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Effects of Uridine on GABA & Take Mega Doses at 2 Grams Of Uridine a Day.

uridine gaba mega dose

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#1 NootKing

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Posted 30 October 2013 - 04:08 PM


Effect of Uridine on GABA and High Energy Phosphate Levels in Healthy Volunteers (Uridine-GABA)


On the dual basis of findings indicating GABA increases following acute and eight week SSRI/dopamine agonist administration and those indicating GABA-ergic effects following 14 day pyrimidine administration, the purpose of this study is to assess our following hypotheses:
  • Relative to placebo, an oral dose of 1g of uridine BID (Which Means twice a day) for seven days will increase brain GABA levels in a sample of healthy, unmedicated adult males;
  • Relative to placebo, an oral dose of 1g of uridine BID for seven days will increase NTP levels in a sample of healthy, unmedicated adult males; and
  • Brain GABA levels will be directly correlated to high energy phosphate levels in this sample of healthy, unmedicated adult males.

Study Type: Interventional Study Design: Allocation: Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor) Official Title: The Effect of Uridine on GABA and High Energy Phosphate Levels in Healthy Volunteers

Detailed Description:

Based on prior MRS studies by our group as well as the work of others, we hypothesize that oral administration of uridine will actuate an increase in brain gamma-amino butyric acid (GABA) levels, along with beta-nucleotide triphosphate (ß-NTP) levels, as compared with baseline. Our aim is to investigate this specific neuropharmacological effect and to demonstrate the suitability of a novel magnetic resonance spectroscopy protocol in so doing. Our rationale includes the consideration that the clinical utility of an intervention demonstrably effective in elevating brain GABA and high energy phosphate levels is broad, since lowered GABA and bioenergetic states are associated with a plurality of affective, anxiety, and substance use disorders.
On the dual basis of findings indicating GABA increases following acute and eight week SSRI/dopamine agonist administration and those noting GABA-ergic effects of 14 day pyrimidine administration, we hypothesize that an oral dose of 2g of uridine per day for seven days will increase brain GABA levels in a sample of healthy, unmedicated adult males. We also hypothesize that this 2g dose of uridine per day for 7 days will increase ß-NTP levels and, further, that the increase in GABA and high energy phosphate levels will be correlated. Of note, the phosphorylation of glutamic acid decarboxylase by ATP significantly increased the activity of this enzyme, which is reponsable for the synthesis of GABA. This choice of time period will allow a determination of time course to efficacy between the acute and extended ranges, and further, because therapeutic dosage levels of uridine have yet to be established, in this and future studies we hope to determine the optimal dosage at which uridine increases brain GABA and ß-NTP levels.

This may be why there is an anti - depressant effect, due to Uridine effecting GABA levels.
Any scientists or intelligent people in here wish to add their thoughts ?
Im not a scientist or a doctor so im not going to comment, im just sharing this infomation i found with you.

From this, i gathered that it is okay to experiment and take Mega Doses of Uridine, at 2 grams a day ?

Edited by DontGetHuslted, 30 October 2013 - 04:09 PM.

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#2 NootKing

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Posted 02 November 2013 - 04:57 AM

Original Study or Trial, Over at Clinical trials.GOV

http://clinicaltrial...udy/NCT01261260

Which i forgot to add in my first post.

Edited by NootKing, 02 November 2013 - 04:58 AM.


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#3 BasicBiO

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Posted 25 April 2019 - 05:02 PM

Interesting possibilities with this. 







Also tagged with one or more of these keywords: uridine, gaba, mega dose

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