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Vitamin K2 amount

vitamin k2 vimmortal 2.0 menaquinone-7

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#1 Mind

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Posted 07 February 2012 - 10:03 PM


The amount of vitamin K2 (from menaquinone-7) in Vimmortal 1.0 was 45 mcg or 56% DV.

Is there any recent research or rationale for changing the amount of K2 in Vimmortal 2.0?

#2 nameless

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Posted 08 February 2012 - 03:40 AM

I'd recommend either increasing it or dropping it entirely.

My rationale is this:

Most people take a partial dose of the multi. In fact, almost everyone should. So if a person takes 1/3rd to 1/2nd of the current dose, the amount of K2 becomes lower than optimal, even lower than the amounts found protective in the Rotterdam study. So then a person has to take a separate K2 supplement to make up for the small dose found in Vimmortal. And if that is the case, why bother to include it at all?

I'd increase MK-7, include MK-4, as well, and if MK 8 or 9 could somehow be added, do that too. If none of those can be done, I'd just drop it entirely, as then it becomes similar to those 'trace amounts' found in some multis, just put there to make the label look good.

#3 maxwatt

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Posted 08 February 2012 - 01:46 PM

This paper might be a reason for including MK-4 in addition to, or instead of, MK-7: In addition to Vimmortal, I take extra D2 in the form of MK-7 or MK-4. NK-7 seems to prevent or eliminate calcium deposits in the arteries, MK-4 keeps calcium in the bones. MK8 and 9 I'm not familiar with their benefits, but remember hearing they can be toxic with higher doses. ??? Something to research.

J Mol Endocrinol. 2007 Oct;39(4):239-47.


Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells.

Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S.



Source

Division of Gene Regulation and Signal Transduction,, Research Center for Genomic Medicine, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan.



Abstract

Vitamin K is known as a critical nutrient required for bone homeostasis and blood coagulation, and it is clinically used as a therapeutic agent for osteoporosis in Japan. Besides its enzymatic action as a cofactor of vitamin K-dependent gamma-glutamyl carboxylase (GGCX), we have previously shown that vitamin K(2) is a transcriptional regulator of bone marker genes and extracellular matrix-related genes, by activating the steroid and xenobiotic receptor (SXR). To explore a novel action of vitamin K in osteoblastic cells, we identified genes up-regulated by a vitamin K(2) isoform menaquinone-4 (MK-4) using oligonucleotide microarray analysis. Among these up-regulated genes by MK-4, growth differentiation factor 15 (GDF15) and stanniocalcin 2 (STC2) were identified as novel MK-4 target genes independent of GGCX and SXR pathways in human and mouse osteoblastic cells. The induction of GDF15 and STC2 is likely specific to MK-4, as it was not exerted by another vitamin K(2) isoform MK-7, vitamin K(1), or the MK-4 side chain structure geranylgeraniol. Investigation of the involved signaling pathways revealed that MK-4 enhanced the phosphorylation of protein kinase A (PKA), and the MK-4-dependent induction of both GDF15 and STC2 genes was reduced by the treatment with a PKA inhibitor H89 or siRNA against PKA. These results suggest that vitamin K(2) modulates its target gene expression in osteoblastic cells through the PKA-dependent mechanism, which may be distinct from the previously known vitamin K signaling pathways.



PMID: 17909264 [PubMed - indexed for MEDLINE]



FULL PAPER

#4 Logan

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Posted 08 February 2012 - 09:04 PM

Eat hard stinky cheese, fermented soy, eggs from pasture fed chickens, grassfed beef, and whole milk yogurt from grassfed cows-preferrably unhomogenized and flash pasterized. It should be pretty easy to cover K2 intake, unless you are calorie restricted.

#5 Mind

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Posted 08 February 2012 - 10:18 PM

We could all go CRON. No supplements needed, right? The point of the project is that people who are not Cronies like having a multi-vitamin/multi-nutrient supplement handy. The term most often used is "covering the bases". There is a market for multis and members here wanted their own. Keep that in mind. The first version of Vimmortal sold 1,500 units. I would be happy if we sold that much of Vimmortal 2.0. More would be better. If it finds a wider audience among the general public (with poor diets), then we would be doing a great service for healthy lives. Read here if you want to comment about the rationale for including a broad spectrum of lower dosage nutrients. If everyone has changed their rationale then we would need to drop a few items perhaps.

#6 Mind

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Posted 29 February 2012 - 10:38 PM

Also read here before the open discussion/voting is closed.





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