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[medievil]

One is available:

Bethanechol


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Bethanechol Systematic (IUPAC) name 2-(carbamoyloxy)- N,N,N-trimethylpropan- 1-aminium Clinical data Trade names Urecholine AHFS/Drugs.com monograph MedlinePlus a682849 Pregnancy cat. C (US) Legal status ? Routes Oral, subcutaneous Identifiers CAS number 674-38-4 ATC code N07AB02 PubChem CID 2370 IUPHAR ligand 297 DrugBank DB01019 ChemSpider 2280 UNII 004F72P8F4 KEGG C06850 ChEBI CHEBI:3084 ChEMBL CHEMBL1482 Synonyms 2-[(aminocarbonyl)oxy]-N,N,N-trimethyl- 1-propanaminium Chemical data Formula C₇H₁₇N₂O₂ Mol. mass 161.221 g/mol

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Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect onnicotinic receptors. Unlike acetylcholine, bethanechol is not hydrolyzed by cholinesterase and will therefore have a long duration of action. Bethanechol is sold under the brand names Duvoid (Roberts), Myotonachol (Glenwood), Urecholine (Merck Frosst) and Urocarb (Hamilton).
[edit]Uses

Bethanechol is sometimes given orally or subcutaneously to treat urinary retention resulting from general anesthetic or diabetic neuropathy of the bladder, or to treat gastrointestinal atony (lack of muscular tone). The muscarinic receptors in the bladder andgastrointestinal tract stimulate contraction of the bladder and expulsion of urine, and increased gastrointestinal motility, respectively. Bethanechol should be used to treat these disorders only after mechanical obstruction is ruled out as a possible cause.
Its potential benefit in the treatment of cerebral palsy has been investigated.^[1] Bethanechol is a powerful cholinergic agent which efficiently crosses the blood - brain barrier and may have powerful nootropic properties in enhancement of neural signaling and processing speed as well.
Atropine is given preoperatively to prevent voiding of the bowel/bladder during surgery, Bethanechol is then given postoperatively to revert this action.^[2]

Not sure wich muscarinic receptor it agonizes to see what uses it can have, i need to do so pubmedding on this one.

[jadamgo]

Or check it out at the PDSP Ki database

[medievil]

I dont understand that at all, im a good example of how intelligence can come in differened ways, there's no way im ever gonna be able to properly understand that shit while i do need to know the affinity's of a ton of stuff.

[jadamgo]

Oh, well it turned out to only have affinity data for the M1 receptor anyway. Oh well. (190 nM.)

[spermidine]

thats all there is ? one muscarinic agonist ?

it seems unsafe tho. anyone tried it ? says best for threating urinary retention. i dont see much point in it overall. and it doesnt say to be RX, so its easy to acquire it anywhere ??

Edited by spermidine, 19 February 2013 - 03:24 AM.

[gintrux]

anybody tried Bethanechol?