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Lions Mane and Sleep disorder


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45 replies to this topic

#31 gamesguru

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Posted 31 July 2012 - 12:35 AM

Chrono once recommended this supplier, and I find them reputable: http://www.cordyceps...oom_extract.htm.

Drowsiness without sedation is characteristic of hyperthyroidism (which we might expect to have the same symptoms as bacopa-induced T4-elevation. Bacopa was reported to boost T4 by 41%: [http://www.greenphar...=9;aulast=Gohil]). Re-read this which I quoted: "Patients with hyperthyroidism usually experience fatigue at the end of the day, but have trouble sleeping [properly]".

You're probably taking less bacopa, have developed a tolerance to the thyroid-effects, or are living an otherwise healthier lifestyle. Taking it in the early or late morning, as opposed to the evening, will also make the pro-fatigue anti-sleep properties less noticeable, since it's more difficult to become fatigued/drowsy in the morning, and you're less likely to have issues sleeping after the drug has partially (or largely) worn off (which it probably does as the day drags on, peaking after 3-5 hours, and then returning to baseline within 24-48 hours). Bacopa is NOT sedative, or at least I don't know of any mechanism through which it decreases sleep latency or enhances sleep quality. If anything, the increased T4 will interfere with proper sleep until you develop a tolerance. It returns 5-HT2C receptors to near baseline in epileptic rats, but I don't see why this mild serotonergic activity should correlate to enhanced sleep. Even if it happens to raise healthy people above the baseline 5-HT2C receptor density, it's not at all clear how this would affect sleep quality.

Edited by dasheenster, 31 July 2012 - 01:08 AM.


#32 kevinseven11

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Posted 31 July 2012 - 04:36 AM

Guys, Bacopa is an opioid agonist. Search it.
This causes drowsy type behavior.

Edited by kevinseven11, 31 July 2012 - 04:36 AM.


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#33 renfr

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Posted 23 August 2012 - 05:09 PM

Guys, Bacopa is an opioid agonist. Search it.
This causes drowsy type behavior.

Are you serious? If it was an opioid agonist of any kind it would already be banned, you know how FDAs all around the world are totally paranoid about opioids.
I know it can help with opioid withdrawals but agonize such receptors is unlikely, do you have any research paper about that?


Btw I got my Lion's mane and took 2 tablets of mushroom wisdom (200mg 14:1 extract and 400mg fruiting body with Maitake D fraction) at night 2-3 hours before sleeping, and it appears to cause the same effects that risemystic experienced, I didn't manage to sleep properly, it took me over one hour to start sleeping and my sleep patterns were totally screwed. Then in the afternoon after waking up, I could manage to sleep and slept several hours in the afternoon.
So I guess it acts like a stimulant, at least for me and him, and the best thing would be to take that in the early morning and if that doesn't help, reduce the dosage.

#34 gamesguru

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Posted 23 August 2012 - 07:21 PM

Not 100% conclusive, but definitely suggestive: http://ukpmc.ac.uk/a...report=abstract.

#35 kevinseven11

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Posted 01 September 2012 - 05:27 PM

I have noticed lions mane works much better when taken multiple times through the day! 3 Times a day makes lions mane actually work.

#36 prunk

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Posted 18 September 2012 - 11:54 AM

I also got bad sleep disturbances from Lion's mane. And some strong headaches too. After stopping it took almost 3 days before I was again able to sleep well. The Lion's mane was a powder form (organic) and the dosage was around 1,5g and I took it in the morning with a plenty of water and some cauliflower (vitamin C). I had two trials with it, both 7 days, and results were equal in both occasions.

#37 renfr

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Posted 18 September 2012 - 01:40 PM

I made a Lion's mane overdose and in fact didn't experience serious side effects maybe minor sleepiness.

#38 kevinseven11

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Posted 22 September 2012 - 04:16 PM

I think I know the whole reason..
Vitamin D..
mushrooms all have large amounts of it.
  • Ill informed x 3

#39 prunk

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Posted 22 September 2012 - 06:30 PM

I think I know the whole reason..
Vitamin D..
mushrooms all have large amounts of it.

Do you have any sources to check the levels of Vitamin D in Lion's Mane?

I don't think that's the reason.

Edited by prunk, 22 September 2012 - 06:32 PM.


#40 kevinseven11

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Posted 23 September 2012 - 06:05 PM

http://www.mycoriseu...cium-erinaceus/
100g Serving has 57 UI
If its an extract you should expect to have much more vitamin D.
RDA of vitamin D is 600 UI.
Perhaps you guys have enough sun already or you're sensitive?
  • Ill informed x 2

#41 FunkOdyssey

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Posted 16 February 2015 - 06:09 PM

Also got some bad insomnia from lion's mane, that makes four people reporting it in this thread.  Feels like a clean, non-jittery stimulant, causing me to feel perfectly awake and alert despite the major sleep deprivation it caused.  I took 1g of Host Defense lion's mane a couple hours before bedtime last night.



#42 Hyperflux

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Posted 26 June 2018 - 07:53 AM

ND's 8:1 Lion's Mane extract is really strong stuff. I can't sleep even after using a single 500mg capsule in the morning, I just feel wide awake like modafinil. 



#43 EFTANG

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Posted 06 August 2018 - 08:11 PM

Would you recommend pure mushroom powder or only the extract with active components? If we supplement natural powder how much is the normal dose?

 

 

Only an alcohol extract is relevant according to the most recent research because the NGF-inducers are all alcohol solubles (terpenes) and will not be present in water extracts.

https://www.tandfonl...501201003735556

Since the level is very low to start with (research says ± 0.2% terpenoids in the fruit), taking the raw powder will also have a very limited effect. 

 

On-topic: I've been taking 2 grams daily of the alcohol extract (3% terpenes which includes all NGF-inducers) for a few months now and it has never affected my sleep. 



#44 EFTANG

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Posted 06 August 2018 - 08:18 PM

http://www.mycoriseu...cium-erinaceus/
100g Serving has 57 UI
If its an extract you should expect to have much more vitamin D.
RDA of vitamin D is 600 UI.
Perhaps you guys have enough sun already or you're sensitive?

 

That article is nonsense basically and appears to be a shill for Stamets Host Defense. Don't take that literal.  A mushroom is not a standardised product.

 

It should be extracted because 80% of people cannot digest mushrooms because of the chitin. Chitin locks the active compounds in the cells and you won't benefit unless that chitin is dissolved - the cheapest way is to use hot water extraction or alcohol extraction under high pressure. Extraction will also change the chemical layout to some extent. The final chemical layout should be analysed and specified on the supplement label. IMO if you are a vendor and you leave that out you're deceiving your customers.



#45 Justin BoBustinBananaFanaF

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Posted 26 July 2019 - 09:15 PM

ND's 8:1 Lion's Mane extract is really strong stuff. I can't sleep even after using a single 500mg capsule in the morning, I just feel wide awake like modafinil. 

 

I wonder if the reports on this thread are from NGF increasing histamine. Did any of the wakeful people have allergic type symptoms?



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#46 prunk

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Posted 28 July 2019 - 03:46 PM

I wonder if the reports on this thread are from NGF increasing histamine. Did any of the wakeful people have allergic type symptoms?

I didn't have any.




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