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Group buy for novel anxiolytic. Research topic.

gaba alpha glutamate

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#1 Reformed-Redan

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Posted 30 September 2013 - 03:03 AM


Hey guys,

So, we've been through a couple of interesting group buys. However, I think we haven't gotten a group buy going for a very important compound that some of us could use. I don't think there is anything more crippling than rampant anxiety. I'm really tired with fighting with myself and hate the idea of taking a benzo to calm myself down and then become dependent on it. So, I want to devote this thread to looking into any novel and non-cognitively impairing compounds that could serve as great anxiolytics. Please post anything that you have or are researching and I'll personally spearhead a group buy for it. Thanks.
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#2 telight

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Posted 30 September 2013 - 03:58 AM

Bromantane looks interesting, both a stimulant and an anxiolytic with a very good safety profile: http://en.wikipedia....wiki/Bromantane

Although this is not a group buy candidate, It could be a good solution to the anxiety problem.
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#3 penisbreath

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Posted 30 September 2013 - 04:50 AM

definitely interested

#4 Reformed-Redan

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Posted 30 September 2013 - 05:07 AM

Bromantane looks interesting, both a stimulant and an anxiolytic with a very good safety profile: http://en.wikipedia....wiki/Bromantane

Although this is not a group buy candidate, It could be a good solution to the anxiety problem.

I've tried Bromantane. It was OK; but, not great.

#5 Reformed-Redan

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Posted 30 September 2013 - 05:11 AM

I really hope this thread doesnt fade away. As a side note I found quite an interesting compound, check:
https://en.wikipedia...i/Brexpiprazole

#6 penisbreath

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Posted 30 September 2013 - 10:01 AM

does anyone know what the legal status is re: ordering research chemicals, specifically in Australia?

#7 Deep Thought

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Posted 30 September 2013 - 10:24 AM

350 mg of phenibut three times daily works really well for me, and I've suffered from really bad social anxiety for many years. I only use it occasionaly.

BNDF activating compounds deserve a mention too. (Read the links below)
Noopept has been highly effective for me. (Activation of BDNF signalling?)

7,8-dihydroxyflavone:
Excerpt: ...7,8-dihydroxyflavone blocks the return of fear in female mice after extinction training, and thus represents a novel approach to treating fear-related anxiety disorders that are characterized by a resistance to extinction and increased propensity for renewal.

I'm not a medical scientist, but that looks like a novel approach to treating conditions such as social anxiety.

Activation of BDNF signaling prevents the return of fear in female mice.
http://www.ncbi.nlm....pubmed/23589089
Fear extinction and BDNF: translating animal models of PTSD to the clinic.
http://www.ncbi.nlm....pubmed/22530815

EDIT: To anyone thinking about using GABA agonists for treating anxiety - please be aware some, if not all of these compounds may cause withdrawal symptoms upon cessation, and oftentimes have secondary mechanisms in addition to being anxiolytic. Phenibut.

Edited by Deep Thought, 30 September 2013 - 10:38 AM.

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#8 gnappi

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Posted 30 September 2013 - 12:14 PM

The best and fast anxiolytic for me is oxytocin nasal spray. Five minutes after two shots in each nostril... :-D

#9 focus83

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Posted 30 September 2013 - 01:49 PM

I'm not sure if this was discussed on this board as I can't find the thread. But I recall there was a discussion about a benzo like pure anxiolytic which neither caused sedation, cognitive impairment, muscle relaxation nor any of the other non-anxiolytic effects that benzo have. The marketing rights were sold to a Japanese pharma company which subsequently decided to not put the drug on the market for unknown reasons. It's unclear whether or not the drug will remain in its current status. Anybody know which drug I am talking about?

EDIT:

Found it! It's called Emapunil.

http://en.wikipedia.org/wiki/Emapunil

http://www.longecity...hibitor/ (only one single post)

http://benzowithdraw...com/2012/10/07/

Edited by focus83, 30 September 2013 - 01:55 PM.


#10 Reformed-Redan

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Posted 30 September 2013 - 02:14 PM

I'm not sure if this was discussed on this board as I can't find the thread. But I recall there was a discussion about a benzo like pure anxiolytic which neither caused sedation, cognitive impairment, muscle relaxation nor any of the other non-anxiolytic effects that benzo have. The marketing rights were sold to a Japanese pharma company which subsequently decided to not put the drug on the market for unknown reasons. It's unclear whether or not the drug will remain in its current status. Anybody know which drug I am talking about?

EDIT:

Found it! It's called Emapunil.

http://en.wikipedia.org/wiki/Emapunil

http://www.longecity...hibitor/ (only one single post)

http://benzowithdraw...com/2012/10/07/

Good post, thanks. Worth looking to. Here are some I am interested in that have a broad range of positive effects associated with glutamate activity: mGluR2/3 Agonists mGluR5 NAMs

#11 Negentropy

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Posted 30 September 2013 - 05:11 PM

very interested in this; trying to alleviate anxiety without benzos as well - -

#12 uralsky

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Posted 01 October 2013 - 02:34 AM

Tofisopam
possesses anxiolytic properties but unlike other benzodiazepines it does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. Tofisopam is not reported as causing dependence to the same extent as other benzodiazepines

#13 3AlarmLampscooter

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Posted 08 October 2013 - 02:27 AM

I think oxytocin agonists are an interesting target. WAY-267,464 is highly selective and anxiolytic in mice.

Also on the non-RC side of things, I've found propranolol, afobazole and niacinamide to all be good non-benzo anxiolytics. Oxytocin also, but short acting as an anxiolytic. Buspirone to some degree, but less so.
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#14 Reformed-Redan

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Posted 08 October 2013 - 06:08 PM

Shameless bump.

#15 JPC16

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Posted 08 October 2013 - 06:37 PM

I'm not sure if this was discussed on this board as I can't find the thread. But I recall there was a discussion about a benzo like pure anxiolytic which neither caused sedation, cognitive impairment, muscle relaxation nor any of the other non-anxiolytic effects that benzo have. The marketing rights were sold to a Japanese pharma company which subsequently decided to not put the drug on the market for unknown reasons. It's unclear whether or not the drug will remain in its current status. Anybody know which drug I am talking about?

EDIT:

Found it! It's called Emapunil.

http://en.wikipedia.org/wiki/Emapunil

http://www.longecity...hibitor/ (only one single post)

http://benzowithdraw...com/2012/10/07/


Finally, someone read my post :-D .
I am definitely up for a group buy of Emapunil.

#16 n95

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Posted 10 October 2013 - 02:36 PM

Here's one: Cannabidiol - http://en.wikipedia....iki/Cannabidiol
and possibly another: Imidazenil - http://en.wikipedia....wiki/Imidazenil

#17 focus83

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Posted 10 October 2013 - 03:42 PM

I'm not sure if this was discussed on this board as I can't find the thread. But I recall there was a discussion about a benzo like pure anxiolytic which neither caused sedation, cognitive impairment, muscle relaxation nor any of the other non-anxiolytic effects that benzo have. The marketing rights were sold to a Japanese pharma company which subsequently decided to not put the drug on the market for unknown reasons. It's unclear whether or not the drug will remain in its current status. Anybody know which drug I am talking about?

EDIT:

Found it! It's called Emapunil.

http://en.wikipedia.org/wiki/Emapunil

http://www.longecity...hibitor/ (only one single post)

http://benzowithdraw...com/2012/10/07/

Good post, thanks. Worth looking to. Here are some I am interested in that have a broad range of positive effects associated with glutamate activity: mGluR2/3 Agonists mGluR5 NAMs


Sound very interesting! Can you maybe narrow down this selection? Which is your favorite compound? Based on what I read in the wiki entries, some of the compounds have undesirable side effects.

Tofisopam
possesses anxiolytic properties but unlike other benzodiazepines it does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. Tofisopam is not reported as causing dependence to the same extent as other benzodiazepines


Isn't Tofisopam already available on the market?

Here's one: Cannabidiol - http://en.wikipedia....iki/Cannabidiol
and possibly another: Imidazenil - http://en.wikipedia....wiki/Imidazenil


Imidazenil sounds like another top candidate. Good one.

Edited by focus83, 10 October 2013 - 03:45 PM.


#18 celebes

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Posted 11 October 2013 - 12:04 AM

Flesinoxan http://en.wikipedia....wiki/Flesinoxan has good research behind it. I wonder why it was discontinued? Appears to be available on Alibaba for what it's worth.

Edited by celebes, 11 October 2013 - 12:06 AM.


#19 mmats

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Posted 11 October 2013 - 01:54 AM

WAY-267,464
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#20 Reformed-Redan

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Posted 11 October 2013 - 02:58 AM

Glad I started this topic. Nice info all around. Can we all agree after doing some research on what compound we would all like synthesized and then all contribute to the group buy. All of you guys/gals above have first priority. I think this is a more important group buy than any other in terms of becoming more functional under duress of stress and anxiety.

So far I like Cannabidol the most. It has some really good effects all around; but, unfortunately its widely regulated. I'm wondering if a derivative could be found... I know the structure is easy to synthesize; but, would be a terrible hassle given its status. Might just get one of those medical marijuana cards and order some high CBD strain.

Next in order of interest for me would be mGluR2/3 Agonists PAM's, though they haven't had any strong results in terms of calming anxiety.

I'm afraid of trying anything with oxytocin. Most of the side effects are unknown and not well researched enough for me to feel comfortable ingesting a oxytocin agonist. Though, I'm pretty sure its probably one of the more potent anxiolytic compounds out there.

Benzo derivatives are all a turn off to me and would be very expensive to synthesize.

Flesinoxan looks really interesting; but, after trying to taper off Zoloft and some of the effects of buspirone are just a complete turn off. Least speak of the never ending brain zaps and ED.

Let's not loose hope. Exercise is still my best "drug" in my arsenal; but, the problem is serious enough for me that I need to rely on some non-cognitively impairing RC to solve this.

#21 Dinvestor

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Posted 11 October 2013 - 03:05 AM

Hey Yada:

Have you ever tried Oxytocin nasal spray? My local compounding pharmacy is promoting it and there was even a recent study showing its effectiveness for migraine (which I suffer from).

I had also started researching it as a potential anxiolytic. The trick is there was also a recent study that it made social anxiety worse...

D
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#22 celebes

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Posted 11 October 2013 - 05:34 AM

Flesinoxan looks really interesting; but, after trying to taper off Zoloft and some of the effects of buspirone are just a complete turn off. Least speak of the never ending brain zaps and ED.


Did you have a bad time with the combination or each separately?

#23 Reformed-Redan

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Posted 11 October 2013 - 06:04 AM

Flesinoxan looks really interesting; but, after trying to taper off Zoloft and some of the effects of buspirone are just a complete turn off. Least speak of the never ending brain zaps and ED.


Did you have a bad time with the combination or each separately?

Each separately.

#24 formergenius

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Posted 11 October 2013 - 06:35 PM

I'd be in for buying Emapunil and Imidazenil.

My suggestions: JDtic [user report] [Longecity thread], and Neuropeptide S [intranasal study in rats].
I had more in mind, but I forgot.. But I'll be sure to check in soon as I've gone through my browser history.

As for mGluR2/3 agonism.. weird, because BCI is studying antagonists at these receptors for treating MDD.
As for CBD: I bought it legally internationally.. so I don't get the regulated part. It's decent for anxiolysis, though it's not what I'm after.
In any case I don't see any merit in a group buy for CBD, as it is available already, although being quite expensive.

Also agreeing on the BDNF-raising front.. Though I can't really say I noticed anything from Noopept.

#25 Reformed-Redan

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Posted 13 October 2013 - 01:42 AM

Here is the answer:

Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study.

Bhattacharya SK, Ghosal S.

Source

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Abstract

Bacopa monniera Wettst. (syn. Herpestis monniera L.; Hindi - Brahmi) is classified in Ayurveda, the classical Indian system of medicine, as Medhyarasayana, a group of plant derived drugs used as nervine tonics to promote mental health and improve memory and intellect. Earlier experimental and clinical studies have demonstrated the memory-promoting action of the plant extracts and that of its active saponins, bacoside A and B. The present study was designed to investigate the anxiolytic activity of a standardized extract (bacoside A content 25.5 ± 0.8%) of B. monniera (BM), since the plant is used in Ayurveda in clinical conditions resembling the modern concept of anxiety disorders. The animal models used have been extensively validated as experimental models of anxiety and included the open-field, elevated plusmaze, social interaction and novelty-suppressed feeding latency tests in rats. BM was used at doses of 5, 10 and 20 mg/kg, p.o. and the results were compared with those elicited by lorazepam, a well known benzodiazepine anxiolytic, used at a dose of 0.5 mg/kg, i.p. BM produced a dose-related anxiolytic activity, qualitatively comparable to that of lorazepam, in all the test parameters. However, statistically significant results were elicited usually by the higher two doses of BM. BM did not produce any significant motor deficit, at the doses used, as was evidenced by using the rota-rod test. The findings correlate with the clinical use of the plant in Ayurveda. The advantage of B. monniera over the widely used benzodiazepine anxiolytics lies in the fact that it promotes cognition unlike the amnesic action of the latter.

http://www.ncbi.nlm.nih.gov/pubmed/23195757

#26 penisbreath

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Posted 13 October 2013 - 04:58 AM

I know there's another thread dedicated to Jdtic, but socialpiranha seems to have disappeared for the time being. if you didn't want to step on his toes, that's understandable, but otherwise I second formergenius's vote, as that's the compound I currently have the most interest in
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#27 3AlarmLampscooter

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Posted 13 October 2013 - 09:50 AM

FYI, CBD is not a controlled substance in the US.
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#28 n95

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Posted 13 October 2013 - 12:19 PM

I'd be in for buying Emapunil and Imidazenil.

My suggestions: JDtic [user report] [Longecity thread], and Neuropeptide S [intranasal study in rats].
I had more in mind, but I forgot.. But I'll be sure to check in soon as I've gone through my browser history.

As for mGluR2/3 agonism.. weird, because BCI is studying antagonists at these receptors for treating MDD.
As for CBD: I bought it legally internationally.. so I don't get the regulated part. It's decent for anxiolysis, though it's not what I'm after.
In any case I don't see any merit in a group buy for CBD, as it is available already, although being quite expensive.

Also agreeing on the BDNF-raising front.. Though I can't really say I noticed anything from Noopept.


Regarding CBD, because it is quite expensive there may be merit in group buy, you know, to get a better price perhaps, thus making it more accesible

A bit off topic but since I've seen it mentioned here... somewhere I read that baclofen raises oxytocin levels, I'll try and dig up some links

#29 formergenius

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Posted 24 October 2013 - 02:00 PM

So I couldn't really find what I thought I had in mind, but what about plain Allopregnanolone? Though Emapunil would still seem more interesting.

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#30 Introspecta

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Posted 24 October 2013 - 08:49 PM

i'm surprised no one has seemed intersted in Emapunil. I would like to look into this further. Anyone have anything else on it.





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