12 replies to this topic

[spermidine]

"Recently, amitriptyline has been demonstrated to act as an agonist of the TrkA and TrkB receptors.^[26] It promotes the heterodimerization of these proteins in the absence of NGF and has potent neurotrophic activity both in-vivo and in-vitro in mouse models.^[26][27] These are the same receptors BDNF activate, an endogenous neurotrophin with powerful antidepressant effects, and as such this property may contribute significantly to its therapeutic efficacy against depression. Amitriptyline also acts as FIASMA (functional inhibitor of acid sphingomyelinase)"


isnt this one of the best positive influences from antidepressant you know ? look at this ! some pretty good nootropic effect for sure ! was aiming for people's response who have tried it tho because thats the only way to know exactly how all this fit in actual regular usage.

[Reformed-Redan]

The anticholergenic properties of amitriptyline will negate any other nootropic qualitites it may have. It's also a old tricyclic that from, what I've read, has more side effects than the SSRI's. Tricyclics also affect histamine, making them more sedating than the SSRI's.

[spermidine]

man i understand tricyclics are outdated and mostly SSRi's have replaced them in popular consumption and tolerance to side effects but did you read all those descriptions based on nootropic qualities i quoted ? thats a lot. doubt the negative can really completely abolish so much. but i guess maybe, perhaps new modern versions of amitriptiline can have all those positives with much less negatives.

[Reformed-Redan]

man i understand tricyclics are outdated and mostly SSRi's have replaced them in popular consumption and tolerance to side effects but did you read all those descriptions based on nootropic qualities i quoted ? thats a lot. doubt the negative can really completely abolish so much. but i guess maybe, perhaps new modern versions of amitriptiline can have all those positives with much less negatives.

There are far better ways of increasing BDNF levels than using tricyclics. Certain flavenoids will do the trick. High doeses of Zinc will also. Melatonin and Buspar may also ellicit increases in BDNF. BDNF alone isnt a good nootropic. Some studies show it's necessary in the right levels for memory formation other studies show high levels of BDNF can impair memory formation. Check for yourself:

http://www.longecity...rophic-factors/
http://www.longecity...hing-bad-thing/
http://www.longecity...hing-bad-thing/
http://www.longecity...-increase-bdnf/

[spermidine]

^ amitriptyline has been demonstrated to act as an agonist of the TrkA and TrkB receptors

i dont see BDNF in there buddy. if you click urls as provided, those are interesting, powerful places to stimulate.

[nowayout]

The anticholergenic properties of amitriptyline will negate any other nootropic qualitites it may have. It's also a old tricyclic that from, what I've read, has more side effects than the SSRI's. Tricyclics also affect histamine, making them more sedating than the SSRI's.

Being sedating can be a good thing for anxious depression and the accompanying insomnia.

[Reformed-Redan]

The anticholergenic properties of amitriptyline will negate any other nootropic qualitites it may have. It's also a old tricyclic that from, what I've read, has more side effects than the SSRI's. Tricyclics also affect histamine, making them more sedating than the SSRI's.

Being sedating can be a good thing for anxious depression and the accompanying insomnia.

Remeron, would be a better option if you want sedation. I'm sure Amitriptyline has its uses. They are still some of the most powerful drugs for depression.

[spermidine]

so you would recomend as a good antidepressant someone take remeron instead ? i checked what it affects, and its not specific. seems to affect absolutely every receptor there is at some affinity.

[Reformed-Redan]

so you would recomend as a good antidepressant someone take remeron instead ? i checked what it affects, and its not specific. seems to affect absolutely every receptor there is at some affinity.

I don't "recomend" anything, if you know what I mean. But, antidepressants are not really known for nootropic qualities unless you have depression.

[spermidine]

actually there are a lot of studies relation to serotonin reuptake inhibition and nootropic qualities. but i guess its stupid to take them for that alone if you do not really need them.
was just curious about this specific one because i have not seen any substance as of yet to be agonist of the TrkA and TrkB receptors. but its probably negligable anyway and of no significant interest.

[kurdishfella]

The anticholergenic properties of amitriptyline will negate any other nootropic qualitites it may have. It's also a old tricyclic that from, what I've read, has more side effects than the SSRI's. Tricyclics also affect histamine, making them more sedating than the SSRI's.

can't you just take Nicotine or something to offset that?

[NG_F]

Nortriptyline  is much better in terms of what you're looking for . Desipramine may be a close second, Desipramine is amazing for neuropathic pain and has virtually Zero anti cholinergic or anti-histaminergic properties

[kurdishfella]

sorry for bumping again, but I was thinking of getting amitriptyline instead of semax and lions mane since I believe it would work better on BDNF and ngf than the latter two on those things respectively , can someone give thoughts on this? is it a good option/ or alternative? 

 

and how can I fix the amitriptyline anticholergenic side effect? with galantamine perhaps?

Edited by kurdishfella, 24 March 2020 - 12:47 AM.