29 replies to this topic

[socialpiranha]

I havent found much info regarding results with this drug so i will be posting my results daily starting tomorrow. anyone who has had experience with this medication please feel free to add your conclusions. The pharmacology has yet to be illucidated but is believed to involve the gabaergic system.

[socialpiranha]

took it last night, seemed to produce a very relaxing feeling fell asleep faster than usual. no noticable hangover effect like with benzos. seems to be a clean relaxant so far cautiously optimistic.

[Dinvestor]

Hey Social:

Thanks for the update. Let us know how you do. I've been looking at this one too...

D

[socialpiranha]

hey D , day 2 dosed in a.m no noticable effect on social functioning, slight increase in motivation but could be due to other factors. studies suggest gabaergic changes take two weeks to fully manifest so will keep going and maintaining this log .

[socialpiranha]

not noticing enough to continue

[Dinvestor]

Bummer, did you not get any anxiety relief at all?

[socialpiranha]

Bummer, did you not get any anxiety relief at all?

the usual questionable placebo effect then nothing...i cant continue more than a few days without noticing at least i tiny amount of relief. i've tried so many things that didn't end up working that i lose hope more quickly than i'd like to.

[Dinvestor]

Yes, I feel your pain...been there as well. currently trying Afobazole and haven't felt much yet. It says it can take up to 4 weeks and I'm at 4 days. so we'll see...

[socialpiranha]

I went two weeks on afobazole and noticed some negatives so i stopped, it has some novel actions though like sigma agonism so it may just happen to be exactly what you need hope it works!

[Dinvestor]

Hey SP:

What were some of your negatives and what is sigma agonism?

I'm just trying to calm my brain, basically which always seems to be on hyper alert...more of an anticipatory anxiety as I've had some severe panic attacks in the past due to late stage Lyme Disease. Benzo's work great, and I rarely take them unless over stimed or on the verge of panic, which is not that often...but, the anticipatory stuff drives me nuts.

[socialpiranha]

the sigma receptor is an opioid receptor i believe, afobazole is an agonist at this receptor. The side effects were hard to describe, i just felt off like i wasnt myself. Everyones anxiety is different though and caused by different combinations of things going on in the brain. i'm guessing we have similar biochemistry tho because thats what my anxiety is like, I have had severe panic attacks in the past and developed an anticipatory anxiety disorder because of it. my panic attacks started when i was 13 soon after i smoked pot for the first time. Ive had several ticks in me and was tested for lyme because the ticks in my area carry it, in fact my grandfather got it from a tick.its a strange disease with strange symptoms seems like the medical community really doesnt know a whole lot about it from what ive read.

Are you trying to find a safer alternative to benzos? You might look into etifoxine if thats the case, it works similarly to a benzo and actually repairs peripheral nerves which might be helpful for lyme disease. its a bit less effective than benzos but it definitely helps.

[Dinvestor]

Thanks for the info. I'll have to look at etifoxine. Yes, I've dealt with Lyme for 17 years and there are not many MD's that know how to treat it. Took 7 years for me to be dx'd. I could probably get my MD for what I've learned over the years from it.

Definitely attacked my neuro system and I mainly deal with anxiety and nasty migraines a couple times a week. Benzo's help with the anxiety, but do nothing for the migraines. I've run the gambit of both pharm and nutra to try to find relief and have not had much success. That's why I've been messing a bit with the russian stuff...most of which seems pretty tame so far.

I've tried Ladasten, and now Afo and we'll see. I actually got some Validol from Awake Brain and that stuff does calm my system down, in fact it makes me pretty drowsy, which I'm not really looking for. Anyway, still trying.

Have you had any experience with Tofisopam or Mexidol?

Great chatting with you!

[Dinvestor]

Yes, I'm looking for something I can take everyday to take the edge off and then keep the benzo (Klonopin) as a backup in case I have a severe attack. It would also be nice if what I took everyday for the anxiety would help curb the migraines. That's my ultimate goal in all this, without the toxic effects of course.

So, currently trying Afobazole and if that doesn't help, maybe on to etifoxine or Mebicar, or tofisopam, or Mexidol. Praying something fills the bill!

[lourdaud]

So, currently trying Afobazole and if that doesn't help, maybe on to etifoxine or Mebicar, or tofisopam, or Mexidol. Praying something fills the bill!

From where are you planning on buying that stuff if I may ask?

[Dinvestor]

Awakebrain is a great resource for Afo and Mexidol. The others I would recommend a web search. there's some intl pharmacies that carry them, but I can't say how good they are...

[socialpiranha]

Thats funny, i just ordered mexidol from awakebrain over the weekend, what did you think of bromantane(ladasten) i tried it and couldnt quite tell if it was doing anything.
I tried tofisopam it actually overstimulated me. its a phosphodiesterase 10 inhibitor and increases cyclic amp levels which is stimulative. it made me really panicky and more aware of sensations around my heart plus some akathisia. I used to get migraines tried all the triptans etc nothing worked, other than propranolol which made me tired and depressed. Have you tried hydergine i've talked to a few ppl who rave about it for getting rid of migraines.

[Dinvestor]

Ah, akathesia...I get that every night and have never been able to figure out where it's coming from. I get it whether I'm taking something or not. I've always felt it's my keyed up body/mind trying to unwind. Lasts for a while and then subsides. I hate it!

I like ladasten a little, but if I take it on successive days it peters out and it's rather mild anyway. Triptans help me, but I hate taking them and do all I can to stay away unless the headache is a 9 or 10, which happens a good bit.

Never tried Hydergine...may have to check that out. Let me know how the Mexidol works out. Have you ever tried validol? I got some from awake and it does calm me down. The effects don't last that long, but it could be a panic abortive, which some people use it for...

[socialpiranha]

Yeah i get it every night too, the only thing that really helps is benzo's but they make it worse then next day/night so i only take them when i absolutely have to. I havent tried validol i should have added that to my order but i kinda figured it would be just like valerian root which i didnt like. I'll definitely let you know how mexidol works out !

[Dinvestor]

Wow, your the first guy that mentioned that! We must be dealing with a lot of the same stuff When I was a teen (53 now) I experimented with Psilocybin one time and had a monster panic attack...wonder if that did something permanent.

Anyway, I ordered some etifoxine to see if that can help take the edge off and I'll stay with the Bacopa, which does help my gut. I'm still trying the Afo, but still haven't noticed much except an increase in the visual issues I get...eye heaviness and discomfort, focusing issues, etc. Not sure it's from the Afo, but it does seem to increase about an hour after I take a dose...

Interestingly, Awake took Ladasten and Validol off his site...not sure why.

[socialpiranha]

I definitely think mushrooms and other psychedelics can intensify the experience of panic and fear and subsequently cause disturbed fear reactions in the future. Almost as if they expand the possible intensity of the physical experience of fear. I imagine it would be similar in someone who had been tortured or something, they would probably have an exaggerated fear response because the body has a new model to exploit. Not to mention the downstream effects of chronic adrenergic stimulation etc. I also think ppl who experience anxiety disorder just naturally(from birth) are capable of experiencing sensations more intensely. I think this can be the difference between depression and bipolar depression.

[Dinvestor]

Hey SP:

Any update on Mexidol?

[socialpiranha]

hey, too early to tell yet just started it yesterday. No negatives so far though. I'll start a thread about it and memoprove soon.

[Dinvestor]

Social:

Any update on Mexicol?

I'm currently trying Etifoxine and I can feel it a little. Certainly not as strong as a BDZ. However, when I take it with Zembrin one or the other really kicks in. It's actually a bit too strong that way but seems (so far) to really calm me...We'll see if it maintains...

D

[xks201]

socialpirana have you tried afobazole? I noticed absolutely nothing from it really. I also get tics (mild) that are basically like restless leg syndrome that last like one or two seconds when I am really excited. I can control them but it is I guess more of a tendency than anything.

[socialpiranha]

yeah same, xks201 i tried afobazole without any positive effects. I haven't had much success with russian stuff, with the exception of selank, it had a definite effect but was so expensive i could only try a few doses. Mexidol has a definite anxiolytic effect Dinvestor but i seem to be waking up feeling almost hung over.. i dunno i'll have to try to unravel the effects from other things im trying.

[Dinvestor]

Boy, I concur with social on the russian stuff. I've tried Afobazole, Ladasten, even Tenoten and haven't really felt much. Ladasten seemed to help a little, but also seems to peter out if I take it over several days. Also have been trying Etifoxine and haven't felt too much...

Social, keep me updated on mex. I'm still working with Zembrin and will update...

[socialpiranha]

will do

[Dinvestor]

Hey Social:

How would you compare Mexidol to Etifoxine...and do you still take Etifoxine? I've been trying that and have not really noticed too much with it yet. The only thing, at the moment, that helps some seems to be the Zembrin, but I still may need to add something to it...

[socialpiranha]

i would compare them quite equally, they don't come anywhere near being an acceptable treatment but at least seem to differ from placebo. I am no longer taking either but i could see them being enough for other people. If etifoxine wasn't effective i wouldn't bother with mexidol its a fairly similar effect.

[Tommyboy101]

I have ADHD and believe the anxiety I have comes from that also...I heard if that is the case mebicar would be a good solution..however worried if its like Strattera in terms of over time decreasing pleasure in whatever you do...I wouldn't want that and Strattera worked for my anxiety and attention but it made me a zombie like just didn't feel pleasure like I once did.