3 replies to this topic

[eon]

Upon reading this article, where can I buy, if available for purchase, the compound P7C3?

 

http://medicalxpress...tic-injury.html

 

Also, there was a mention of NAD in the article. I would have to re-read the article again so I can figure out what it is trying to say. I think it is saying with the use of P7C3 the NAD level will be preserved. Since the P7C3 compound may be hard to find, would taking just NAD be helpful in traumatic brain injury (tbi). The article just didn't mentioned it so but that is my take on the article is that NAD is proven and great, so why the use of P7C3? To simply preserve NAD levels?

[graatch]

It's referring to an activity of binding NAMPT, an enzyme which rate-limits the conversion of nicotinamide to active NAD. So when in tests the animals are treated with a substance that causes NAD depletion, like doxorubicin, NAD levels are restored and the consequent doxorubicin neurotoxicity is reduced. While the papers talking about this effect were not using healthy animals, since the rate-limiting enzyme is active generally not just with disease or damage or doxorubicin, it seems a very strong bet that NAD is increased for healthy persons also. Many people here know much more about NAD chemistry than me, so I'll leave the discussion to others about whether this would be desirable in every case or chronically.

[nickthird]

I want to hear more about this...

 

What are the expected effects if you don't have brain damage?

[Infinite1]

You might wish to check out a product called Synapsin. Yes, it sounds a bit trademarked however it may offer you some similar benefits, offering nicotinamide riboside in a nasal spray, with a good amount of research for your particular application. Most compounding/specialty pharmacies will still require a prescription, however any sympathetic MD should be willing. Wow! I guess this is reviving a thread long past. 

 

https://www.pavilion...imers-disease/ 

Edited by Infinite1, 16 October 2019 - 01:57 AM.