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Regenerative Mice


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#1 rodentman

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Posted 29 August 2005 - 05:30 AM


http://www.theaustra...5E30417,00.html

Ive been reading this article over and over again, and it almost sounds too unbeliveable.

2 things jump out at me:

When they injected fetal liver cells taken from those animals into ordinary mice, they too gained the power of regeneration. This makes a regenerative therapy very practical for all of us unlucky enough to not have these genes in our genome.

Also

The fact that they beleive that its almost certain that humans have the capabillity in our genes.

One thing that interests me would be, if we regrow an organ, would that organ have cells that are already aged.

RodentMan

#2 John Schloendorn

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Posted 29 August 2005 - 10:08 AM

SCIENTISTS have created "miracle mice"

For starters, MRL mice are an inbred lab strain like many others so I would not try to rise the impression of a planned "creation". The researchers themselves prefer to call it "discovered by serendipity" ;-) [1]

The fact that they beleive that its almost certain that humans have the capabillity in our genes.

Once we can actually "create" these mice, i.e. turn the regeneration response on in non-regenerating donor mouse stem cells, we might consider that possibility again ;-) There are no naturally occuring "regenerator" humans known, are they?

When they injected fetal liver cells taken from those animals into ordinary mice, they too gained the power of regeneration.

In some, but not other tissues [2]. This most likely reflects what type of stem cell participates in the regeneration of what tissue. I find this very interesting, perhaps one can one day make human applications of it. On the other hand, for the purpose of human rejuvenation therapy, one might alternatively want to regenerate our tissues from exogenous sources to fix all-types of age-related damage (see e.g. the infamous WILT). If one should end up choosing not delete telomere lengthening capability, but still to regenerate from exogenous sources (WILT "scaffold" without "proper"), then endogenous regeneration should make a cute addition. This gets us to your next question.

One thing that interests me would be, if we regrow an organ, would that organ have cells that are already aged.

Good thinking. As of today, there is no answer to that. If the organ came from few aged cells, then it would almost certainly carry some types of cell damage, but it these would almost certainly not be exactly the same types of cell damage that the organ would have if it had been around during all the time the cells have been around. We will know a bit more in a few months when the MRL longevity study comes to a close. My bet is they'll die from cancer (which is the usual cause of death of a lab mouse) perhaps slightly faster than others, but that's just a bet ;-)

Edited by John Schloendorn, 29 August 2005 - 10:42 AM.


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#3 manofsan

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Posted 29 September 2005 - 10:21 AM

Here's another article on the regenerative mice:

http://www.wired.com...html?tw=rss.TOP

Strange and wacky stuff. It's just odd that this was discovered serendipitously. Does this mean that this is a naturally occurring strain of mice which possesses regenerative capability? Or did the research group accidentally create some kind of regenerative ability while trying to modify the mice for other purposes?

#4 John Schloendorn

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Posted 29 September 2005 - 01:03 PM

It is a laboratory strain. They are "made" by decades of inbreeding until the mice are essentially syngenic (this is done to remove variance due to mixed genes from the experiments). As far as I am aware, no naturally occuring regeneratiors are known, and if they were found it would be very hard to know they were found, precisely because of the mixed genetic background that naturally occuring mice have. Naturally occuring mice do not make "strains". They mate with more or less anything that's got four legs and the right size. You may not find it satisfying, but this is all we can know about where these mice come from.

Btw, in her SENS2 talk, Ellen definitely confirmed that MRL mice have shorter life-expectancy, but it is not yet known if the regenerator phenotype when crossed into C57 (standard) mice will also confer shorter life-expectancy on them. As of now it may still be non-regeneration related MRL genes that confer the shortened life-expectancy. This is important because MRL are frequently used because of being prone to certain diseases.

She did not look at causes of death.

#5 kurdishfella

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Posted 19 January 2022 - 01:59 PM

quote: "It is a laboratory strain. They are "made" by decades of inbreeding until the mice are essentially syngenic (this is done to remove variance due to mixed genes from the experiments)"



Yes inbreeding you can make a feature more dominant this way so it can be used for good and bad. Like jewish people have higher Gaba levels than other caucasians similar as asians

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#6 sensei

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Posted 02 February 2022 - 11:13 PM

If the mice have a lower lifespan it may point to the involvement of MTOR. MTOR drives cell proliferation.

It may also point to systemic senescence. Apparently senescent cells are critical for wound healing so it would follow that if you can heal from wounds really well you have a lot of senescent cells which isn't a good thing for longevity
  • Ill informed x 2

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