5 replies to this topic

[ironmind]

Piracetam: 800-1600mg/day maybe do that loading idea ppl say to do which is 2400mg 2x/day for one month then 1200mg thereafter.
Phenibut: dont know yet, any recommendations?
Picamilon: 200-300mg/day
DMAE: 1,080mg-1,620mg/day

My goal is mainly to enhance learning abilities and memory which I think equals intelligence. Also would like to see it's benefits for socializing, I'm already a great socializer, let's see if it adds some spice to what I already have.

[LifeMirage]

Piracetam: 800-1600mg/day maybe do that loading idea ppl say to do which is 2400mg 2x/day for one month then 1200mg thereafter.
Phenibut: dont know yet, any recommendations?
Picamilon: 200-300mg/day
DMAE: 1,080mg-1,620mg/day

My goal is mainly to enhance learning abilities and memory which I think equals intelligence. Also would like to see it's benefits for socializing, I'm already a great socializer, let's see if it adds some spice to what I already have.


I would skip the picamilon in my experience it can block phenibut's effects, Phenibut for loading 1.6-3.2 Grams 200-600 mg afterwards, Piracetam I would do 4.8-9.6 Grams for the first 2-3 days then 1.6-2.4 afterwards, DMAE I would recommend taking Centrophenoxine 250-500 mg instead as a better form.

[magr]

I would absolutely NOT take Phenibut on a daily basis! It will lead to bad withdrawal when you stop taking it.

Where have you gotten this info on Phenibut from LifeMirage?

I would only take Phenibut on stressful occasions. A couple of times a month. Tolerance builds quickly.
I would not call it a nootropic per se, more of a stress-reliever.

[dopamine]

Phenibut might be alright on a daily basis provided your dose is very low (less than 1 gram). Still, there are many reports that withdrawal can occur when using it chronically, so the same could apply for using acute doses over time.

I would ditch the DMAE, as it's studied effects are contradictory. For a choline source I would recommend Alpha GPC if it's within your budget, or CDP-Choline.

Aniracetam, in my experience, has proved to have a much more of a social effect, i.e. increasing extroversion generally. Piracetam seems to have a more cold effect, not reaching too much into the areas of emotional response to social stimuli.

Eur J Pharmacol. 2001 May 18;420(1):33-43.
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.

Nakamura K, Kurasawa M.

CNS Supporting Laboratory, Nippon Roche Research Center, 200 Kajiwara, Kamakura, 247-8530, Kanagawa, Japan. kazuo.nakmura@roche.com

The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety. This study, therefore, aimed to characterize the anxiolytic effects of aniracetam in different anxiety models using mice and to examine the mode of action. In a social interaction test in which all classes (serotonergic, cholinergic and dopaminergic) of compounds were effective, aniracetam (10-100 mg/kg) increased total social interaction scores (time and frequency), and the increase in the total social interaction time mainly reflected an increase in trunk sniffing and following. The anxiolytic effects were completely blocked by haloperidol and nearly completely by mecamylamine or ketanserin, suggesting an involvement of nicotinic acetylcholine, 5-HT2A and dopamine D2 receptors in the anxiolytic mechanism. Aniracetam also showed anti-anxiety effects in two other anxiety models (elevated plus-maze and conditioned fear stress tests), whereas diazepam as a positive control was anxiolytic only in the elevated plus-maze and social interaction tests. The anxiolytic effects of aniracetam in each model were mimicked by different metabolites (i.e., p-anisic acid in the elevated plus-maze test) or specific combinations of metabolites. These results indicate that aniracetam possesses a wide range of anxiolytic properties, which may be mediated by an interaction between cholinergic, dopaminergic and serotonergic systems. Thus, our findings suggest the potential usefulness of aniracetam against various types of anxiety-related disorders and social failure/impairments.

[magr]

In Russia they prescribe Phenibut for anxiety. It comes in 250mg caps.
The dosages usually prescribed are 1/2 - 2 caps daily (125-500mg) as far as I understand.
I once took 600mg Phenibut for about 14 days in a row and I got withdrawal from it.
People are different ofcourse.

[LifeMirage]

I would absolutely NOT take Phenibut on a daily basis! It will lead to bad withdrawal when you stop taking it.

Where have you gotten this info on Phenibut from LifeMirage?

I would only take Phenibut on stressful occasions. A couple of times a month. Tolerance builds quickly.
I would not call it a nootropic per se, more of a stress-reliever.

1. There are no studies on Medline I've seen showing or suggusting tolerance or withdraw.
2. I've given 200-400 mg to patients on a regular basis with increases as needed without problems, some people in my experience have seen a drop in GABA 1-2 after (causing what can be called withdraw) after taking 2-4 Grams at once. Taking theanine can correct orm prevent this in most cases.
3. Phenibut although having neuroprotective effects and may be helping for learning may not fit what most people consider a nootropic.