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"Peptide Bioregulators" from Russia...

peptide bioregulators epitalon epithalon khavinson

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#31 John2009

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Posted 15 March 2017 - 04:54 PM

I have pasted some questions I sent to IAS regarding the peptides below, The responses from IAS are shown in green. Note their response to question 4 below regarding the size of the peptides and statement that there is no possibility of the presence of prions. Do you guys agree ? Does anyone have experience with synthetic versus natural peptides ? With synthetic, prions would not be an issue. I read that pineal gland and thymus peptides might be best for general anti-aging.  

 

If peptide levels can be restored in specific organs, I wonder how long it will last & what controls the rate of decline ?

 

I found a site at https://www.peptidesstore.com where they say they will beat any price you find by 5%. I emailed them with questions about their company, response shown directly below. Has anyone purchased from this company before and were you satasified with the service ?

 

From Peptidesstore.com:

 

Our company (6 years) is based in Tallinn, Estonia, but the products to the U.S. are shipped from Moscow, Russia. We have been selling online since September, 2013. We have a direct affiliation with St. Petersburg Institute of Bioregulation and Gerontology (Professor Khavinson is its director) 
 
Shipping cost to the U.S. is 15 eur and delivery time is usually 2 weeks. 
 
Please read:
 
 
 
There are some other interesting articles here: https://peptidesstor.../blogs/articles
 

 

 
 
 
Respnose from IAS to my questions directly below:

 

http://khavinson.info/research/main-published

 

1.  I quickly looked at the Russian Professors website at the link directly above, (the professor who's research is behind the product) , but what is the best evidence for effectiveness and safety ? 

If you go on the IAS website for the Peptide Bioregulators, the article page lists a number of the Institutes and Professor Khavinson’s articles on the peptides, www.antiaging-systems.com/250-peptide-bioregulators, including summaries of clinical case studies, the role of peptides in nutrition and the safety of natural peptide bioregulators. There is also a list of their patents and published articles that can be found on PubMed.

 

2.  If the peptides are instructing DNA and cells, what if something goes wrong and it produces a mutation or cancer ? I don't know how likely that might be or if it could even happen at all ? Please comment.

The peptides developed by the Institute have a long scientific history and profound research has been conducted in many different laboratories and institutions, especially in regard to their safety. Their safety has been double confirmed, at the N.N. Petrov Research Institute of Oncology in particular in long-term animal experiment. Moreover, the peptide (in experiments) prevented development of spontaneous and induced malignant tumours. 
The Institute also adds that the peptides are completely toxicity free. Even no LD was found. The peptides cannot induce any mutations, just opposite, they regulate correct synthesis of protein in the cells.

 

3. How many people have used the product worldwide and for how long ? When was the product first sold on the market and how long has IAA been selling the product ?

Over 15 million people got peptides in total during 25 years. The first publications on peptides appeared in the 70-ies and they were primarily used in military medicine starting from late 80-ies - early 90-ies( medications Thymalin, Thymogen,  Epithalamin, Cortexin, etc)
The peptides we are talking about (Cytomaxes) originate from them. There was also a 15-year long published clinical study which was conducted at the Gerontological Institute of the Ukrainian Academy of Medical Sciences whose results (with respect to the WHO standards) showed
 the efficacy of peptides for the elderly whose mortality in the study group decreased almost twice.

IAS has been selling the Peptide Bioregulators™ for four years.

 

4. Is it important that the peptides are extracted from young animals ? It's probably not a problem with Testoluten, but if the peptides were extracted from brain or nervous system tissue, (As might be the case with other peptides sold under the same brand name)  I might be a little concerned about Prions and Mad Cow disease, but if the animals are grass fed then perhaps that would not be such an issue.  Please comment.  

First and foremost in this respect, is that molecular weight of these peptides is below 10 000 dt. It excludes every possibility of any prions presence.
Please find attached pdf’s of the certificates. 

 

5. Has anyone at IAA actually used this product ? Can you tell me their experiences ? How did it make them feel, did it increase energy, libido, better mood, etc. ?

Yes, a number of the peptides have been used by staff and family members of IAS staff, including the muscle, cartilage and thymus peptides. We have also had very positive feedback from our healthcare practitioner’s including the use of the brain peptide to treat bi-polar disorder and Glandokort for the Adrenal glands.

 

6. Can different peptides be taken at the same time, for example, testoluten, Ventfort® and Libidon®, (do they compete with each other as amino acids can)  or is it best to use one at a time ?

Yes, you may take a combination of peptides simultaneously but it is advised that they are all for treating the same condition rather than two or more different conditions. Thus Ventfort (blood) peptide is often recommended in combination with another peptide as it improves blood flow and so helps to improve the amount of the second peptide that reaches the targeted organ or gland. Taking the combination that you propose should not be an issue although if you are looking to treat the testes then Testoluten and Ventfort may be all that is required.

   

7. What type of quality control is employed when manufacturing the product and selecting the raw materials ? I do not know anything about Russia or what type of regulations they have, or what their quality standards are.

The manufacturing facility is GMP certified and the quality of the primary ingredient is covered by the attached certificates.

 

8. Is the structure of the specific regulators the same as those that occur in the body ? I am asking this since the peptides are extracted from animals. Does the peptide source determine how the human body responds to the peptides ?  

The peptides contained in the bodies of mammals are absolutely identical. The technological process of their extraction and purification provides their safety and non-specificity.
The human body recognizes the peptide as its own irrespective of the animal source and receives it as a signal to normalize the function of a respective organ due to improvement of protein synthesis.

 

I would appreciate any additional info you can provide about testoluten and these peptide products in general, I would like to learn all I can. I can just try the product and see if I feel and see results but the product is expensive, so I want to be reasonably certain I will feel or see some Positive affect If I use it. However, the big issue for me is to make sure the product is safe to use.   

The web page referred to above has a number of articles about the use of and benefits of the peptides. Please remember that over 15 million people have used these peptides in Russia and the former USSR, and that research into these peptides has not just been conducted in Russia but in the EU and USA as well.

 

When taking the peptides the aim is to be on a maintenance dose of 1 pack of 20 capsules for 10 days, (ie 2 capsules per day), every 4 to 6 months. However, when first taking the peptides an intensive or very intensive course of peptides may be required, depending upon the severity of the condition being treated. The intensive course is 2 capsules a day for 30 days and very intensive is 4 capsules a day for 30 days. After this a break of 4 to 6 weeks is normally allowed for to assess the effect of the peptides and then there may be a repeat course or a less intense course of peptides. The goal being to come down to the maintenance course dose.

 

PLEASE remember that all information provided by IAS is education information provided under IAS terms and conditions and that it does not replace the advice of your physician. Restrictions may apply in some countries and terms may change without notice.

Attached File  Analyse 5707 5327 30206.pdf   93.24KB   6 downloads

 

Attached File  30206 vet_20160331121932.pdf   208.34KB   6 downloads


Edited by John2009, 15 March 2017 - 05:05 PM.

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#32 MBF

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Posted 21 June 2017 - 02:21 AM

Tha's all great, but, you forgot one important question. How are those peptides going to be so effective used by oral route? I would like to hear a explanation from them. " the major glitches in the optimal utilization of therapeutic proteins and peptides by the oral route are their extensive hepatic first-pass metabolism, degradation in the gastrointestinal tract (presence of enzymes and pH-dependent factors), large molecular size and poor permeation. "

 


Edited by MBF, 21 June 2017 - 03:07 AM.


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#33 AlexCanada

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Posted 08 September 2017 - 06:19 PM

These are so expensive.  Have better sources been found? Are any sites willing to sell smaller portions or samples?   It feels like such a gamble to spend $60US dollars on any one of these. 

 

 


Edited by AlexCanada, 08 September 2017 - 06:20 PM.


#34 AlexCanada

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Posted 08 September 2017 - 06:22 PM

Peptide bioregulators are effective. I confirm that. Very good are komlex peptide bioregulators 'Made in Germany'. Here:
http://previtalica.com/index_en.html

 

 

Vitapept in there I am interested in.   But there are seemingly zero reviews available online.



#35 trying2survive

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Posted 07 February 2018 - 10:41 PM

can't find any vendors for Vitapept...



#36 JamesPaul

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Posted 17 March 2019 - 05:05 PM

Tha's all great, but, you forgot one important question. How are those peptides going to be so effective used by oral route? I would like to hear a explanation from them. " the major glitches in the optimal utilization of therapeutic proteins and peptides by the oral route are their extensive hepatic first-pass metabolism, degradation in the gastrointestinal tract (presence of enzymes and pH-dependent factors), large molecular size and poor permeation. "

 

It might be absorbed well sublingually.  Here is why I suspect that.  GHK-Cu is a small peptide that is present in larger amounts in the blood plasma of yourger people than in the blood plasma of older people.  One experimenter, Dave Asprey, injects himself with it, or was doing so when he wrote a blog post about it.  If interested, see his article at the following link:

https://blog.bulletp...-brain-and-body

GHK-Cu peptide is sold by 

https://www.limitles...om/shop/ghk-cu/

This page says "As a short 3 amino chain it should be easily absorbed sublingually."

I suspect that means that other small peptides would also be absorbed sublingually.

Note:  the same webpage also says "This product [GHK-Cu] is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement."

 

A U.S. company, Medix4Life, sells products they call "regulatory peptides".  They are also taken orally.  I have no experience with them.  Their products are sold only through practitioners.  You could find a practitioner from their online list at https://medix4life.com/. I know of one practitioner although I've never spoken with him.  You could ask him what his customers' experience is.  See

https://synergisticu...cell-activators

 



#37 Daniel Cooper

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Posted 26 March 2019 - 04:07 PM

It seems there is a tendency to want to make everything a liposomal formulation (I've been guilty of this myself), but why wouldn't liposomal encapsulation work as a method to get these peptides through the digestive tract intact and into the bloodstream?

 

 

 



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#38 VP.

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Posted 26 March 2019 - 05:35 PM

Repost but maybe we should wait for better data on bio peptides: 

Not ready for prime time.

We have intermediate results for the first 6 months of our epitalon mouse lifespan study, which we're presenting here. (Big thanks to our partners Ichor Therapeutics for making this possible.)

While the study is not complete, there does appear to be a difference between the treatment and control groups regarding lifespan thus far, as well as some of the other metrics of motor function.

Since this study is investigator-blinded, the two treatment arms are labeled Lifespan A and Lifespan B. However, the longer-lived lifespan arm (Lifespan B) is comparable to, not superior to, historical survival data for C57BL/6 mice, while the shorter-liived arm (Lifespan B) is shorter than historical survival data, which means that there's reason to be concerned that epitalon shortens, rather than lengthening, lifespan. Moreover, Lifespan B appears to be superior or equal to Lifespan A in all motor tests, so far, which is consistent with the hypothesis that the Lifespan A condition is non-beneficial.

However, this is still a highly preliminary guess.  More than 70% of the mice in both groups are still alive; the identity of each group is still blinded; and thus we'll have to wait for the completion of the study to get conclusive answers.

https://thelri.org/b...epitalon-study/

 






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