Seems counterproductive with respect to methionine restriction. Cysteine supplementation appears to reverse benefits of MetR in leanness and mitochondrial ROS production, while N-acetylcysteine supplementation reverses MetR effects on leanness (and I'm willing to bet, would abrogate mitochondrial ROS benefits as well)
Elshorbagy, A. K., Valdivia-Garcia, M., Mattocks, D. A., Plummer, J. D., Smith, A. D., Drevon, C. A., ... & Perrone, C. E. (2011). Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. Journal of lipid research,52(1), 104-112.
Perrone, C. E., Mattocks, D. A., Plummer, J. D., Chittur, S. V., Mohney, R., Vignola, K., ... & Orentreich, N. (2012). Genomic and metabolic responses to methionine-restricted and methionine-restricted, cysteine-supplemented diets in Fischer 344 rat inguinal adipose tissue, liver and quadriceps muscle. Journal of nutrigenetics and nutrigenomics, 5(3), 132.
Elshorbagy, A. K., Valdivia-Garcia, M., Mattocks, D. A., Plummer, J. D., Orentreich, D. S., Orentreich, N., ... & Perrone, C. E. (2013). Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance.Metabolism, 62(4), 509-517.
Gomez, A., Gomez, J., Torres, M. L., Naudi, A., Mota-Martorell, N., Pamplona, R., & Barja, G. (2015). Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction. Journal of Bioenergetics and Biomembranes, 1-10.
Notably, some of these researchers found fasting plasma total cysteine independently associated with BMI, with the highest quartile associated with a five-fold greater risk of childhood obesity. Rats fed more cysteine are fatter and more insulin resistant.
Elshorbagy, A. K., Valdivia-Garcia, M., Graham, I. M., Reis, R. P., Luis, A. S., Smith, A. D., & Refsum, H. (2012). The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins. Nutrition, Metabolism and Cardiovascular Diseases, 22(12), 1031-1038.
Elshorbagy, A. K., Valdivia-Garcia, M., Refsum, H., & Butte, N. (2012). The association of cysteine with obesity, inflammatory cytokines and insulin resistance in Hispanic children and adolescents. PloS one, 7(9), e44166
Elshorbagy, A. K., Church, C., Valdivia-Garcia, M., Smith, A. D., Refsum, H., & Cox, R. (2012). Dietary cystine level affects metabolic rate and glycaemic control in adult mice. The Journal of nutritional biochemistry, 23(4), 332-340.
Edited by Darryl, 24 March 2015 - 04:44 AM.