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Researchers can reverse aging process for human adult stem cells

stem cells

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#31 revenant

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Posted 21 January 2012 - 03:57 AM

I wonder if simply taking ALA could be of some benefit in preventing Alu sequence copies. It is apparently an effective RT inhibitor.

http://www.ncbi.nlm..../pubmed/1724477

"An over 90% reduction of reverse transcriptase activity could be achieved with 70 micrograms alpha-lipoic acid/ml,"


If this is the case, why is ALA not an effective HIV therapy?


Perhaps it is. I would bet ALA can help HIV patients tremendously. I will look for some full text studies.

Q: can big pharma profit off of ALA?
A: No

#32 niner

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Posted 21 January 2012 - 07:10 PM

I wonder if simply taking ALA could be of some benefit in preventing Alu sequence copies. It is apparently an effective RT inhibitor.

http://www.ncbi.nlm..../pubmed/1724477

"An over 90% reduction of reverse transcriptase activity could be achieved with 70 micrograms alpha-lipoic acid/ml,"


If this is the case, why is ALA not an effective HIV therapy?


Perhaps it is. I would bet ALA can help HIV patients tremendously. I will look for some full text studies.

Q: can big pharma profit off of ALA?
A: No


Before engaging in Big Pharma profit paranoia, if might be worth considering that 70ug/ml is a very large dose of ALA; Maybe 5 grams for an adult human? I don't know about ALA tox, but that's a big dose. ALA has a very short half life, so you might need to dose every couple hours. ALA has off-target activities, so there are likely to be lots of side effects, particularly at monster doses. Basically, it is a pretty crappy candidate for HIV therapy.
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#33 revenant

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Posted 23 January 2012 - 07:58 PM

I wonder if simply taking ALA could be of some benefit in preventing Alu sequence copies. It is apparently an effective RT inhibitor.

http://www.ncbi.nlm..../pubmed/1724477

"An over 90% reduction of reverse transcriptase activity could be achieved with 70 micrograms alpha-lipoic acid/ml,"


If this is the case, why is ALA not an effective HIV therapy?


Perhaps it is. I would bet ALA can help HIV patients tremendously. I will look for some full text studies.

Q: can big pharma profit off of ALA?
A: No


Before engaging in Big Pharma profit paranoia, if might be worth considering that 70ug/ml is a very large dose of ALA; Maybe 5 grams for an adult human? I don't know about ALA tox, but that's a big dose. ALA has a very short half life, so you might need to dose every couple hours. ALA has off-target activities, so there are likely to be lots of side effects, particularly at monster doses. Basically, it is a pretty crappy candidate for HIV therapy.


I do tend to distrust Big Pharma... corporations in general. Thanks for putting this into perspective.

A time release form of ALA may possibly be a safe and effective RT inhibitor.

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#34 okok

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Posted 23 January 2012 - 08:15 PM

Don't know if this is of any practical interest, but

In vitro anti-HIV-1 activity of chondroitin polysulphate.

Jurkiewicz E, Panse P, Jentsch KD, Hartmann H, Hunsmann G.

Source

Deutsches Primatenzentrum, Göttingen, FRG.

Abstract

Three chondroitin sulphates and five chondroitin polysulphates, with molecular weights ranging from 3000 to 30,000 daltons, were evaluated applying the MT-4 cell-culture assay for inhibition of HIV-1 replication. These results were compared with those obtained with compounds of known in vitro antiretroviral activity, namely, dermatan sulphate, heparin, dextran sulphate, pentosan polysulphate, zidovudine (AZT) and suramin. Chondroitin polysulphate with a molecular weight (MW) of 9000 daltons (CPS 9000) was the most effective polyanionic compound studied. In contrast with zidovudine, this CPS 9000 was not toxic for MT-4 cells up to a concentration of 500 micrograms/ml. Moreover, CPS 9000 is highly specific for inhibition of HIV-1 reverse transcriptase.


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#35 revenant

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Posted 25 January 2012 - 03:29 AM

Don't know if this is of any practical interest, but
In vitro anti-HIV-1 activity of chondroitin polysulphate.


Very interesting. I'm not good at coversions. I wonder how much would be needed to get an effective dose?

#36 revenant

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Posted 25 January 2012 - 03:33 AM

Chemicals in Ganoderma lucidum (reishi mushroom) inhibit protease and reverse transcriptase.

http://www.canited.com/reishi97d-6.htm

"This paper describes the isolation of thirteen compounds, and their inhibitory effects against HIV-1 and its enzyme PR"

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#37 revenant

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Posted 26 January 2012 - 05:59 AM

Resveratrol derivatives as RT inhibitors.

http://finechem.dlut...d Synthesis.pdf

#38 jans

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Posted 25 March 2014 - 06:09 AM

Peter Nygard is featured in a YouTube video claiming stem cell technology being developed in the Bahamas is making him look and feel younger. http://www.cbc.ca/ne...hamas-1.2555831 Hei is probably just full of it http://corporate.nyg...rger-than-life/ marketing his clothebrand.
“From the woman’s egg, we took out her DNA, put my old 70-year-old DNA in its place [and] grew it in vitro,” he says in the video. “I may be the only person in the world who has my own embryonic stem cells growing in a petri dish.”
Then, Nygard makes his boldest claim.
“This is huge. This is a game changer. This could eliminate all disease. This perhaps is immortality,” he says.

#39 Vardarac

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Posted 06 April 2014 - 03:35 AM

At risk of necromancy, has this research been advanced any? Have these results been duplicated, or mechanisms similar to ERV transcript silencing causing young-like phenotypes observed in organisms with negligible senescence?

Edited by Vardarac, 06 April 2014 - 03:37 AM.


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#40 addx

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Posted 08 April 2014 - 04:40 PM

I've posted something about this that might explain it.

 

Vardarac you know the topic.

 

http://www.longecity...volution/page-3

 

The post with a lot of links explains opioids effects on stem cells. And also shows that my guess was right. 

 

I do think I have a theory on everything including ageing. But hard to get some validation :)

 

 

Vardarac I know you asked me what's the purpose of my theory. Do you see the purpose now? My theory predicts these kinds of things with ease. This could have been researched long ago, if they knew the fundamentals they'd know where too look first. And they wouldn't be so confused about results.

 

At this points it seems like they are staring to hard at a tree and can't(or won't) see the forest.

 


Edited by addx, 08 April 2014 - 04:50 PM.






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