17 replies to this topic

[live4eva]

Hi, just turned 30, and wow it's surprising how all a sudden, your age can start catching up with you. I take curcumin, cod liver capsules, lecithin and selenium everyday, but would like to know what other supplements I can take to slow down DNA damage. I looking for stuff to take that doesn't break the bank and easy to get hold of. I already am on a low calorie diet (never really ate much daily since I was a kid).


There are just too many scientific articles/studies to read ( have tried) and would appreciate the knowledge from older members can knows what works and doesn't have side effects, even tho one study may claim it works, another see's side effects, basically the safest options. In advance, thanks for your replies.

Edited by live4eva, 15 July 2012 - 07:54 PM.

[Dorian Grey]

When it comes to longevity in males, sometimes it's not what you take, but what you don't take...

Governments have ordered much of the food supply to be fortified with iron to help combat anemia in menstruating females. Unfortunately, iron has a nasty habit of building up in men and wreaking havoc with their health.

Look here: http://www.lewrockwe...di/sardi65.html

And here: http://www.longevine...of-aging-part1/

Coffee with breakfast and ice tea (without lemon) with lunch can block iron absorption. Take vitamin-C away from meals on an empty stomach as it promotes iron absorption from food.

Monitor your "ferritin" levels every time you have blood work done through your doctor, and donate blood if ferritin starts creeping up towards triple digits. The upper limit of the normal range for ferritin is set outrageously high @300 for men, but you'll enjoy longer life and better health if you keep ferritin well under 100, with 40 to 60 as the optimal range.

Women live nearly a decade longer than men on average, and it's not the estrogen that helps as hormone replacement does not extend their longevity. The reason women live longer is they avoid iron overload throughout much of their lives through menstruation and child birth.

Best of Luck to you.

[live4eva]

Thanks for you're response. I always keep away from iron as I know it can cause oxidation e.t.c. Anyone know supplements I can take to look younger for longer?

[Dorian Grey]

Biotin was called "Vitamin-H" by the German who did early research on it as he found it was good for "Haar und Haut", the German words for hair and skin.

[tham]

First choice, MAK-4, supplemented with MAK-5.


http://www.biomedcen...m/1472-6882/5/8

http://www.biomedcen.../1472-6882/7/19

http://www.ncbi.nlm....om=amrit kalash

http://www.ncbi.nlm....om=amrit kalash

http://www.ncbi.nlm....om=amrit kalash

http://www.ncbi.nlm....2018521/related


http://www.mapi.com/...ctar_paste.html

http://www.maharishi...t_Kalash_1.html

http://www.ayurveda....gisch 903.html


The brochure which they sent me years ago was titled "Beyond Antioxidants".

Note that MAK4 paste doesn't taste very pleasant (to me, and made my
father cringe too).

Nor is it a choice if you are on a tight budget.



Second choice but still a good one, especially if your pocket is much smaller.
Tastes much better.


http://www.ncbi.nlm....rm=CHYAWANPRASH

http://www.ayurvedap...yawanprash.html

http://www.iherb.com...anprash&x=0&y=0

[niner]

Anyone know supplements I can take to look younger for longer?

The best thing you can do to be healthy in general, and slow down aging compared to someone eating a typical crappy diet, is to eat a good diet. That means minimize sugar, omega 6-polyunsaturates (industrial seed oils), gluten grains, cured meats and processed food. Eat real food; mostly vegetables, and clean meat; mostly ruminants and fish. Use healthy fats; lots of good olive oil. This is more or less a paleo or pre-industrial diet. Your macronutrient ratio should be on the lower protein side if you want to slow aging. If you are ApoE 2 or 3, then you should get more fat and less carbs than conventional "heart healthy" wisdom suggests. If you are ApoE 4, then go with the conventional wisdom. The odds are about 20-25% that you are ApoE 4. You would need a genetic test to know for sure.

Try to keep your blood sugar in a healthy range all the time. Buy a glucose meter and use it to test your response to different meals.

Use a good sunscreen every day. UV ages your skin more than anything else.

If you smoke, quit. Otherwise don't start.

I'd recommend 1-2g/day fish oil, 1000IU/d vitamin D3, 45-90mcg K2-MK7, 200mg magnesium, 100 mcg selenium, and 150-225mcg iodine.

A good bioavailable silicon supplement, like BioSil or JarroSil, and gelatin are two supplements that may help you look a little better.

[tintinet]

Supplements have a lousy track record WRT health, generally.

As noted above, practices are likely to be more effective. Speculatively, CRON, intermittent fasting, metformin, and omega-3s might help more than hurt.

[Kevnzworld]

Niner, as always gave good advice. I would add the following.
Zinc for prostate health, 30 mg
Testosterone, DHEA ...these are man hormones that decline with age.
Will you live longer , possibly, will your life as an aged man be better ? Yes...

Edited by Kevnzworld, 17 July 2012 - 04:35 AM.

[hamishm00]

I personally think you'll have better chances of living longer if you avoid sunflower oil (PUFA overload - rather focus on olive oil, coconut oil), avoid most nuts (except those with high MUFA content, like macadamias), avoid too much dairy and avoid most grains (especially wheat).

If you want to supplement with vitamin E, take a broad spectrum E supplement (i.e. including all the tocopherols and all the tocotrienols).

Supplements, no matter how natural they are, might do more harm than good. If you are going to take supplements, your best bet for increased health might be (in addition to what niner laid out above) some of the following: green tea, curcumin, resveratrol, Alcar, BCAA, Lysine, Beta-Alanine, creatine, blueberry, cruciferous vegetable extracts and other polyphenols and proanthocyanidins.

[Turnbuckle]

I can't believe no one has mentioned C60. It may not protect against DNA damage, but it certainly seems to reverse aging--at least in some people.

[Junk Master]

C60/OO has been what I'd always hoped CQ10 would be. Huge difference in energy for me at 45. Plus, my hair feels fuller after just six days.

Hopefully, the positives will continue.

I'd also say you can't add enough high quality olive oil to your diet.

Next I'm going to experiment with cold adaptation and Vagus Nerve stimulation to reduce exercise induced inflammation.

[tintinet]

ISTM it might be a bit premature to recommend C60 OO.

[Turnbuckle]

C60/OO has been what I'd always hoped CQ10 would be.

Since mitochondrial DNA replicates as rapidly as every two days and is immersed in a rough environment, full of free radicals and unprotected by a nuclear membrane, it only makes sense to take the supplements that are known to promote its healthy function--eg, C60, PQQ, CoQ10, alcar, and alpha lipoic acid. The mitochondrial theory of aging has the mitochondria going first, and when they do they take down every system in the body.

Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-L-carnitine

Feeding LA/ALC to old rats partially restored age-associated mitochondrial dysfunction to the levels of the young rats. These results indicate that oxidative mitochondrial decay plays an important role in brain aging and that a combination of nutrients targeting mitochondria, such as LA/ALC, could ameliorate mitochondrial decay through preventing mitochondrial oxidative damage.

Edited by Turnbuckle, 17 July 2012 - 04:57 PM.

[niner]

ISTM it might be a bit premature to recommend C60 OO.

I agree, at this stage in the game. Particularly for someone who's young and healthy, and probably won't see a significant difference. For someone who might really be helped by it, and who didn't have much to lose, it would be a great recommendation. I think it would have been a great choice for my elderly father in law when he was dying of congestive heart failure. In a couple years, it might well be my number one recommendation in a case like the OP's. Or, it might join the pantheon of failed supplements that people used to be all excited about.

[nowayout]

Governments have ordered much of the food supply to be fortified with iron to help combat anemia in menstruating females.

That would be a problem if you were eating processed foods, which you should not be eating if you value longevity.

[kurdishfella]

Your dna slow down and enzyme activity decrease as you age. I would take anything that increases energy but creating energy also causes Free radicals. So you want your body to keep the energy level consistent and not high or low.  So Folate and b12 for DNA repair and possibly niacin for energy.

Edited by kurdishfella, 19 April 2021 - 09:15 AM.

[Believer]

Women live nearly a decade longer than men on average, and it's not the estrogen that helps as hormone replacement does not extend their longevity. The reason women live longer is they avoid iron overload throughout much of their lives through menstruation and child birth.

It's proven that estrogen extends health and lifespan.

Women are also more protected against DNA damage du to having two copies of genes.

[Rocket]

It's proven that estrogen extends health and lifespan.
Women are also more protected against DNA damage du to having two copies of genes.

If a man wants to shorten his life then he should definitely increase his estrogen levels.... Increased heart attacks and strokes and depression and alzheimers. In fact men on trt should go onto adex to combat higher estrogen. Estrogen is also linked to prostate cancer and to male breast cancer.

By all means, go ahead and shorten your life and healthspan with estrogen.


You as well recommend cigarettes and big macs.

Edited by Rocket, 22 April 2021 - 01:55 AM.