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Scientists find the brain region that controls ageing

aging

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#1 Dominicus

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Posted 03 May 2013 - 05:52 PM


http://www.dailymail...turn-clock.html

Researchers believe that the hypothalamus – the area of the brain which controls hunger, thirst, body temperature and fatigue - may be the ‘fountain of ageing’, controlling how the body declines over time.
They say they have discovered a specific age-related signalling pathway which opens up new strategies for combating diseases of old age and extending lifespan.

However, they also found that blocking the pathway in the hypothalamus of mouse brains slowed ageing and increased longevity by about 20 per cent.


Suspecting that reduced release of GnRH from the brain might contribute to whole-body ageing, the researchers injected the hormone into aged mice and made the striking observation that the hormone injections protected them from the impaired neurogenesis – creation of new neurons - associated with ageing.
When aged mice received daily GnRH injections for a prolonged period, the therapy exerted benefits that included the slowing of age-related cognitive decline, probably the result of neurogenesis.
Professor Cai said preventing the hypothalamus from causing inflammation and increasing neurogenesis via GnRH therapy are two potential strategies for increasing lifespan and treating age-related diseases.


All we have to do is find extracts or natural substances that increase GnRH in the Brain. First thing that came to mind was the Indium thread from a while back. I wonder if that was having a direct impact on the hypothalamus.

#2 Dominicus

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Posted 03 May 2013 - 06:25 PM

They found that a chemical called NF-kB became more active in the hypothalamus of mice as they got older. When the researchers blocked the substance, mice lived up to 1,100 days, compared with 600 to 1000 days for normal healthy mice. When they boosted NF-kB in mice, they all died within 900 days.
Tests on the animals six months into the study found that those without NF-kB had more muscle and bone, were better at learning, and had healthier skin than controls.
Further work showed that NF-kB lowered levels of a hormone called GnRH, which is better known for the central role it plays in fertility and the development of sperm and eggs.


Well I found 2 substances that block NF-kB.

BHT and Curcumin

BHT Source: http://www.ncbi.nlm....pubmed/17067360

Butylated hydroxytoluene reduced binge-induced NF-kappaB-DNA binding and COX2 expression.
CONCLUSIONS:

Binge-induced brain damage and activation of NF-kappaB-DNA binding are blocked by BHT. These studies support a neuroinflammatory mechanism of binge ethanol-induced brain damage.


Curcumin Source: http://www.ncbi.nlm....pubmed/10477620

The food derivative curcumin has been shown to inhibit NF-kappa B activity in some cell types.



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#3 Guardian4981

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Posted 03 May 2013 - 07:34 PM

Don't depressed people have smaller hypothalamus areas?
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#4 Dominicus

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Posted 03 May 2013 - 07:36 PM

I'm not depressed so I wouldn't know.

My interest is to slow aging.
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#5 Hebbeh

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Posted 03 May 2013 - 08:15 PM

Don't depressed people have smaller hypothalamus areas?


You're confused with hippocampus.

This has been discussed here...

http://www.longecity...ng/#entry584147
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#6 meatsauce

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Posted 04 May 2013 - 10:42 PM

I have read studies saying that naltrexone, a u opioid antagonist, increases release of gnrh from the hypothalamus. People report having a high libidos while using a low dose at night. Low dose naltrexone therapy - I will be using this soon.

#7 hippocampus

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Posted 05 May 2013 - 12:02 PM

I'm not depressed so I wouldn't know.

lol like you need to be depressed to know this :)
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#8 Dominicus

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Posted 06 May 2013 - 06:41 PM

I'm not depressed so I wouldn't know.

lol like you need to be depressed to know this :)

Lol ...just realized that the response does sound funny come to think.

What I meant is that when I read studies and research supplements, I tend to skip over anything that discusses depression and jump straight to longevity/anti-aging effects.

ALCAR has been an awesome mood and energ enhancer. I swear by it. Found myself whisteling and being much MUCH more happier in lifer after taking that daily.

#9 nootrope

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Posted 07 May 2013 - 03:34 AM

Ashwagandha also inhibits NF-kB in some cells.

http://www.ncbi.nlm....pubmed/17562568

Perhaps boswellia as well?

http://www.ncbi.nlm....pubmed/19752240
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#10 cATsE

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Posted 15 May 2013 - 08:01 AM

Read about this on a Dutch forum too the other day, there's also a link to a paper on nature.com, which I can't post since I don't have enough posts. :)

Anyway, I did a search here on Longecity and a lot of results for NF-kB came up, even dating back as far as 2008 so I'm pretty sure it's not all that new.

Currently looking into a possible relationship with taking c60, seem to be quite a few posts about that here.

Well I found 2 substances that block NF-kB.

BHT and Curcumin


Isn't BHT the same stuff some use to prevent oils and oily foods (nut and peanut butters, for example) from going rancid? But shouldn't it be able to cross the blood-brain barrier to be of any use here?


I

#11 cATsE

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Posted 15 May 2013 - 08:01 AM

Read about this on a Dutch forum too the other day, there's also a link to a paper on nature.com, which I can't post since I don't have enough posts. :)

Anyway, I did a search here on Longecity and a lot of results for NF-kB came up, even dating back as far as 2008 so I'm pretty sure it's not all that new.

Currently looking into a possible relationship with taking c60, seem to be quite a few posts about that here.

Well I found 2 substances that block NF-kB.

BHT and Curcumin


Isn't BHT the same stuff some use to prevent oils and oily foods (nut and peanut butters, for example) from going rancid? But shouldn't it be able to cross the blood-brain barrier to be of any use here?


I

#12 Logic

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Posted 15 May 2013 - 11:10 AM

A most remarkable study was performed by the Centre for Phytomedicine Research - a research division of the Department of Botany at the University of Fort Hare, located in Alice, South Africa. In this study, subjects were given Bulbine natalensis extract and then were evaluated to determine what effect Bulbine natalansis extract has on various sex hormone levels, including testosterone, estrogen, and prolactin. The results were literally astonishing; something bodybuilders only dream about. Subjects in this study demonstrated a resulting serum testosterone level that was 347% greater than that of the control group, and with an estrogen level that was 35% lower!


Researchers have also concluded that Bulbine natalensis extract increases gonadotropin-releasing-hormone-luteinizing hormone (GnRH-LH) signaling. GnRH is released from the hypothalamus in the brain. GnRH stimulates the release of luteinizing hormone (LH) from the pituitary. LH is the hormone that directly stimulates cells in the testes to produce and release testosterone. Bulbine natalensis extract has also been shown to stimulate LH by 169%, as compared to placebo!

http://www.a1supplem...ts-p-21467.html

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#13 Logic

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Posted 15 May 2013 - 11:30 AM

This looks more truthful: http://www.talkanabo...-truth.-6108447





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