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FYI: Interesting new paper

resvertrol

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#1 geo12the

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Posted 06 June 2014 - 06:25 PM


J Neurosci. 2014 Jun 4;34(23):7862-7870.

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults.

Abstract

Dietary habits such as caloric restriction or nutrients that mimic these effects may exert beneficial effects on brain aging. The plant-derived polyphenol resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking. Here, we tested whether supplementation of resveratrol would enhance memory performance in older adults and addressed potential mechanisms underlying this effect. Twenty-three healthy overweight older individuals that successfully completed 26 weeks of resveratrol intake (200 mg/d) were pairwise matched to 23 participants that received placebo (total n = 46, 18 females, 50-75 years). Before and after the intervention/control period, subjects underwent memory tasks and neuroimaging to assess volume, microstructure, and functional connectivity (FC) of the hippocampus, a key region implicated in memory functions. In addition, anthropometry, glucose and lipid metabolism, inflammation, neurotrophic factors, and vascular parameters were assayed. We observed a significant effect of resveratrol on retention of words over 30 min compared with placebo (p = 0.038). In addition, resveratrol led to significant increases in hippocampal FC, decreases in glycated hemoglobin (HbA1c) and body fat, and increases in leptin compared with placebo (all p < 0.05). Increases in FC between the left posterior hippocampus and the medial prefrontal cortex correlated with increases in retention scores and with decreases in HbA1c (all p < 0.05). This study provides initial evidence that supplementary resveratrol improves memory performance in association with improved glucose metabolism and increased hippocampal FC in older adults. Our findings offer the basis for novel strategies to maintain brain health during aging.

 


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#2 Supierce

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Posted 07 June 2014 - 02:50 PM

Interesting indeed! Thank you! :)



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#3 niner

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Posted 08 June 2014 - 03:52 AM

Interesting paper, and with a dose of only 200mg.  Note, however, that all the subjects were overweight.  All the really good rodent results have been those with a high fat diet.  It doesn't do as much if diet is normal.



#4 malbecman

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Posted 09 June 2014 - 03:54 PM

 Ahh, you beat me to it.   This was the most interesting one as well in my usually PubMed "What's new" resveratrol search results.....

 

As Niner mentioned, one wonders whether resveratrol's best effects are in the overweight population.



#5 geo12the

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Posted 09 June 2014 - 05:04 PM

 

As Niner mentioned, one wonders whether resveratrol's best effects are in the overweight population.

 

Could be that its beneficial for everyone but the benefits are most visible in overweight people. 


Edited by geo12the, 09 June 2014 - 05:05 PM.


#6 tunt01

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Posted 09 June 2014 - 06:51 PM

Anyone have data/opinion/guess as to resveratrol's impact on very thin/aorexic people?  I'm thinking of those with hyper or close to a hypercortisolism in phenotype.  

 

It seems like resveratrol mediates metabolic abnormalities, without exactly procuring life extension in the average person.



#7 maxwatt

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Posted 19 June 2014 - 06:06 PM

Res modulates blood glucose for diabetics according tomany papers, but I can't recall any that specifically mentioned non-obese diabetics.



#8 Keizo

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Posted 12 August 2014 - 04:04 PM

Anyone have data/opinion/guess as to resveratrol's impact on very thin/aorexic people?  I'm thinking of those with hyper or close to a hypercortisolism in phenotype.  

 

It seems like resveratrol mediates metabolic abnormalities, without exactly procuring life extension in the average person.

I'm at the low end of average. 19.5-20 BMI or so. It used to be lower (18.5 maybe), but I drink some olive oil every day now, and eat a lot of butter with everything, and hopefully I'm gaining some muscle. I'm certainly a nervous type...

 

I just started using this stuff. 500mg (1day) caused low estrogen type symptoms. So I upped my D-vitamin and so forth, and now I take 150mg resv. This is day 3 on 150mg. I feel a lot better now than previous days; I expect further normalization.

(This is the stuff from the UK bulkpowders, which is apparently 99% pure.) There is some mild type of unpleasant caffeine feeling to it, but I don't know, it also feels similar to low dopamine (as per my experience with quitting low and high dose amphetamine use). But I just read estradiol might be important for dopamine function in the male brain, so I might be reading a lot into it.

Maybe, right now, it's just some muscle tension in my neck (a recurrent problem of mine) causing a slight brain-fog and feeling of unease (it certainly created tension in the hands). I think my hands and neck, if stretched, turn more red than normal.

 

My reason for using this is to increase testosterone. I plan on maybe moving up to 300-400mg (eventually), then after a couple of weeks take some blood tests. My serum testosterone was at 16 nmol/L or 460 ng/dl, a few months ago.

Otherwise I only supplement basic stuff like vitamins & minerals right now.


Edited by Keizo, 12 August 2014 - 04:07 PM.

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#9 geo12the

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Posted 12 August 2014 - 06:09 PM

 

 

It seems like resveratrol mediates metabolic abnormalities, without exactly procuring life extension in the average person.

 

I don't think we can conclude anything about its life extension proprieties in the average person. Studies suggest health benefits, how potential benefits translate into life extension is unknown, but maybe the health benefits would translate to longer and/or better life. We just don't know. But on the balance there is more experimental evidence suggesting health benefits for resveratrol than C60 which people are gobbling up here like there's no tomorrow.



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#10 Keizo

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Posted 30 August 2014 - 05:29 PM

Thought I should post this somewhere. So I now use 500mg Resveratrol 99%, and 200mg Quercetin. 

The energizing effect has decreased and it does not disturb my sleep, but decreasing it to a more normal level (6-8 hours). Easier waking up.

However I now have mild but noticeable acne all around my mouth (for the first time in 2-3 years). I am 23. No disturbing effects to speak of.

 

Possibly I have an easier time looking at people's faces, and I would say I feel more assertive and slightly blunted (and calmed) emotionally. More obvious is decreased fatigue still in effect. It probably helps with my asthma, just like artichoke extract did.

 

 


Edited by Keizo, 30 August 2014 - 05:30 PM.






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