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Question about the duration of effect of nootropic


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22 replies to this topic

#1 rhakshasa

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Posted 11 July 2005 - 04:29 AM


I've been wondering, do nootropics have "permanent effect" on the brain. If I start taking piracetam, then stop, will the effect of the drug fade. I'm saying this because I want to start taking some nootropics (not sure yet which one, I will do more research) and I want to make sure I won't have to constantly buy pills (as I am young and do not have a lot of money, and anyway I don't have a credit card to buy them off the net)

#2 LifeMirage

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Posted 11 July 2005 - 05:06 AM

I've been wondering, do nootropics have "permanent effect" on the brain.



Some when taken for 6-12 months make changes that can last for several years.......permanent is a long time.

If I start taking piracetam, then stop, will the effect of the drug fade.


The effect is never as strong as being on them....I am not aware of any compound that would not fade to some extend.

I'm saying this because I want to start taking some nootropics (not sure yet which one, I will do more research) and I want to make sure I won't have to constantly buy pills (as I am young and do not have a lot of money, and anyway I don't have a credit card to buy them off the net).


Most accept money orders or checks. I would recommend reading Nootropic Q/A for more info.

Yours In Health

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#3 rhakshasa

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Posted 11 July 2005 - 09:34 PM

Yeah well longtime or permanent is almost the same thing ;)
I've always been wondering is piracetem costy? (Or the more effective Aniracetam) Because like I said I don't have so much money but I'm still interested in paying a moderate price for it.

#4 LifeMirage

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Posted 11 July 2005 - 09:38 PM

Yeah well longtime or permanent is almost the same thing.


Permanent is forever, nootropics effects do not last forever.

I've always been wondering is piracetem costy? (Or the more effective thing that start with A and end with cetem, don't really remember the name) Because like I said I don't have so much money.


Piracetam is pretty cheap, I would try that first.

#5 rhakshasa

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Posted 11 July 2005 - 10:40 PM

could you provide me some link to cheap piracetam store? I would thanks you a lot for that.

#6 AaronCW

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Posted 14 July 2005 - 08:02 PM

Hello rhakshasa,

I am happy with the quality, prices, and service at Unique Nutrition and would be comfortable in endorsing the company. As LifeMirage indicated there are many sources available and the process of elimination involved in finding a good supplier can be painfull.

Cheers,
Rasputin

#7 Guest_da_sense_*

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Posted 14 July 2005 - 10:57 PM

Be sure to get piracetam as bulk powder. Unique nutritions one seems to be good for me

#8 rhakshasa

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Posted 15 July 2005 - 07:05 PM

Thanks, it look like a great site! I will try buying 700grams of piractem, but since I'm there. I'd be curious about knowing if there is any other cheap/effective nootropics that I could buy down from there. (I'm not saying I will take anything, but I'm looking for any suggestion)

#9 rhakshasa

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Posted 15 July 2005 - 07:14 PM

Also I'd like to know if I should take piracetem or it's other varient. (The other varient seems to require lot less material.)

#10 spider

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Posted 15 July 2005 - 11:04 PM

"Also I'd like to know if I should take piracetem or it's other varient. (The other varient seems to require lot less material.) " (rhakshasa)

Start with piracetam first and I strongly recommend to buy capsules or tablets; no bulkpowder, yet.

#11 Guest_da_sense_*

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Posted 16 July 2005 - 09:07 AM

rhakshasa as spider said start with piracetam first. If you don't want to mess with powders get it in capsules but it's more expensive. You can also check UNs hydergine and deprenyl as they seem to have lowest price on net.
I'm now a deprenyl "addicts", it changed my life more than all other supplements together. Stock up on deprenyl and start enjoying life :)

#12 lemon

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Posted 16 July 2005 - 10:04 PM

da_sense,

Like the dope, eh? Dopamine that is.

:)

For curiosity's sake, how much are you taking?

#13 Guest_da_sense_*

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Posted 17 July 2005 - 12:19 AM

Dope dope dopeeeee :)
I'm currently taking 4-5 mg per day, one day liquid (2mg morning, 2mg afternoon) one day tablet (5mg morning), and i skip it on sunday.

So far I find this best supplement ever. It's not miracle of course. But since I uped my dose from 1mg daily, i have much more motivation for all type of things. Stuff i've been delaying for months i finnished in days. I even lowered my dose of other nootropics and don't take them regulary as before, and still feel better. It's not like I'm on drugs. I do get tired in the afternoon and if i can i get a nap. Also my sleep is much better than before and i seem to need somewhat less of it. Any kind of depression (i've had some mild problems before) is simply nonexistant.
Those who are very motivated might not feel much from deprenyl, but maybe they will feel piracetam, pyritinol and such. For me piracetam, pyritnol and such didn't show even close effects as deprenyl.

#14 lemon

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Posted 17 July 2005 - 01:20 AM

Umm... could someone tell da_sence 5mg a day is a wee bit much of deprenyl? He seems to be having a bit of fun but unless he's... um like fighting alzheimers or is 60+, he shouldn't be gulping down 30mg a week...

[:o]

#15 Guest_da_sense_*

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Posted 17 July 2005 - 05:10 PM

Umm...lemon i did ask how much is too much before but in the end answer came as "take as much as you like".
Please take a look at
http://www.imminst.o...f=169&t=7067&s=

If you have better information regardin deprenyl please post there. I've been thinking of slowly cuting my dose to 3 mg per day and then 2 mg per day, and if i stay the way i am now then good...if not i guess i'll up the dose again :)
What's "assuring" me is that deprenyl was originally used for depression, and was given to young people as well.

#16 spider

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Posted 17 July 2005 - 06:53 PM

Don't worry da_sense, I think that the way you are deprenyl is very responsible. If you want to be extremely safe, you can always cycle it.

Today, I'm going to start with deprenyl for the very first time. I've decided to use about the same dosage as you do.

#17 mitkat

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Posted 17 July 2005 - 07:42 PM

where do you all grab deprenyl from?

#18 nuncle

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Posted 18 July 2005 - 05:06 AM

One point to note concerning deprenyl: if it's the attention-enhancing effects you're interested in, you really don't need to take a large dose (even 5 mg) of deprenyl every day. Deprenyl is an irreversible MAO-B inhibitor, meaning that the only way for the brain to raise MAO-B levels back to normal is to synthesize more of the enzyme. The half-life for that process is about 40 days. So potentially all you need to do to raise dopamine levels is take several mg once a week. Taking a higher (daily) dose isn't going to do much more--there are diminishing returns.

On the other hand, it's been suggested that the neuro-protective effects of deprenyl may work via non-dopaminergic channels. If that's the case, you'd probably need to take deprenyl every day to benefit. But note that the doses typically used in longevity studies in animal models are much higher than would be safe in humans without running the risk of the dreaded 'cheese effect' (because at high doses, deprenyl is no longer selective to MAO-B). The much-hyped rat studies that observed increases on the order of 20-50% in life span typically employed doses equivalent to about 30-100 mg / day in humans.

Bottom line: the dopaminergic effects of deprenyl probably don't require daily use, whereas the neuroprotective effects probably do, but may not have any substantial effects at 5 mg a day. That said, given that deprenyl _is_ used in much larger doses in animal models, often beginning at early ages, it's unlikely that 5 mg a day will have any adverse effect. But the jury's still out, and there's virtually no data on neuroprotective effects in healthy humans.

#19 nuncle

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Posted 18 July 2005 - 05:13 AM

I've been wondering, do nootropics have "permanent effect" on the brain.


Well, it's certainly possible. There's no one-size-fits-all answer. Every substance is different, but it's certainly conceivable that some substance might interact with your existing neurochemistry in an irreversible manner. Obviously, the higher the dose you take of a given substance, the larger the chance of a permanent change occurring. At a sufficient dose, any number of beneficial substances become neurotoxic. Moderation may be the key (quite frankly, the doses people on this board claim to take for some substances I would find frightening, personally).

That said, provided you don't overdo it, it's unlikely you'll experience any permanent adverse effects. Just don't assume that a drug that gives you a nice buzz at 1 mg is going to give you 10 times as nice a buzz at 10 times the dose! The dose-response curve for most nootropics is, unfortunately, non-linear.

#20 Guest_da_sense_*

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Posted 18 July 2005 - 08:44 AM

mitkat - uniquenutrition.net or check suppliers list in forum, but unique is by far the cheapest.

nuncle i really can't say which of deprenyls properties are working for me. I was taking 1-2mg daily for about a month, but i only noticed real effects when i uped my dose.

#21 spider

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Posted 18 July 2005 - 09:55 AM

"I was taking 1-2mg daily for about a month, but i only noticed real effects when i uped my dose. "
(da_sense)

Perhaps it takes about a month before you can notice any effects. What I'm trying to say is that perhaps if you hadn't uped your dosage, you would have experienced the same effects.

Nuncle, you seem to know quite a lot about biochemistry. Do you have a background in it?

#22 Guest_da_sense_*

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Posted 18 July 2005 - 11:43 AM

spider i was thinking the same thing, that's why i'll lower my dose slowly. Once I see things are not as good as before i'll return to previous dose. I'll experiment for a couple of more weeks.

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#23 spider

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Posted 18 July 2005 - 04:24 PM

"that's why i'll lower my dose slowly. Once I see things are not as good as before i'll return to previous dose. " (da_sense)

Yes, this is a good idea. [thumb]

"I'll experiment for a couple of more weeks. " (da_sense)

Wow, you have a lot of patience. This is the only problem I have with nootropics and brain supplements: TIME. I don't mind spending the money or accepting a little health risk, but finding the right nootropics for yourself takes a huge amount of time. For example, if you are a high school student who has serious problems with one's learning capability and therefore want to start experimenting with nootropics, than he/she has to experiment 1 to 2 years before he/she will know what works for him. So, I think everyone must realize that nootropics or brain supplements will not give you a QUICK solution to your problem.

Fortunately, by reading this forum carefully, one is able to cut back some time. :)




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