Well, I'm taking the Mg Threonate as well as some other Mg conjugates. I've never used adderall previous to this, but I have been seeing the effectiveness wain, I just went from 20mg/dose to 30... I haven't been getting high intensity workouts though... Perhaps it is preserving the health of my brain, but I'm not sure that I'm getting anything else, including cognitive benefits from the Mg Threo. I think the most important factor in preserving efficacy is getting a good nights sleep.
I'm thinking Adderall XR, high intensity training, 1-3 days off of it each week, and biphasic sleep (adderall stops working all together if you don't sleep enough, even with plenty of days off) might give better results and prevent tolerance. I'm about a week away from what I think will be the start of my 4th bottle? I'm not feeling addicted and making some good strides in forming more productive habits and getting rid of bad ones, but I might take some time off or try switching to a higher dose of Ritalin for a while and see what happens.
I've also realized that there is some connect between the higher cortical volumes associated with long term amphetamine use and Hyaluronic Acid (HA) supplementation. If you're taking supps to boost Klotho and taking HA, you may not see any additional benefit in this area, just a little more consistent performance/attention, a little more courage, and I'm able to listen to music or and read at the same time, or tune out more background noise without being being distracted by it which is probably the biggest benefit I'm seeing now.
I may not be making the most of it though for my goal, I tend to get more introspective and studious, and while I've also seen social benefits (my voice is bit stronger) I was hoping for a stronger social stimulant as that's where I need the most help keeping the pace up. I think the social apprehension side effect might be lower with dexedrine and might give that a try too. It's a psychosomatic side effect though... it happens b/c I put myself in more of the social situations that I usually avoid which means it's working to that end and I'm just not as socially proficient as I want to be yet. I am improving when off the drug and have even less apprehension than ever... Will be putting it all to the test soon.