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Resveratrol prevents stress-induced cognition impairments; a rat study

resveratrol rats in vivo

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#1 malbecman

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Posted 12 November 2013 - 04:58 PM


Further evidence of resveratrol's ability to affect different organ systems, looks like they went for the ip dosing, though.....



Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 31. pii: S0278-5846(13)00238-8. doi: 10.1016/j.pnpbp.2013.10.017. [Epub ahead of print]

Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats.

Liu D, Zhang Q, Gu J, Wang X, Xie K, Xian X, Wang J, Jiang H, Wang Z.


Source

Institute of Medical Psychology, Shandong University School of Medicine, 44#, Wenhua Xi Road, Jinan, Shandong 250012, PR China.


Abstract


Depression is one of the most common neuropsychiatric disorders and has been associated with impaired cognition, as well as causing neuroendocrine systems and brain proteins alterations. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressant-like effects. The aim of this study was to determine whether resveratrol administration influences chronic unpredictable mild stress (CUMS)-induced cognitive deficits and explores underlying mechanisms. The results showed that CUMS (5weeks) was effective in producing cognitive deficits in rats as indicated by Morris water maze and novel object recognition task. Additionally, CUMS exposure significantly elevated serum corticosterone levels and decreased BDNF levels in the prefrontal cortex (PFC) and hippocampus, accompanied by decreased phosphorylation of extracellular signal-regulated kinase (pERK) and cAMP response element-binding protein (pCREB). Chronic administration of resveratrol (80mg/kg, i.p., 5weeks) significantly prevented all these CUMS-induced behavioral and biochemical alterations. In conclusion, our study shows that resveratrol may be an effective therapeutic agent for cognitive disturbances as was seen within the stress model and its neuroprotective effect was mediated in part by normalizing serum corticosterone levels, up-regulating of the BDNF, pCREB and pERK levels.
© 2013.

KEYWORDS:

BDNF, Brain derived neurotrophic factor (BDNF), CREB, CUMS, Chronic unpredictable mild stress (CUMS), Cognitive deficits, ERK, HPA, MWM, Morris water maze, NORT, PFC, RT-PCR, Resveratrol, brain derived neurotrophic factor, cAMP response element-binding protein, chronic unpredictable mild stress, extracellular signal-regulated kinase, hypothalamic–pituitary–adrenal, novel object recognition task, prefrontal cortex, reverse transcription-polymerase chain reaction


PMID: 24184538

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Also tagged with one or more of these keywords: resveratrol, rats, in vivo

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