, offering some extra protection. There are studies showing it as being a very helpful supplement to take before certain procedures that would cause damage (ie: dye injections with CT scans and the scans themselves can cause damage) and it helps to prevent some of that damage. Another study showed it greatly lessened the severity of multiple flu strains in the most vulnerable, elderly. If I get COVID, for example, I'll be taking a good deal of it - not too much, in addition to other supplements. My only concern about longterm high supplementation is that if you were to develop a cancercous tumor, it would help it to grow, from what I have read. I don't have time to link to the studies right now, sorry. But, it is something to keep in mind or look into anyway.