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Starvation (fasting) inhibits cancer

p53 starvation fasting starving cancer

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#1 Kalliste

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Posted 18 March 2015 - 09:13 AM


Always nice with a medicine that is free and accessible.

 

 

Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.
  1. Hong Seok Shim1,
  2. Min Wei2,
  3. Sebastian Brandhorst2, and
  4. Valter D Longo1,*

+ Author Affiliations

  1. 1Department of Biological Sciences, Davis School of Gerontology, University of Southern California
  2. 2Longevity Institute, University of Southern California
  1. * Corresponding Author:
    Valter D Longo, Department of Biological Sciences, Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA, 90089, Italy vlongo@usc.edu
Abstract

Short-term starvation or fasting can augment cancer treatment efficacy, but can also be effective in delaying cancer progression in the absence of chemotherapy. However, the underlying molecular mechanism remains elusive. REV1, a specialized DNA polymerase involved in DNA repair, has emerged as an essential component in genome maintenance and cancer development. Here we describe REV1 as an important signaling node linking nutrient sensing and metabolic control to cell fate. We show that REV1 is a novel binding partner of the tumor suppressor p53 and regulates its activity, and that short-term starvation facilitates the modifications of these proteins. Under starvation, REV1 is modified by SUMO2/3, resulting in consequent relief of REV1's inhibition of p53 and enhancing p53 activation, pro-apoptotic genes expression and in turn p53-mediated apoptosis in breast cancer and melanoma cells. Thus, fasting, through its effect on REV1, is a promising non-toxic strategy to increase p53-dependent cell death and to enhance the efficacy of cancer therapies.

 

http://cancerres.aac...N-14-2249.short



#2 Darryl

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Posted 19 March 2015 - 02:52 AM

Not a new idea.

 

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Longo, V. D., & Fontana, L. (2010). Calorie restriction and cancer prevention: metabolic and molecular mechanismsTrends in pharmacological sciences,31(2), 89-98.

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#3 Kalliste

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Posted 19 March 2015 - 05:34 AM

It's certainly no news in this corner of the internet. But official cancer-regulations still do not recognize this in many places. Sifting through the cancer-newspaper my job gets every week is pretty weird, they have several pages of recipes for milkshakes loaded with sugar and fat. Understandable in one way.







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