I've been reading about Amantadine and it's modes of action. It inhibits dopamine and norepinephrine reuptake and also releases them, inhibits MAO-A, acts as a weak antagonist at the NMDA glutmate receptor and raises beta-endorphin/beta-lipotropin levels. I also found some small studies that produced favorable results in patients suffering from depresison.
It looks good on paper, but there's a very serious side effect that's uncommon, but brings up lots of results when searched for in Google. Amantadine can cause Livedo reticularis. Most of the time it's temporary, but in some cases it can be permanent.
What do you guys think of this? Here's a study that documented Livedo reticularis during treatment with Amantadine.
ivedo reticularis is a common side effect of treatment with amantadine for Parkinson's disease. Investigation of 40 such patients suggests that the livedo is a physiological response provoked by depletion of catecholamine stores in peripheral nerve terminals.
Any way to counter this?