Hi all,
So after reading SocialPirahnna's JDTic group buy thread, I noticed talk of Hesperidin being used in place of JDTic for it's action on the Kappa receptor because of how much cheaper it is. Naturally, when I heard that you can dose this by eating lemon peels, I was sceptical at best... I am now 100% certain that it has a significant effect on the Kappa receptors.
For the past month or so I have been trying to quit using opiates; I have been weaning my dosage down for weeks. Yesterday I took some morphine around 3 oclock, and was still pretty sedated when I took the Hesperidin around 5. From reading the thread, I expected that the Hesperidin would put me to sleep (one full lemon peel). This - however - was not the case at all.
Within an hour of eating the lemon peel, all my sedation was gone, and I was suddenly in a very good mood, light on my feet, and everything around me felt more lucid then I remember in quite a while. In short, it seems that the Hesperidin antagonized my Kappa receptors (removing all the sedation of the morphine in my bloodstream), and actually provided me with a potent energizing and anti-depressant effect.
I thought Hesperidin was supposed to be an Agonist for KOR?? :S Can partial weak agonists in small doses act like antagonists or something? This was a fairly profound effect. Could this have been from other chemicals in the lemon peel? Thanks.