43 replies to this topic

[Turnbuckle]

Fullerenes. At least one company has filed a patent application.

I'm not sure what to make of that patent.

First of all, it's all tissue culture work, nothing in animals.

Secondly, the fact that cells didn't uptake as much lipid after fullerene treatment isn't necessarily a good thing is it? The treatment could have simply damaged the cells.

Also, if there's less lipid uptake wouldn't there be more lipids just floating in the blood? That doesn't sound good either.

The application seemed strange to me too as there is much speculative language in it that would not impress an examiner. It's entirely based on one example of skin cells showing less immune response to a subcutaneous injection of phorbol myristate, and even that is qualitative and falls far short of justifying their first claim. So my guess is this application was filed to get priority. If they see this as big (and it would seem so from the number of inventors) they would have animal work ongoing when they filed and one or more CIP applications by now, while abandoning this one.

[smithx]

OK, I keep reading things like this:
http://www.nytimes.c...6488gBdWLQSwTPw

Tell me again why I shouldn't take aspirin?

I seem to recall that it may play havoc with some part of lipid metabolism. Or some other metabolic pathway. But I can't seem to find it. Vitamin K? I think that was it...

Or maybe it's just great and I should have been taking it all along?

Edited by smithx, 12 December 2012 - 11:16 AM.

[npcomplete]

Definitely K2 (but not K1). Also D3 (at least 5000IU daily). Magnesium citrate (never use the oxide form). And pomegranate extract.
http://www.lef.org/m...egranate_01.htm

...snip...

Perhaps Glisodin might be effective??? LEF has been pumping this in combination with their pomegranate product called "Endothelial Defense™ with Full-Spectrum Pomegranate™ " (I take it and am thinking of dropping the "Glisodin" part and just using pomegranate).

The main article that LEF points to in their hype machine:
http://www.ncbi.nlm....pubmed/17441415

Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.

GliSODin, a vegetal sod with gliadin, as preventative agent vs. atherosclerosis, as confirmed with carotid ultrasound-B imaging.

Cloarec M, Caillard P, Provost JC, Dever JM, Elbeze Y, Zamaria N.

Association Nationale de Prevention Médicale, 14, rue de l'Abbé Grégoire, F-75005 Paris.

Abstract
Prevention of cardiovascular disease should target high-risk subjects based on genetic/familial factors, blood chemistry, blood pressure, body mass index (BMI), and a history of/or current cigarette smoking. We selected active adults (n=76) aged 30-60 and investigated these risk factors, in order to recommend preventive measures. Another interesting variable is the preclinical status or atheroma of the arterial (carotid) wall or lumen. We also investigated the presence of oxidative stress in, and the anti-oxidant status of these subjects. We studied the anti-oxidative efficacy of superoxide dismutase (SOD) and variations of malondialdehyde (MDA). Supplementation with GliSODin, a vegetal SOD associated with gliadin, was effective in controlling the thickness of the carotid artery intima and media layers as measured by ultrasonography-B. We could demonstrate the preventive efficacy of GliSODin at a preclinical stage in subjects with risk factors of cardiovascular disease.
PMID: 17441415

I haven't had any luck finding the full article, but here is a bit more detail with the first page of the article:

http://www.glisodin....loarec_2007.pdf

Basically the study group was a collection of individuals with high blood pressure and poor blood lipid profiles.

[Kevnzworld]

I also take LEF's endothelial defense. I take a pomegranate extract to avoid the fructose in the juice
" Our data suggest that PJ (pomegranate juice ) can exert beneficial effects on the evolution of clinical vascular complications, coronary heart disease, and atherogenesis in humans by enhancing the NOSIII bioactivity."
http://www.sciencedi...089860305001825
This study showed that PFE ( pomegranate fruit extract ) is as effective as juice
"Furthermore, the effect of PFE in increasing endothelial NO synthase (eNOS) expression was comparable to that of PJ. These data highlight possible clinical applications of PFE in metabolic syndrome."
http://www.sciencedi...089860307000432

Regarding aspirin, it's an anti inflammatory , anti platelet aggregating drug, so it works. It's also helps slightly in cancer prevention .
http://www.scienceda...20810193751.htm

[Logic]

Pycnogenol

Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study.
http://www.ncbi.nlm....pubmed/22240497
Easy read:
http://www.naturalhe...g/nhri/?p=18283

Impact of Pycnogenol on cardiac extracellular matrix remodeling induced by L-NAME administration to old mice.
http://www.ncbi.nlm....pubmed/17646678

http://www.lef.org/m...cnogenol_02.htm

Healthy Arteries and Pycnogenol: An Interview with Frank Schönlau, Ph.D.
http://www.wholefood...-frank-schonlau

Ignore all the previous advice I gave here; its all just crap I sucked out my thumb!

[MrHappy]

http://www.longecity...therosclerosis/

Red palm oil and tocotrienols reversing clogged arteries.

[daouda]

EDTA has also been talked about to remove arterial plaque but there's a lot of controversy about it (I think its mostly considered ineffective or dangerous, but its worth googling it)

[Turnbuckle]

EDTA has also been talked about to remove arterial plaque but there's a lot of controversy about it (I think its mostly considered ineffective or dangerous, but its worth googling it)

EDTA has been shown to be useful in getting rid of heavy metals, but not necessarily good for cardiovascular disease. One worry was that it might damage the kidneys, but that has been shown not to be the case--

One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplements. Following 20 infusions, creatinine clearance [a measure of kidney function] significantly improved. This report adds credence to the findings of those physicians who have noted that EDTA is a safe and major therapeutic modality in the treatment of chronic cardiovascular diseases. The patients reported in this experiment represent a small part of a much larger group of several hundred individuals undergoing a series of tests to determine the utility of EDTA therapy in subjects with occlusive vascular disorders.

http://www.ncbi.nlm..../pubmed/6441110

Edited by Turnbuckle, 14 December 2012 - 03:53 PM.

[niner]

EDTA has been around for a long time, and a lot has been written about it, particularly in the netherworld of the net. Here's a fairly new review of the science on it. Looks like it doesn't work particularly well, but isn't super dangerous either. In this much newer paper, they did catch a case of increased creatinine and a couple cases of hypocalcemia. I think if it's used with appropriate blood testing, it would be ok, but I wouldn't recommend cowboy medicine with this agent.

BMC Cardiovasc Disord. 2005 Nov 1;5:32.
EDTA chelation therapy for cardiovascular disease: a systematic review.
Seely DM, Wu P, Mills EJ.

Canadian College of Naturopathic Medicine, Toronto, Canada. dseely@ccnm.edu

BACKGROUND:

Numerous practitioners of both conventional and complementary and alternative medicine throughout North America and Europe claim that chelation therapy with EDTA is an effective means to both control and treat cardiovascular disease. These claims are controversial, and several randomized controlled trials have been completed dealing with this topic. To address this issue we conducted a systematic review to evaluate the best available evidence for the use of EDTA chelation therapy in the treatment of cardiovascular disease.
METHODS:

We conducted a systematic review of 7 databases from inception to May 2005. Hand searches were conducted in review articles and in any of the trials found. Experts in the field were contacted and registries of clinical trials were searched for unpublished data. To be included in the final systematic review, the studies had to be randomized controlled clinical trials.
RESULTS:

A total of seven articles were found assessing EDTA chelation for the treatment of cardiovascular disease. Two of these articles were subgroup analyses of one RCT that looked at different clinical outcomes. Of the remaining five studies, two smaller studies found a beneficial effect whereas the other three exhibited no benefit for cardiovascular disease from the use of EDTA chelation therapy. Adverse effects were rare but those of note included a few cases of hypocalcemia and a single case of increased creatinine in a patient on the EDTA intervention.
CONCLUSION:

The best available evidence does not support the therapeutic use of EDTA chelation therapy in the treatment of cardiovascular disease. Although not considered to be a highly invasive or harmful therapy, it is possible that the use of EDTA chelation therapy in lieu of proven therapy may result in causing indirect harm to the patient.

PMID: 16262904 http://www.ncbi.nlm....pubmed/16262904 Free Full Text

[Logic]

EDTA has been shown to be useful in getting rid of heavy metals, but not necessarily good for cardiovascular disease. One worry was that it might damage the kidneys, but that has been shown not to be the case--

One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplements. Following 20 infusions, creatinine clearance [a measure of kidney function] significantly improved. This report adds credence to the findings of those physicians who have noted that EDTA is a safe and major therapeutic modality in the treatment of chronic cardiovascular diseases. The patients reported in this experiment represent a small part of a much larger group of several hundred individuals undergoing a series of tests to determine the utility of EDTA therapy in subjects with occlusive vascular disorders.

http://www.ncbi.nlm..../pubmed/6441110

I have done a little research on chelation and AGEs etc. There deff seems to be a link.
Worth checking out...

[Kevnzworld]

Here's a new placebo controlled human study that shows aged garlic extract and CoQ10 lower inflammation ( CRP ), and reduce atherosclerotic progression.

Quote : " Participants taking AGE and CoQ10 combination were found to have significant improvements in CAC and CRP, suggesting improvement in cardiovascular health. " Conclusion:
AGE+CoQ10 are associated with beneficial effects on inflammatory markers and reduced progression of coronary atherosclerosis.

http://www.ncbi.nlm....les/PMC3425023/

Edited by Kevnzworld, 15 December 2012 - 01:34 AM.

[smithx]

Why would aged garlic work better than fresh garlic?

Also: that study was funded by Wakunaga of America, the manufacturer of the aged garlic.

[Luminosity]

In the long term I would advocate diet to address this disease. A normal diet, not high fat, with healthy fat, no transfats. Organic or free range eggs, dairy and chicken. Avocado, nuts and seeds. Plenty of fruits and vegetables. Low sugar. Low in fried foods. Exercise, if you can do it safely.

Puerh tea may help, if it agrees with you. It is an aged black tea that dissolves cholesterol. Drink it hot and plain. Do not overdo. You can decafienate it by steeping the tea bag in a little hot water for one minute, discarding that water and then making tea with that tea bag. You can mail order it from Swanson's or Vitacost.com.

Vitamin's D and K sound like good choices.

[Kevnzworld]

Why would aged garlic work better than fresh garlic?

Also: that study was funded by Wakunaga of America, the manufacturer of the aged garlic.

The garlic is aged and dried to concentrate,extract and standardize it. It also makes it odorless.
The CoQ10 component is important.
The science on garlic goes way back.
Quote : "
" Epidemiological study shows an inverse correlation between garlic consumption and reduced risk of cardiovascular disease progression [180–182]. The wealth of scientific literature supports the proposal that garlic consumption have significant cardioprotective effect, which include both animal and human studies "

http://www.nutrition...m/content/1/1/4