6 replies to this topic

[YOLF]

I did some searching and I'm having trouble figuring out which of these products is the better buy. One has 500IU of GliSODin, and the other has 2000 activity units as defined by McCord & Fridovich units. How do I know which one is better to buy?

Products I'm looking at:
http://www.vitacost....xidant-catalyst
http://www.vitacost....oxide-dismutase

[EFTANG]

An old post, but I happen to know the answer.

 

Only the Glisodin SOD product is useful, because it will pass the stomach acid barrier. 

 

SOD is using gliasin (a component of gluten) as a carrier to form Glisodin. The other product is uncoated SOD which is useless because it will be destroyed in in the stomach. See this research abstract for comparison tests, and this full-text article for in-depth information.

[YOLF]

Unless the extramel SOD is breaking down into something toxic when it hits my stomach acid, I have to think that it is being absorbed b/c I get headaches if I take too much of it. What do you think?

[niner]

What's "extramel SOD"?  Are you talking about the non-gliadin version?  If it gives you a headache, that might be due to an additive rather than the protein.  I suppose it's possible (but unlikely) that you're allergic to whatever form of SOD they're using.  It seems unlikely to me that naked SOD would work as an oral dosage form.

[YOLF]

Extramel is an extractive of melon rinds that contains SOD. It is perhaps bound to some other material coming from the rinds. It does get absorbed and used very quickly as I understand. B/c glisodin is absorbed more quickly and used more slowly it lasts longer and reaches higher peak levels, but they both work IMO. Glutathione is absorbed into tissue very quickly and reaches crazy levels in tissues, but its impact is virtually undetectable in the blood stream.

[EFTANG]

Extramel is an extractive of melon rinds that contains SOD. It is perhaps bound to some other material coming from the rinds. It does get absorbed and used very quickly as I understand. B/c glisodin is absorbed more quickly and used more slowly it lasts longer and reaches higher peak levels, but they both work IMO. Glutathione is absorbed into tissue very quickly and reaches crazy levels in tissues, but its impact is virtually undetectable in the blood stream.

 

 

This research does not agree with you on this - the paper states "The effects of supplementation for 28 days with a standardized melon SOD extract either combined (Glisodin) or not with gliadin, were evaluated on various oxidative-stress biomarkers. As already described there was no change either in superoxide dismutase, catalase or glutathione peroxidase activities in blood circulation or in the liver following non-protected SOD supplementation."

[YOLF]

Hmmm, I didn't buy the article, but if the abstract is straight forward then this is what I'm lead to think:

Rapid uptake of MelSOD, if it occurs (the information I saw showed a sudden initial spike of SOD that disappeared quickly compared to GliSODin which maintained peak levels for hours) is negated by transient levels. So what we're seeing is something similar to Ester-C, lower sustained levels are loads more effective for cell health than mostly useless transient spikes. 

 

So do you think GliSODin is advisable/effective/more long lasting in celiacs? I haven't tried it.

 

I should note however, that I attempt to slow the absorption of the cheap SOD with the rest of my supplement cocktail. I don't really use it much these days except for mixing into DIY skin care.