11 replies to this topic

[spermidine]

guys i have been looking into IGF-1 as nootropic. i have read it can help a lot with that. specifically mentions neurogenesis and also from wiki it mentions it also helps with;
"IGF-1 then stimulates systemic body growth, and has growth-promoting effects on almost every cell in the body, especially skeletal muscle, cartilage, bone, liver, kidney, nerves, skin, hematopoietic cell, and lungs. In addition to the insulin-like effects, IGF-1 can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis"

wow thats crazy with how much it can help ! dont you think thats amazing ? i was thinking, either taking it by itself which seems legal, or perhaps get deer antler which claims to have IGF-1 for all those benefits ? what do you guys think, good idea ? i just wish someone helps me out here with if this is such a good. because i also read cancer occurs exactly because of IGF-1 ! so thats pretty fucked up. so many benefits can be scraficed for cancer :/

anyone ever took anything related like deer antler and noticed a difference ? please help me out with this !

[spermidine]

found resveratrol to increase production of IGF;

http://www.ncbi.nlm....pubmed/21295960


resveratrol seems to increase production but it is said it prevents cancer. so how does increasing production of IGF which is known to cause cancer, actually prevents it now ?

[megatron]

Read this: http://forums.steroi...t=#.USdVD6WTx1c

[Nordmann]

Intermittent fasting like www.leangains.com increases IGF-1, this has 16hour fast and 8hour feeding

But there are speculation that IGF-1 increases the risk of cancer and aging.

This guy, Michael Mosley actually uses another kind of fasting to decrease IGF-1.

View on Dailymotion

I know, my head is full of WTF too But I really enjoy`s the Leangains approach it`s easy and have very positive effects. Leangains kinda woke me up. Better mind and body. Never been sick since and I was often sick. Startet around one year ago.

Yeah, and btw there is always an risk of aging, but I ment faster aging

Edited by Anders Jonassen, 22 February 2013 - 12:49 PM.

[spermidine]

wait you mention that fasting actually increases IGF and then you say that it actually decreases it. im confused now...

[Nordmann]

wait you mention that fasting actually increases IGF and then you say that it actually decreases it. im confused now...

Hehe, thats what I meant with the WTF :P

There are different kind of fasting.

Leangains are hourly based, 16 hours without food and a 8 hour window with feeding.

Michael Mosley i think uses something like the STOP EAT STOP program, 24 hours without food and 24 with. Correct me if I`m wrong, some month`s since I saw the documentary.

It`s kinda wierd that something so similar can create so different outcomes.

I have not read any science backing this up. But Michael from BBC and Martin from leangains are people who rely on science and should have available for those who are interested. Especially Martin, it`s probably in his blog somewhere. It`s a jungle in there

[spermidine]

yeh ok tnx for clarifying it.

i also want confirmation if milk actually contains IGF-1 ? logically it should but i never see any mention of it anywhere. it must be that it does but probably not in enormous amount.

[scottknl]

yeh ok tnx for clarifying it.

i also want confirmation if milk actually contains IGF-1 ? logically it should but i never see any mention of it anywhere. it must be that it does but probably not in enormous amount.

From http://onlinelibrary...ajhb.22201/full

The other component that has received more recent attention is insulin-like growth factor I (IGF-I), part of the protein fraction in milk. IGF-I has mitogenic properties, inducing cell division and proliferation, and preventing apoptosis. It is both found in milk and produced endogenously in the liver and other tissues such as bone, where it is the most abundant growth factor. Hepatic and tissue production of IGF-I is stimulated by pituitary growth hormone, insulin, and is also influenced by diet and nutritional status. Given that IGF-I is produced by the neonate and is active in many tissues, it is not entirely clear what function the IGF-I in milk has; it may support the growth and development of the neonatal gastrointestinal tract or enhance lactase activity, but evidence is equivocal as to whether it is absorbed intact and thus able to exert systemic effects (Burrin, 1997).
Despite a threefold difference in total protein, cow milk does not contain more IGF-I than human milk, and bovine and human IGF-I are molecularly identical (Campana and Baumrucker, 1995; Koldovsky and Strbak, 1995). Circulating IGF-I levels rise after milk consumption (Holmes et al., 2002), and children who drink more milk, but not those who consume higher amounts of other forms of animal protein, have higher circulating IGF-I levels (Cadogan et al., 1997; Hoppe et al., 2004a, b; Qin et al., 2009; Zhu et al., 2006). Debate continues over whether the rise in serum levels is due to the IGF-I in milk or whether milk stimulates endogenous production through a process that has yet to be described (Holmes et al., 2002; Juskevich and Guyer, 1990; Rich-Edwards et al., 2007). It appears that the casein portion of milk protein, rather than whey protein, is most closely related to rises in circulating IGF-I after milk consumption (Hoppe et al., 2009). Interestingly, diets high in milk and dairy products in childhood are associated with lower IGF-I in adulthood, suggesting that the short- and long-term effects of milk intake may vary by life history stage (Ben-Shlomo et al., 2005; Martin et al., 2007). Furthermore, as there are periods of rapid and slow growth, there may be critical periods during which milk may raise IGF-I levels and contribute to growth, and these feed back over the long term to reduce IGF-I production via pituitary secretion of growth hormone (Martin et al., 2011). In any event, while current attention is focused on IGF-I, given milk's complexity and is role in mammalian life history, it likely interacts with several other milk components, including calcium, and individual genotypes to affect growth and development.

[spermidine]

yeh i thought so much. it seems tho, at least from what i have observed, consumption of milk in old age is positvely associated with cancer perhaps relation to IGF-1 ? i checked a map of highest consumption of milk in the world, the longest living people which are located in isolated asian teritories do not consume milk at all. while the highest consumers of milk, australia, usa and many parts of europe, do have high rise in cancer. from what i believe, perhaps, IGF-1 is important component in milk and should be avoided in aging individuals BUT be supplemented as much as possible in childhood.


simple wiki entry; " In Australia and in Ireland there was a government funded "free milk for school children" program, and milk was distributed at morning recess in 1/3 pint bottles" which are 2nd and 3rd in cancer cases.

CHECK

http://cdn3.chartsbi...c3d59c6d96f7d9c


AND MATE


http://www.guardian....s-uk-rate-drops

Edited by spermidine, 26 February 2013 - 07:14 PM.

[kurdishfella]

Why would the IGF-1 in milk be absorbed when you drink it? I'm pretty sure it isn't absorbed that's why you inject it like with other hormones (testosterone,hgh etc).

Edited by farshad, 28 October 2019 - 11:05 PM.

[Rocket]

IGF-1 is destroyed by digestion. It needs to be injected into muscle for best absorption unlike many other peptides that can be subQ. Also, HGH has a feedback system like testosterone so that when a person uses exogenous HGH, the bodies own production is slowed or stopped. That would be the case even IF it was absorbed with food which it absolutely is not. Exogenous growth hormone has to be used in a quantity greater than the body produces or else the person is just replacing internally produced growth hormone with externally supplied hormone because of the feedback system.

 

 

[Believer]

Any androgen receptor agonist that binds to androgen receptors in the liver and elsewhere, will, depending upon how strong an agonist it is, significantly elevate igf-1 BLOOD levels.

Testosterone for example in very cheap (not small) dosages of 600mg very significantly elevates igf-1 according to studies.

MK677 also siginficantly elevates igf-1 BLOOD levels.

Remember there is a difference between BLOOD levels and TISSUE levels. Igf-1 levels are regulated in all tissues.

 

You can actually mentally feel the effects of mk677. Better sleep for example.