5 replies to this topic

[John Schloendorn]

Legendary Pharmaceuticals

Unfortunately, they are very uptight with info about how they're doing what they're doing, but their science board is legendary indeed, and their mission statement is sharp enough:

Developing Pharmaceutical and Gene Therapies To repair and reverse The pathological changes of aging For a Healthy Future

http://www.legendarypharma.com/

So who of you guys is involved with these guys ?

Edited by John Schloendorn, 16 June 2005 - 04:59 AM.

[caliban]

This post violates the posting rules ands would be edited or deleted.
[tung]

John, as we are still in trial mode:

- leave out personal comments in the first post (you can put them into a second post straight after)
- For a company profile, use the

Also, a tiny bit more of research might be good. They say on their website

Legendary Pharmaceuticals researchers are developing molecular interventions which restore the effectiveness of these subcellular energy and garbage disposal systems. Cells composed of undamaged molecules, and containing better lysosomes, proteasomes, and mitochondria, will function like younger cells, and support a younger-feeling, younger-functioning body.

In parallel, Legendary Pharmaceuticals is studying the age-related accumulation of damaged proteins outside of cells. Plaques of amyloid beta protein accumulate in the brain. They produce free radicals which may kill brain cells, causing senility and Alzheimer's disease. Other damage affects extracellular proteins throughout the body, such as collagen and elastin. Recycling of these proteins proceeds slowly; they are out of reach of proteasomes and lysomes. Over time, they are chemically altered by reactive chemicals and sugars, which form covalent adducts and crosslinks. Crosslinked and glycated extracellular proteins contribute to many pathologies of aging and diabetes, including atherosclerosis, heart disease, stiffness, kidney diseases, arthritis, and erectile dysfunction. We are studying several promising mechanisms for breaking these crosslinks, as well as drugs which quench reactive free-radicals before they can chemically damage the proteins.

So they are working on antioxidants and AGE breaker. If you check out Furber, that assumption would be strengthened.


Good call though, they were definetly missing. [thumb]

I don't mean to stand you up and I don't intend to micromanage this forum, but as we are still in the launch phase, I'd be nice if at least the leadership could agree on the rules.

[John Schloendorn]

Look I made the trunk! or newspaper or whatever it is thingy.

Ok ok, I'll actually say what I think: Are these guys doing medical bioremediation, yes or no [!]

[Mark Hamalainen]

Ok ok, I'll actually say what I think: Are these guys doing medical bioremediation, yes or no

As you say John, their site is very vague. If they are pursuing bioremediation it may be under wraps.... de Grey is on their scientific advisory board... so perhaps they are.

[Mind]

If they are working on an AGE-breaker, it is a garauteed profit bonanza!!! This area has the most promise for short term aging reversal and wide acceptance. I hope they are working on it.

[Mark Hamalainen]

Alteon has been working on AGE-breakers for some time. They seem to have some strong canditate drugs but if I recall they've been having trouble with patent issues... does anyone know more?