6 replies to this topic

[ta5]

Rxlist and webmd have a warning about L-Threonine having an interaction with NMDA antagonists, namely Memantine. Does anyone know what's going on there? Is L-Threonine an NMDA agonist?

Medications used for Alzheimer's disease (NMDA antagonists)
Interaction Rating: Major Do not take this combination.
There is some concern that threonine might decrease how well a medication used for Alzheimer's disease works. This medication is called memantine (Namenda).

[ScienceGuy]

Rxlist and webmd have a warning about L-Threonine having an interaction with NMDA antagonists, namely Memantine. Does anyone know what's going on there? Is L-Threonine an NMDA agonist?

Medications used for Alzheimer's disease (NMDA antagonists)
Interaction Rating: Major Do not take this combination.
There is some concern that threonine might decrease how well a medication used for Alzheimer's disease works. This medication is called memantine (Namenda).

My two cents: It is interesting to note that MAGNESIUM L-THREONATE comprises L-THREONINE combined with MAGNESIUM, an NMDA ANTAGONIST, without any apparent issues whatsoever; wherein, the claimed NOOTROPIC EFFECT of MAGNESIUM L-THREONATE is reported to be specifically due to its NMDA ANTAGONISM... this is indicative that such a cancellation effect / interaction does not in fact occur between L-THREONINE and NMDA ANTAGONISTS in general, but perhaps exclusively with MEMANTINE, if that is indeed the case (N.B. "some concern" does not = conclusive proof). Accordingly, if L-THREONINE does indeed reduce the efficacy of MEMANTINE then it is probable that this is through some other mechanism of action that is specifically related to MEMANTINE and not NMDA ANTAGONISTS in general.

N.B. Hence, the reason why RXLIST and WEBMD list "(NMDA antagonists)" is likely simply because they have to categorize MEMANTINE and "NMDA antagonist" is the 'box / drop down menu selection' into which MEMANTINE fits...

Edited by ScienceGuy, 11 November 2012 - 10:22 AM.

[ta5]

My two cents: It is interesting to note that MAGNESIUM L-THREONATE comprises L-THREONINE combined with MAGNESIUM...

According to Wikipedia, Magnesium L-Threonate comprises the salt of L-Threonic Acid combined with Magnesium. Threonic acid is a sugar acid derived from Threose, and L-Threose is a metabolite of Vitamin C. Threose is a four-carbon monosaccharide or carbohydrate with molecular formula C4H8O4.

But I know, it sounds like it should be Threonine since Magnesium Glycinate is Glycine, and Magnesium Taurinate is Taurine.

My question wasn't related to Magnesium L-Threonate. I'm really wondering about L-Threonine, the amino acid.

Edited by ta5, 11 November 2012 - 03:57 PM.

[ScienceGuy]

My two cents: It is interesting to note that MAGNESIUM L-THREONATE comprises L-THREONINE combined with MAGNESIUM...

According to Wikipedia, Magnesium L-Threonate comprises the salt of L-Threonic Acid combined with Magnesium. Threonic acid is a sugar acid derived from Threose, and L-Threose is a metabolite of Vitamin C. Threose is a four-carbon monosaccharide or carbohydrate with molecular formula C4H8O4.

But I know, it sounds like it should be Threonine since Magnesium Glycinate is Glycine, and Magnesium Taurinate is Taurine.

My question wasn't related to Magnesium L-Threonate. I'm really wondering about L-Threonine, the amino acid.

Ah, my apologies... please kindly forgive BRAIN FART due to posting here after a 36-hour day... time to get some shuteye...

...either that or take another dose of COLURACETAM to wake up my brain

Edited by ScienceGuy, 11 November 2012 - 08:08 PM.

[dear mrclock]

My two cents: It is interesting to note that MAGNESIUM L-THREONATE comprises L-THREONINE combined with MAGNESIUM...

But I know, it sounds like it should be Threonine since Magnesium Glycinate is Glycine, and Magnesium Taurinate is Taurine.

uh all those are also magneisum, i know the glycinate, taurinate forms added to magnesium it is to help its bioavailability, specically bypass the BBB. how are they anything but magnesium ? you need grams of those amino acids, and its barely a milligram combined with magnesium.

[ta5]

uh all those are also magneisum, i know the glycinate, taurinate forms added to magnesium it is to help its bioavailability, specically bypass the BBB. how are they anything but magnesium ? you need grams of those amino acids, and its barely a milligram combined with magnesium.

There's some confusion. My question is not about magnesium.

[dear mrclock]

there is no confusion. check mg of amount present in each mg magneisum is present type of tablet, capsule w/e, its way way too little as an amino acid to be effective. it seems to me that, amino acids have special ability to cross BBB and hit certain spots in the brain and deliver whatever it is attached to them (in case magneisum) hence why magneisum is only psychologically bioavalable when combined with small amount of transporter amino acids. the rest of magneisum seems to be mostly abosrbed and expressed throughout the body that is not the brain.