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Why do triptans work against migraine?

triptans migraine experts

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#1 caliban

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Posted 07 August 2014 - 10:49 PM

...if regular painkillers have no effect at all? Why this thing about 'stopping' the attack while it develops? What's the MoA and (why) does it vary between the different types?

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#2 shp5

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Posted 09 February 2016 - 09:07 PM

No discussion here? I've been a migraine sufferer (aura, headaches, vomiting) for years and just now took my first triptan (2.5mg) Zolmitriptan and it seems to work like a charm. I cannot express how relieved I am.


Wiki proposes that Triptans are Serotonin receptor agonists, thus inducing vasoconstriction and reducing the release of inflammatory peptides. My question: Is there a danger that triptans lose their effectivness with repeated use, and how could you prevent that? Would it make sense to alternate different triptans?

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