77 replies to this topic

[Vitalist]

I've tried MK-677, CJC-1295/dac, and BPC 157, each one more than once each, and bought from multiple vendors. Here's my take on these products:

 

MK-677 - I've bought this from 2 different vendors, product was identical in both cases. But I don't believe what's being sold as MK-677 is the same molecule described in the published studies. MK-677 is a "ghrelin like mimetic" and what people are getting likely *is* the much cheaper to manufacture ghrelin itself. What's being sold as MK-677 is probably all coming from the same lab in China, and then passed off as MK-677. The biggest clue: Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. I have yet to read a report by anyone that MK-677, when taken just before bed. improved their sleep quality. In my case it made it much worse and this seems to be a consistent finding for most people reporting their results. Conclusion: Most stuff being sold as MK-677 is fake. 

 

CJC-1295/with dac : I've purchased this 4 times iirc. Twice it was the real deal, and twice it was completely fake, bunk. When it worked the effects were noticeable, but effective dosing for any length of time will be expensive. Have no intention of buying this again. 

 

BPC-157: I've bought this twice and noticed nothing. I believe it was completely fake. If this product was really available at reasonable prices we'd be hearing a lot more about it since the research has been incredibly promising. But I've never come across any positive reports by actual users that couldn't be written off as placebo effect. 

 

Remember, this entire "Research Chemicals" business runs on the "honor" system. They all state very plainly that their products are not for human consumption. They can sell you anything they want and call it anything they want. 

 

I've never tried exogenous HGH and don't think it is necessary. For most people the pituitary gland does not lose its ability to produce GH, it's just that the signal to do so fades as we age. But fasting has proven to be a great booster of this GH production signal. A 24 hour fast will boost GH production by 1000% in men and 500% in women. These studies have been replicated. Why not go with what works?

 

 

 

 

[Nate-2004]

I've tried MK-677, CJC-1295/dac, and BPC 157, each one more than once each, and bought from multiple vendors. Here's my take on these products:

 

MK-677 - I've bought this from 2 different vendors, product was identical in both cases. But I don't believe what's being sold as MK-677 is the same molecule described in the published studies. MK-677 is a "ghrelin like mimetic" and what people are getting likely *is* the much cheaper to manufacture ghrelin itself. What's being sold as MK-677 is probably all coming from the same lab in China, and then passed off as MK-677. The biggest clue: Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. I have yet to read a report by anyone that MK-677, when taken just before bed. improved their sleep quality. In my case it made it much worse and this seems to be a consistent finding for most people reporting their results. Conclusion: Most stuff being sold as MK-677 is fake. 

 

Remember, this entire "Research Chemicals" business runs on the "honor" system. They all state very plainly that their products are not for human consumption. They can sell you anything they want and call it anything they want. 

 

I've never tried exogenous HGH and don't think it is necessary. For most people the pituitary gland does not lose its ability to produce GH, it's just that the signal to do so fades as we age. But fasting has proven to be a great booster of this GH production signal. A 24 hour fast will boost GH production by 1000% in men and 500% in women. These studies have been replicated. Why not go with what works?

 

Unfortunately I don't fast and couldn't. I'd kill people by the end of a day and couldn't function by lunch time.

 

My main concern here is MK-677 because I've bought it twice now, from two different vendors so far. Is it possible to lab test the stuff to be sure of its legitimacy? Has anyone tried this? Can I send it to a lab to test?

 

Personally as an aside, I think the FDA stands in the way of, rather than protects people from, getting the legit stuff of any kind online. By making substances inaccessible they make quality control impossible. It's the same with illicit drugs and other things the government bans. Colorado is a prime example of how quality improves when restrictions are removed.

[Rocket]

 

My main concern here is MK-677 because I've bought it twice now, from two different vendors so far. Is it possible to lab test the stuff to be sure of its legitimacy? Has anyone tried this? Can I send it to a lab to test?

 

 

Why not do a pre and post-blood test and see if the suppliers product is working? PrivateMD Labs is a good service and I think the test you would want to request is relatively inexpensive. I would be more curious about a product giving results. Would a chemical test of the substance even tell you if it was dosed 'as stated'? Go for the blood test!

[Vitalist]

Nate, I agree fasting is difficult. In the past 6 months I've done one 44 hour fast (was supposed to be 48 hours) and one 24 hour fast. This was much less than I had planned to do. 

 

But I do okay with intermittent fasting. I usually get in a couple of 14 to 16 hour fasts every week and I don't find this to be too hard. And GH doesn't suddenly spike after 24 hours of fasting, it ramps up over the time spent in a fasted state. So I believe you can get GH boosting benefits with intermittent fasting. 

 

[aconita]

About BPC157 I just started a cycle with a product that on paper is the very real thing (made in EU and same used in quite a few researches in PuMed), if I get the desired results I'll let you know, no room for placebo in my case guarantee.

 

About MK677 I have read more than a few people reporting improved sleep...possibly there is some bad quality around but it seems that there is legitimate stuff too, I am waiting for some to get here and I'll report my experience.

 

Testing HGH is not so easy and cheap because it is released in pulses, one every 2 hours, not all of the same amplitude and relatively short lived.

 

In order to test properly a blood sample has to taken every 2 hours for 24 hours....

 

HPLC is the way to test the compound itself which would be easier and more reliable for quality assessment but unfortunately I am afraid it is going to be quite expensive to do....unless one has a friend in a university biochemistry lab (in which case just let us know).

 

 

[Vitalist]

Aconita, I look forward to hearing how these products work out for you. 

[Nate-2004]

So reporting back. I got the sarmstore1 brand this time, which was $100 more than what that reddit guy charges and $100 more than the last place I got it which was Southern Sarms. 

 

It takes totally different. This one has more of an alcohol taste to it, slightly. The other one was bitter but didn't really taste like alcohol to me. 

 

I dunno what it's supposed to taste like but so far mk-677 has had a distinct taste on both occasions and neither have tasted exactly the same.

[aconita]

AFAIK taste doesn't mean much, MK677 in mesylate form is quite water soluble (but maybe harder to come by) while the base form isn't and requires usually alcohol or DMSO (or a mix of both), DMSO taste quite bitter.

 

MK677 comes from the producer in powder form, the seller usually makes the solution according to its preferences, nobody stops from adding some flavor to it, artificial vanilla cakes flavoring, for example (easy available in any grocery store).

 

DMSO likely provides the faster sublingual absorption but since MK677 seems to be well absorbed anyway it probably doesn't makes much of a difference in effectiveness.

 

Even the amount of MK677/solvent ratio varies from sellers, usually is 25mg/ml but for some brands is 50mg/ml, nothing stops from changing those ratios at will since MK677 seems not critical to get in solution. for sublingual use experience tells that a smaller amount (more concentrate) is easier to keep there til fully absorbed.

 

Mine would come in powder form and since I already have got both DMSO and ethyl alcohol (and vanilla flavoring ) I plan to make a 50:50 plus flavor at as much concentration as I can (just adding solvent til fully solute), It doesn't seem like much but 1ml sublingual is quite a lot to hold there for long enough.

 

I don't think price is necessarily a quality indicator, in China from producers it seems to go for about 25$/g including shipping (small quantities like 5-10g) and likely Us sellers are paying not more than that for it ...I mean there is ample margin of profit anyway.

[motorcitykid]

So reporting back. I got the sarmstore1 brand this time, which was $100 more than what that reddit guy charges and $100 more than the last place I got it which was Southern Sarms. 

 

It takes totally different. This one has more of an alcohol taste to it, slightly. The other one was bitter but didn't really taste like alcohol to me. 

 

I dunno what it's supposed to taste like but so far mk-677 has had a distinct taste on both occasions and neither have tasted exactly the same.

 

I know of two different people who swear by ISARMs for legit product:  https://www.isarms.com/forums/

https://www.isarms.com/

 

Good Luck!
 

[platypus]

I think it improves my sleep, but since it increases the length of sleep it can make one feel groggy in the morning. 

[Rocket]

About BPC157 I just started a cycle with a product that on paper is the very real thing (made in EU and same used in quite a few researches in PuMed), if I get the desired results I'll let you know, no room for placebo in my case guarantee.

 

About MK677 I have read more than a few people reporting improved sleep...possibly there is some bad quality around but it seems that there is legitimate stuff too, I am waiting for some to get here and I'll report my experience.

 

Testing HGH is not so easy and cheap because it is released in pulses, one every 2 hours, not all of the same amplitude and relatively short lived.

 

In order to test properly a blood sample has to taken every 2 hours for 24 hours....

 

HPLC is the way to test the compound itself which would be easier and more reliable for quality assessment but unfortunately I am afraid it is going to be quite expensive to do....unless one has a friend in a university biochemistry lab (in which case just let us know).

 

Point taken about the GH pulses.  But what is the half life of GH/IGF-1 It may be released in pulses but are blood levels fairly level for the most part? In which case there is reason to take a blood test.  I've seen other people post up blood tests while on MK677 and their values are higher than baseline pre-MK677.

 

If you use CJC1295 w/DAC the GH does not get released in pulses which means you can take a blood test whenever you want to.
 

[aribadabar]

It takes totally different. This one has more of an alcohol taste to it, slightly. The other one was bitter but didn't really taste like alcohol to me. 

My guess is one is in dissolved in Everclear/alcohol (nyles7's suggested method) while the other is in Carboxy-Methyl Cellulose solution (Southern sarms' pick for solvent) .

Edited by aribadabar, 15 December 2016 - 10:49 PM.

[kurdishfella]

Hgh for some has a bigger effect than on others even if both have the same levels, its about other things in dna how it reacts and works. Surpressed igf increase lifespan but your forgetting other hormones involvement and study was done on non humans which animals have different age spans and function

Edited by kurdishfella, 30 March 2021 - 06:16 AM.

[kurdishfella]

If you are growth stunted cus of unhealthy and take hgh once then youll see growth day 1 if its not too late

Edited by kurdishfella, 07 August 2021 - 11:14 AM.

[Jose White]

There is a useful site https://hgh-therapy-rx.com/ where everything is described in detail about HGH 

[jroseland]

Exogenous Growth Hormone supplementation can be one of the most powerful biohacks for muscle growth, youthful energy, and anti-aging but there's a dark side that must be accounted for...

Taking growth hormone has a detrimental effect on insulin sensitivity. Insulin resistance is highly problematic, Insulin is vital for your body to convert glucose into energy. A responsible growth hormone or SARMS user should add the cofactor Resveratrol.

 

 

Listen to podcast: Don't take Growth Hormone WITHOUT this Cofactor

[Rocket]

Exogenous Growth Hormone supplementation can be one of the most powerful biohacks for muscle growth, youthful energy, and anti-aging but there's a dark side that must be accounted for...
Taking growth hormone has a detrimental effect on insulin sensitivity. Insulin resistance is highly problematic, Insulin is vital for your body to convert glucose into energy. A responsible growth hormone or SARMS user should add the cofactor Resveratrol.



Listen to podcast: Don't take Growth Hormone WITHOUT this Cofactor

One word: dhea

[jroseland]

One word: dhea

How does it compare with other body building hacks?