34 replies to this topic

[olaf.larsson]

Some super antioxidant has been developed that is 100 times stronger than vit. E does anyone know more about this?

[Chip]

Astaxanthin, considered to also be around 10 times more powerful than vitamin A. I take 400 mg a day.

[lynx]

Well, I think nTBHA fits that too.

[magr]

Astaxanthin, considered to also be around 10 times more powerful than vitamin A. I take 400 mg a day.

Is this a 2% compound like BAC sells?

[Chip]

Oops, I was mistaken. My Nutraceutical brand of capsules are stated on the label as providing 4 mg of Astaxanthin each, not 400 mg. Thanks for catching that magr. I do a quick look around on the web and see the BAC product as taken by many provides 2 mg per day. I get more through the brewers yeast I consume most every day, about a tablespoons worth. I see on this site they mention a study where people have consumed around 14 mg per day for weeks with no noticed ill repercussions: http://www.aquasearch.com/astax-3.htm

Here is the exact brand I am taking: http://www.vitacost....611&bt=products . I bought about a dozen bottles a few months ago and expect to not have to buy any more for a while. What do you think? I thought the price was right when I bought them but perhaps there are mitigating factors such as bioavailability or new products of which I am unaware. Any further disclosure of my ignorance in such matters would be appreciated. [lol]

Chip

[Chip]

Hmmm, NtBHA looks quite interesting. Any body here taking it and where do you get it and is there a decent web site covering it somewhere? I'll do more searching of my own later but got to do other things right now.

[magr]

www.geronova.com

[lynx]

nTBHA is beyond interesting, it is in fact quite a miracle. I have some good papers if you want to read up on it.

[Chip]

Did some searching and reading. Still have not come across what amount was given to the mice and rats in the studies to observe the anti-aging and radioprotective levels. I also would like to know more about the sources I see for it so far, $150 for five grams seems outrageous. Is there a dietary or herbal source? The lack of in vivo human studies gives me motivation to hold out for more information. What is its relation to R-lipoic acid? What are the sources of that? Lots of questions. Will have to study and research this for awhile no doubt.

lynx, how might I get those papers from you. Are they in electronic form? PM me maybe. TIA

Chip

[lynx]

The relation to R-lipoic acid can only be indirectly ascertained, in that Ames used PBN/ALCAR combos and got the same results as R-ALA/ALCAR. nTBHA is one possible metabolite of PBN. nTBHA has shown similar mitochondrial metabolism improvement to PBN and R-ALA.

I am looking for the papers.

Morelife.org has some really good arguments for the superiority of nTBHA over PBN.

[olaf.larsson]

How about not using cryptic combinations of letters and instead write the full names so everyone could understand what you are talking about?

[olaf.larsson]

Yes N-t-Butyl hydroxylamine iseems to be a miracle. It seems to be a quite simle chemical it shouldnt be very hard to produce.

[lynx]

How about not using cryptic combinations of letters and instead write the full names so everyone could understand what you are talking about?

Because people who are familiar with free radical research use the abbreviations out of convenience.

[syr_]

The relation to R-lipoic acid can only be indirectly ascertained, in that Ames used PBN/ALCAR combos and got the same results as R-ALA/ALCAR. nTBHA is one possible metabolite of PBN. nTBHA has shown similar mitochondrial metabolism improvement to PBN and R-ALA.

I am looking for the papers.

Morelife.org has some really good arguments for the superiority of nTBHA over PBN.

I know that is an old thread but i had it bookmarked

Can someone post some papers/references links to nTBHA?

[simple]

If I am looking for a strong antioxidant, should I use its ORAC value to determine the strongest ?

[ajnast4r]

If I am looking for a strong antioxidant, should I use its ORAC value to determine the strongest ?

the problem using only the orac scale, is that antioxidents become oxidized! lol. google about 'free radical cascades'


look for multiple antioxidents that work in complex... E complex + C + r-ala, NAC + C, etc etc

or antioxidents that dont become potent free radicals after oxidation like CoQ10(although coq10 is super expensive, there are others i just cant remember).


herbal antioxident complexs that have other health benefits are good... ie: full spectrum green tea or berry extracts.

[simple]

Wasn't Idebenone the "alter ego" of co q10 on that regards, How 'bout chocolate, according to ORAC values, it is one of the highest?

[simple]

Wasn't Idebenone the "alter ego" of co q10 on that regards, How 'bout chocolate, according to ORAC values, it is one of the highest?

[simple]

Wasn't Idebenone the "alter ego" of co q10 on that regards, How 'bout chocolate, according to ORAC values, it is one of the highest?

[simple]

Sorry about the three postings computer mess up!

[syr_]

This seems the good thread to ask if someone knows about GliSODin®?

http://www.nowfoods....l&item_id=43852

refs:

Y. Kong, et al., Korea Cancer Center Hospital, “Influence of an orally effective superoxide dismutase (GLISODin)® on strenuous exercise-induced changes of blood antioxidant enzymes and plasma lactate” AACC Poster, Presented July 2004

Free Radic Res. 2004 Sep;38(9):927-32. Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Muth CM, Glenz Y, Klaus M, Radermacher P, Speit G, Leverve X. Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum Ulm, D-89073 Ulm, Germany. PMID: 15621710 [PubMed - in process]

[biknut]

"In another human study, healthy volunteers supplemented their diets with 1,500 mcg. of GliSODin® for four weeks. Prior to GliSODin® use, the volunteers participated in strenuous exercise and baseline measurements of serum total antioxidant status, plasma lactate accumulation and several other markers were taken. After supplementation, the exercise was repeated and the oxidative stress markers were measured once again. GliSODin® supplementation resulted in a significant change in oxidative status and a significant decrease in exercise-induced lactate (lactic acid) release, suggesting that damage caused by oxidative stress was significantly inhibited. Lactic acid produced by exercise is a cause of muscle pain and fatigue during exercise."

Ok, who said so? How much was the oxidative stress before they started and how much was it after the study? Glisodin is never very clear about this. Why do they not do a peer review human study proving it reduces oxidative stress?

For that mattter, why doesn't any manufacture of anti-oxidants do a peer review human study proving their anti-oxidants reduce oxidative stress?

[DukeNukem]

FYI, LEF endorses GliSODin.

[biknut]

I'm not saying Glisodin doesn't work. I'm just saying there's no way to tell how well it reduces oxidative stress in humans. Same with with any other anti-oxidant you care to name.

LEF also endorses GH3.

[biknut]

Now that I think about it LEF rates GH3 number 6 of the top 10 life extension drugs.
Glisodin didn't make the list.

http://www.esculape....nsiondrugs.html

[FunkOdyssey]

That list is ten years old, I'm sure that would look alot different now. It seems like they have quit discussing anti-aging drugs in recent years.

[syr_]

*sigh* my post is gone due to the time limit :(

What I said was:

1) There are no anti-oxidants in that list, because a stack of different ones is needed to achieve good results. Look at the "protandim" thread.

2) There is not enough literature for LEF to recommend it in the top list.

3) Considering that I already take a good stack of anti-oxidant, adding Glisosin seems a good idea. I'm not the only one here that takes it

[biknut]

That list is ten years old, I'm sure that would look alot different now. It seems like they have quit discussing anti-aging drugs in recent years.

Yea, 10 years is kind of old. The main thing that suprised me about that list was that GH3 was even on it.

[biknut]

It's hard to tell about Glisodin. All the information I see about it seems to beat around the bush or is deceptive. What makes me question it the most is this, Glisodin likes to point out how much more SOD and CAT and GPX is found in the blood after taking it. That sounds good, But how much does that reduce oxidative stress? They are always kind vague about this.

I've seen studies where people taking vitamin C and E had elevated C and E in their blood, but no reduction in oxidative stress.

This might or might not be the case with oral plant SOD. Why doesn't Glisodin do a study where they just do a before and after test of oxidative stress to answer this question?

[syr_]

This might or might not be the case with oral plant SOD. Why doesn't Glisodin do a study where they just do a before and after test of oxidative stress to answer this question?

Money I guess. Doing clinical studies is VERY expensive and supplement companies rarely can afford them. I dont know who made Glisodin, but I dont think its a pharma.