The eventual understanding of the molecular basis of progeroid syndromes such as Werner syndrome (WS) and Hutchinson–Gilford progeria syndrome (HGPS) is a major goal of modern gerontology. Not only is this important in its own right to eventually ease the suffering produced by these disorders, but also, by understanding the molecular basis of accelerated senescence, it is hoped that important clues to normal aging will be obtained. We have witnessed dramatic advances in this area over the last few years, with the identification of genes involved in several progeroid syndromes. The field has now entered a new phase, namely the elucidation of the biochemical roles of the proteins involved in these disorders and characterization of molecular defects associated with the primary mutations. One important tool in this new research effort in the study of progerias is the use of DNA microarrays.
LongeCityAdvocacy & Research for Unlimited Lifespans
