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First published way to double mammal lifespan


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#1 treonsverdery

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Posted 30 July 2005 - 02:38 AM


The first published version of a lifespan doubling technology is described at http://www.vrp.com/art/1083.asp Dr. Max Odens conducted a study with ten 750-day-old rats, of a species that had a normal lifespan of 800-900 days. Five rats were untreated controls. The other five received weekly injections of “DNA solution in water…plus ordinary RNA.” Unfortunately, details of the exact composition and dosage that was administered were not given. After twelve weeks of injections, Odens reported that the treated rats looked younger, were very lively, and had gained weight, in contrast to the untreated rats which “looked old, moved slowly, did not eat much, and had lost weight. The difference was remarkable.” Odens further reported that all of the untreated rats died before 900 days, while 4 of the treated rats survived between 1600 and 1900 days, and one rat lived 2250 days! Odens concluded that “with weekly injections of DNA and RNA, the life span of 4 rats was doubled on the average, and the life span of the fifth rat was more than trebled.” These results are frankly, hard to believe. But some credence must be given this report, considering the journal in which it was published—the prestigious Journal of the American Geriatrics Society

Here are my thoughts

Replicate the study.

Hype: With an artificial heart you live a few years longer With a GIG your lifespan doubles.

The first journal published reference I'm aware of where a mammals lifespan was doubled was IV RNA plan: reproduce the result. New technology: GI resections are well developed technology. A GI Graft that contains a shunt to a major vein would allow humans to swallow magnetic or surface treated pills, that then linger n release at the GIG, then the GIG delivers a very high concentration of medication to the bloodstream. Useful with a variety of medications creating a laproscopic or endoscopic surgery to place the GIG is beneficial. GIG a surgery, with medication that doubles lifespan Vast numbers of people would double their lifespan with pills, few with IV. GIG allows IV to be replaced with pills.

Giving rats IV RNA to double their lifespan is like giving people IV ebay. There's a lot of stuff there, The car, house, food, electronics are useful but what about the RNA videos, beanie babies, garments, n memorabilia. small interfering RNA siRNA are drugs of their own. A wide variety of RNA application theories are testable with daphnia or artemesia: just common repeats, rare sequences only, amino acid ratios, mRNA, tRNA, High diffusion rate short non siRNA, RNA sequences produced with the most common RNAses, RNA sequences produced with rare RNAses. Vastly more ideas are possible. Each of these has possible merit to equal or better the published lifespan doubling with what the author called ordinary RNA.

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#2 Mark Hamalainen

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Posted 30 July 2005 - 04:04 AM

You've been fooled if you actually take any of this seriously. Nucleotide supplemntation does not double mammal lifespan even in the highly questionable references you have put forward.

There is a great deal of information available in the Bioscience forum here at ImmInst on real anti-aging science. ImmInst has also published a book on the topic which you should be receiving a copy of. I recommend that you review these information sources, as well as others such as Aubrey de Grey's SENS website.

Click HERE to rent this BIOSCIENCE adspot to support LongeCity (this will replace the google ad above).

#3 treonsverdery

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Posted 30 July 2005 - 04:42 AM

I will read the archives. There are numerous things that replication studies will benefit greatly. This Odens thing from Journal of the American Geriatrics Society
is first to my mind. I looked on medline briefly but did not find published material to support or refute.

A few old studies I'd like to hear replicated:
centrophenoxine 30 pt lifespan + one study
Pantothenic acid near 30 pt lifespan +

The wildly dubious deprenyl lifespan 20 or 30 pt + from a rare Romanian Journal with just 8 rats was replicated with Beagle dogs, at adequate n with a US researcher. That is a replication study I'm happy about.

I'm putting up a bunch of things as Imminst did an autopay on my membership n I quirkily feel like thinking of new ways to be immortal to work my membership. I have more fun with my "think of at least one or two new ways to be immortal every 24 hr" if I'm zany about it. I do appreciate the tension between zaniness n adequate science.

Happy you replied. If you have the time there's flaws everywhere on on the $200 prize page I'd like to address.

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#4 Mark Hamalainen

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Posted 30 July 2005 - 05:11 AM

I'm putting up a bunch of things as Imminst did an autopay on my membership n I quirkily feel like thinking of new ways to be immortal to work my membership


Unfortunately there are no quick fixes. Strategies based on diet/supplementation can effect the rate of aging (and all evidence suggests only very marginally), but cannot in any way bring about immortality.

Aging is understood already. We know what must be done, and it will take hard work. Talk of elixer's and potions only serves to confuse and distract.

Your enthusiasm and energy can be put to better purpose.




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