Phenylalanine without PKU should be totally fine. I've heard that DL-Phenylalanine helps with the production of endorphins and beta-enkephalins(endogenous opioids). I don't know if this applies to regular phenylalanine either or just the DL form. I haven't done much research into it admittedly. Phenylaline is the precursor for PEA in the body though.
PEA is actually in foods too, chocolate is a good source, although low dose PEA is so rapidly metabolized it won't exert a physiologically noticeable effect without supra-physiological doses which are enough to exceed your body's ability to metabolize it quickly enough. Hence, mega dosing.
I never took PEA with an MAO-B inhibitor, just by itself in high doses. Although this is kind of like using a jackhammer when you would really want a scalpel. =P The side effects are greater because it's really hard to achieve a desirable target dose since you're kinda taking enough to ensure it exceeds your metabolism capacity, so you end up with way more than you'd wand at once, and since it metabolizes so quickly, it's like the equivalent of injecting a large dose of stimulant because it hits so quick with all of the compound active immediately.
In animal experiments PEA is often used as a baseline model for anxiety, as in; it induces such a strong anxiety response they use it to test new medications for anxiety treatment or to evaluate side effects by comparison.
I was going to try it with DMSO though, in an attempt to make a transdermal application of PEA, but I would advise against trying this without being really safe about it, since it may be dangerous. Gotta shower first, clean the area and only use it in limbs from what I've read. It might not do much at all if anything, but the concern is with the DMSO, since it can bring anything on the skin right into the bloodstream. We'll see at some point.
I've heard you have to be careful with MAO-B inhibitors as some of them if you have too much, or take it for too long(and it builds up as a result), they stop being selective for MAO-B and start to inhibit MAO-A as well, which can easily become very dangerous.
Edited by HappyShoe, 06 April 2014 - 04:19 AM.