Despite all of the nootropics and stimulants I've tried, I never bothered with the prototypical piracetam. Last week I ordered some authentic Geratam and began to take it in varying amounts. I also have a fair amount of metadoxine that I ordered a while back. Alone both products do have an effect. Piracetam is rather mild and metadoxine does provide a lucid and anti-fatigue effect over a 1-2 hour period. But just today I discovered the combination of 2400 mg of Piracetam with 1000 mg of Metadoxine provides an extremely lucid mindset. I tried it around 5pm and as of now I still feel the effects. It manifests as high amounts of motivation (just cleaned parts of my apartment I've been putting off for months) and a clear mind that makes it easy to focus.
Pharmacologically, I could not say what is going on here. Both drugs share a pyroglutamate structure (metadoxine is a salt of vitamin B6 and pyroglutamic acid). I've read that pyroglutamic acid combines synergistically with racetams, but metadoxine research done recently for ADHD shows that metadoxine acts differently than its constituent vitamin B6 and pyroglutamic acid components. That is, it has been observed to be a 5-HT2B receptor antagonist.
If this combination is anything like metadoxine extended release (http://www.alcobra-p...roductID=142236), I can see why Alcobra is pursuing it for ADHD. I recommend others to try this out if they have metadoxine and piracetam on hand.