Tom_, I have indeed heard that venlafaxine is a potent anti-depressant, but I have read far too many reports of horrid withdrawals:
http://www.steadyhea...tml<br /><br />http://www.wisegeek....out<br /><br />http://www.effexorla...om/<br /><br />http://www.lawyersan...=79<br /><br />http://www.consumera...m/rx/wyeth.html... Among
many others. The consensus among many depression/anxiety forum participants at various sites indicates that Effexor's potent inhibition of the reuptake of both serotonin and norepinephrine is what may contribute to it having the worst reported withdrawals. I have heard that they can go on for a long time (dependent on dose and duration of treatment obviously). There have even been
multiple successful lawsuits against Pfitzer because of their negligence to warn prospective patients of the "Cessation Syndrome"; I have no doubt in my mind that they do this to secure lifetime customers - those greedy fucking pigs. Also, I have withdrawn from Cipralex/Lexapro twice before (cold turkey at 20mg) and barely felt bad at all, so I really believe that the severity of withdrawals varies
greatly among these meds (due most likely to binding affinity, selectivity, and half-life) Honestly, doesn't seem worth it IMO, but not saying that it's a useless medication at all, as it does seem effective at least.
Chemicalambrosia, tbh I am not sure which type I tried... I think it was Jameson brand St. Johns Wort (which is standardized to some certain percentage). I realize in retrospect that I probably generalized like crazy by simply saying it's ineffective, so I guess it is worth a second look.
Noos, I have never read about Chromium, so I will look into it. I have however tried SAMe; once while on 20mg escitalopram, and once on its own, each time for about 2-3 weeks continuously at 400mg. I seem to remember noticing a mood lift when it was on it's own, and on the contrary, I felt
very fucked up when I took it with the Cipralex... my symptoms at that time were similar to serotonin syndrome, and were
NOT pleasant, with a marked increase in anxiety. I remember SAMe being a little stimulative as well... perhaps I will give this one a second try at some point, as it definitely had a noticeable positive impact on it's own. This time however, I will wait until I have stopped my cipralex completely (which will be sooner then later as you are about to read).
Update:The more I read about atypical depression, the more MAOIs seem like the most promising treatment vector. Due to the food/med restrictions as well as the slim-to-none chance that I will get one perscribed however, I have decided to investigate this idea by taking a "natural" route; If I seem to respond well to natural MAOIs, then I will either continue treating myself with them indefinitely, or
maybe pursue a pharmaceutical option... I really do not believe that pharms are always the best way though, and will do what I can to stay relatively "All-Natural". I have narrowed my list of potentials down to the following after a lot of research:
- Harmala alkaloids (via a "very" low dose of B Caapi tea)
- Rhodiola (through a reputable supplement)
- Ginko Baloba (same thing)
- Curcumin (probably by taking a curcumin extract like Curamed/Curamin, plus a 1/4 to 1/2 tsp of Black Pepper, as Piperadine has been shown to boost absorption by 2000% apparently
Since I still had a few capsules of Curamed (a high-quality extract of curcumin along with a few other herbs such as Boswellia), I decided I would try this tonight.
Let me begin by saying that I have tried this supplement many times before, and got next-to-no effects from it. This time though, I combined one capsule with a 1/4 tablespoon of black pepper, and the results have been quite apparent! To the point where I am probably going to buy another over-priced bottle of the stuff tomorrow. As of right now, I feel a little warm, my back ache is gone (was lingering all day), but most importantly, I feel almost lucid at the moment... Very relaxed,
content (best word to describe it), and just all around positive about things. Needless to say, I'm quite surprised!
Tomorrow I am going to take the same dose again in the morning, and then once again at lunch, both times on an empty stomach. I will update again with my results... there is actually a
lot of very good looking research on curcumin for a variety of ailments - depression and anxiety included. I am actually quite excited for this experimentation with these interesting natural MAOIs... wish me luck!