18 replies to this topic

[mandible]

I'm confused.

I read there are studies that glycine might help with ocd. However in the book it said that patients took 60mg glycine and that

it wasn't tolerated well.

 

Now I ask myself what kind of glycine were they using? If they only took 60mg and didn't tolerate it then this would mean it can

impossibly be L-Glycine which can be bought as supplement and where people take 1 or more grams per day.

 

Any ideas? It would really frustrate me if I bought L-Glycine thinking it was the same stuff they used for ocd and in reality it is not.

[Area-1255]

The role of NMDA receptors in the signal attenuation rat model of obsessive–compulsive disorder

 

AUTHOR(S)

 

In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl- d-aspartate (NMDA) receptor in the pathophysiology of obsessive–compulsive disorder (OCD). To test the role of NMDA receptors in compulsive behavior using the signal attenuation rat model of OCD. In this model, ‘compulsive’ behavior is induced by attenuating a signal indicating that a lever-press response was effective in producing food. The NMDA antagonist, MK 801 (0.025–0.100 mg/kg) and the partial NMDA agonist, d-cycloserine (3–100 mg/kg) were administered to rats just before assessing their lever-press responding following signal attenuation (Experiments 1 and 2, respectively). Because the effects of signal attenuation are assessed under extinction conditions, drug doses that were effective in Experiments 1 and 2 were also tested in an extinction session of lever-press responding that was not preceded by signal attenuation (Experiment 3). Systemic administration of d-cycloserine (15 mg/kg) selectively decreased compulsive lever pressing, whereas systemic administration of MK 801 did not affect compulsive lever-pressing but dramatically increased resistance to extinction. Activation of NMDA receptors may have an anti-compulsive effect in OCD patients.

 

http://connection.eb...ulsive-disorder

http://www.ncbi.nlm....les/PMC3205262/

http://www.google.co...s/US20140011878

 

 

Activation of NMDA-glutamate pathways may help alleviate compulsions (repetitive behaviors), but not obsessions.

In other words, this treatment makes OCD more manageable. Try this : TEST FORCE II by e-PHARM nutrition (DAA + SARCOSINE), and do this WITH LEMON BALM extract and GOTU KOLA - I GUARANTEE THIS WILL ERADICATE YOUR OCD. Then NMDA is activated, and GABA is released and enhanced. The trick with OCD is you don't want more glutamate EVERYWHERE, YOU JUST WANT MORE GLUTAMATE AT OR MORE ACTIVATION AT THE NMDA RECEPTORS. You want less glutamate at the kainate and MB II receptors.

 

Edited by Area-1255, 01 May 2015 - 11:28 PM.

[ta5]

Maybe you're referring to this study. It was 60g not mg. Probably not tolerated well because it's a whopping high dose. I see some articles on the web that quoted the dose wrong. People often mix up g, mg, and mcg.

 

J Psychiatr Res. 2009 Mar;43(6):664-70. doi: 10.1016/j.jpsychires.2008.10.007. Epub 2008 Nov 30.

Adjunctive glycine in the treatment of obsessive-compulsive disorder in adults.

Greenberg WM1, Benedict MM, Doerfer J, Perrin M, Panek L, Cleveland WL, Javitt DC.

BACKGROUND:

Recent preclinical findings, case reports and non-blinded studies have suggested that glutamatergic interventions may be efficacious for Obsessive-Compulsive Disorder (OCD).

METHODS:

We enrolled 24 adult outpatients with OCD on stabilized treatment regimens in a double-blind trial of adjunctive glycine, an NMDA glutamate receptor agonist. Participants were randomly assigned 1:1 to either placebo or glycine titrated to 60g/day, with follow-up visits scheduled at 4, 8 and 12 weeks. Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was the principal outcome measure.

RESULTS:

Regimen non-adherence, principally related to complaints about the taste and/or nausea, resulted in only 14 individuals who were evaluable by predetermined criteria. Those receiving glycine (n=5) experienced a mean decrease of 6.04 points in Y-BOCS score, compared with a 1.00 point decrease for those receiving placebo (n=9). Using a hierarchical linear model, compared with placebo, individuals who received glycine had an average 0.82 decrease in Y-BOCS score for each week they remained in the study, not quite reaching statistical significance (p=0.053). Two of those receiving glycine were responders, versus none receiving placebo (p=0.11, ns, Fisher exact). Despite the dropouts, two participants were known to have subsequently continued taking glycine through their regular treating psychiatrist for over a year.

CONCLUSIONS:

The glycine condition approached efficacy for treatment of OCD in this study, with the high dropout rate related to problems with palatability and small sample size the principal caveats. This may indicate a new strategy for treatment of OCD, although confirmatory studies are clearly needed. (ClinicalTrials.gov NCT00405535.).

PMID: 19046587

 

 

[mandible]

I gotta check my book if it was indeed 60 grams then it would explain everything.

 

Anyway, I'm a bit confused now.

I thought that too much glutamate is generally bad for the brain.

Is this not so?

 

I was considering trying lamictal for depression and ocd cause it also affects glutamate.

 

@ area1255

 

Would this stack which you recommend also cure depression? Cause if not then it would be a problem cause I also have depression

and I doubt that this could be mixed with an antidepressant.

And I also have ADHD. This means I cannot take any supplements where I dont know if I can still take them with my prescription drugs. :(

[Area-1255]

Too much glutamate is collectively going to increase the risk of damage to brain cells, yes, but ...on the flip side, you need Some* glutamate for multiple brain functions :: Major executive functions; spatial functions, logical deduction...intellectual function...detail oriented function..everything cognitive, you need glutamate for. 

It's also NEEDED for immunity, for blood pressure regulation, for normal emotional expression
(too little glutamate diminishes emotional capacity), and for a multitude of cellular functions including the basic KREB cycle processis and manufacturing of energy within the cells (INTRACELLULAR)

Glutamate is also needed for ocular function, vision, hearing and critical in hormone responses.

 

 

 

 

 

I thought that too much glutamate is generally bad for the brain.

Is this not so?

 

I was considering trying lamictal for depression and ocd cause it also affects glutamate.

 

@ area1255

 

Would this stack which you recommend also cure depression? Cause if not then it would be a problem cause I also have depression

and I doubt that this could be mixed with an antidepressant.

And I also have ADHD. This means I cannot take any supplements where I dont know if I can still take them with my prescription drugs. :(

 

Edited by Area-1255, 02 May 2015 - 12:27 AM.

[mandible]

This seems pretty complicated.

 

I dont know if I have too high or too little glutamate. I rather assume too much cause of stress.

[Area-1255]

This seems pretty complicated.

 

I dont know if I have too high or too little glutamate. I rather assume too much cause of stress.

If you have too little, you would probably have one or many of the following symptoms.

 

• Insomnia.* (common)
• Apathy/Emotional Anhedonia
• Semi-Psychotic State or Compulsive State (frequent)
• Feel dependent on stimulants .
• Have issues with intellectual processing.
• Times of grandiosity and / or pathological narcissism. (depends on other factors and serotonin as well)
• Occasional episodes of delirium. (due to lack of glutamate control over sensory pathways)
• Impulsivity or passivity. 
• Night-Owlism. (due to finding peace at night and not due to work at night)
• Low libido/E.D**  (major sign of low glutamate)
• Memory Issues and Especially, clarity issues and racing thoughts. (could also be high glutamate)

[YosefANaumovich]

 Try this : TEST FORCE II by e-PHARM nutrition (DAA + SARCOSINE), and do this WITH LEMON BALM extract and GOTU KOLA - I GUARANTEE THIS WILL ERADICATE YOUR OCD. Then NMDA is activated, and GABA is released and enhanced. The trick with OCD is you don't want more glutamate EVERYWHERE, YOU JUST WANT MORE GLUTAMATE AT OR MORE ACTIVATION AT THE NMDA RECEPTORS. You want less glutamate at the kainate and MB II receptors.

 

I tried TestForce 2 and took the advised dosage (multiple grams of D-aspartic acid and sarcosine) with no noticeable effect on my testosterone, cognition or mood. 
For me, it could just as well have been sugar pills I was consuming - though at least sugar has a noticeable effect.
Even at the last scoop (i.e. after weeks of using it) I still did not notice any effect.

[Area-1255]

Well that's you, we are talking different person and different purpose, pal.

 

 Try this : TEST FORCE II by e-PHARM nutrition (DAA + SARCOSINE), and do this WITH LEMON BALM extract and GOTU KOLA - I GUARANTEE THIS WILL ERADICATE YOUR OCD. Then NMDA is activated, and GABA is released and enhanced. The trick with OCD is you don't want more glutamate EVERYWHERE, YOU JUST WANT MORE GLUTAMATE AT OR MORE ACTIVATION AT THE NMDA RECEPTORS. You want less glutamate at the kainate and MB II receptors.

 

I tried TestForce 2 and took the advised dosage (multiple grams of D-aspartic acid and sarcosine) with no noticeable effect on my testosterone, cognition or mood. 
For me, it could just as well have been sugar pills I was consuming - though at least sugar has a noticeable effect.
Even at the last scoop (i.e. after weeks of using it) I still did not notice any effect.

 

 

[YosefANaumovich]

 

Well that's you, we are talking different person and different purpose, pal.

I tried TestForce 2 and took the advised dosage (multiple grams of D-aspartic acid and sarcosine) with no noticeable effect on my testosterone, cognition or mood. 

For me, it could just as well have been sugar pills I was consuming - though at least sugar has a noticeable effect.
Even at the last scoop (i.e. after weeks of using it) I still did not notice any effect.

 

 

 

 

I should have mentioned that I do have some so-called "OCD" symptoms if a psychiatrist were to analyse my everyday behavior. Again, no effect whatsoever on that, either.

Is your tone condescending or is it just me?

[Area-1255]

I should have mentioned that I do have some so-called "OCD" symptoms if a psychiatrist were to analyse my everyday behavior. Again, no effect whatsoever on that, either.

I'm sure you do, but there's tons of people who have had great results from test force . 
 

Is your tone condescending or is it just me?

My tone is one hesitant to put too much stock in what you say, and it also seems that you have another agenda around here. 

You're also a snitch, and you like reporting people's posts. I also have an idea that you aren't who you say you are, and you aren't from the region you say in your profile. 

[YosefANaumovich]

 

I should have mentioned that I do have some so-called "OCD" symptoms if a psychiatrist were to analyse my everyday behavior. Again, no effect whatsoever on that, either.

I'm sure you do, but there's tons of people who have had great results from test force . 
 

Is your tone condescending or is it just me?

My tone is one hesitant to put too much stock in what you say, and it also seems that you have another agenda around here. 

You're also a snitch, and you like reporting people's posts. I also have an idea that you aren't who you say you are, and you aren't from the region you say in your profile. 

 

I find this behavior to be odd but it's clear that you're affiliated with the member I reported and want to get back at me for his sake.

 

As for my agenda - what is it? I came to the forum because I had read many posts prior to becoming a member and wanted the ability to respond. My first post I made was my attempt to help a member with the same problem as myself.

 

You're right. I reported the one drug addict (clearly your friend) who contacted me as I was a completely new user with almost no posts.
Why would someone contact a completely new user, asking them to buy a product for the questioner's own sake? Sounds like a drug addict trying to desperately exploit others.

That was the only report I have made on this website.

(Being the nice person I am, I've left his name out.

[Area-1255]

While I don't condone SPAM or nonsense, I find it alarming that you feel right deceiving someone. This behavior can be replicated, and furthermore, I wasn't aware of nor referring to that particular member.  I think you know what I was, truly, referring to. 

 

So go ahead , brag away. 

You could have just ignored him for the record, but thanks for once again confirming my point with an additional bit of evidence. 

I find this behavior to be odd but it's clear that you're affiliated with the member I reported and want to get back at me for his sake.

 

As for my agenda - what is it? I came to the forum because I had read many posts prior to becoming a member and wanted the ability to respond. My first post I made was my attempt to help a member with the same problem as myself.

 

You're right. I reported the one drug addict (clearly your friend) who contacted me as I was a completely new user with almost no posts.
Why would someone contact a completely new user, asking them to buy a product for the questioner's own sake? Sounds like a drug addict trying to desperately exploit others.

That was the only report I have made on this website.

(Being the nice person I am, I've left his name out.

 

 

 

[AMx Workshop]

reporting someone to get ahead is one most low lifely act i've heard of. you.are.a.fucking.idiot.

 

 

Is your tone condescending or is it just me?

My tone is one hesitant to put too much stock in what you say, and it also seems that you have another agenda around here. 

You're also a snitch, and you like reporting people's posts. I also have an idea that you aren't who you say you are, and you aren't from the region you say in your profile. 

 

I find this behavior to be odd but it's clear that you're affiliated with the member I reported and want to get back at me for his sake.

 

As for my agenda - what is it? I came to the forum because I had read many posts prior to becoming a member and wanted the ability to respond. My first post I made was my attempt to help a member with the same problem as myself.

 

You're right. I reported the one drug addict (clearly your friend) who contacted me as I was a completely new user with almost no posts.
Why would someone contact a completely new user, asking them to buy a product for the questioner's own sake? Sounds like a drug addict trying to desperately exploit others.

That was the only report I have made on this website.

(Being the nice person I am, I've left his name out.

 

 

[mandible]

@ area1255

 

I have some symptoms of this. I also think that I have ADD or at least many symptoms which fit to me.

 

• Insomnia.* (common) -> I have a hard time falling asleep
• Apathy/Emotional Anhedonia -> anhedonia yes
• Semi-Psychotic State or Compulsive State (frequent) -> OCD
• Feel dependent on stimulants . -> I take ritalin but i dont depend on it and i also dont think it does much for me
• Have issues with intellectual processing. -> yes I have this
• Times of grandiosity and / or pathological narcissism. (depends on other factors and serotonin as well) -> no
• Occasional episodes of delirium. (due to lack of glutamate control over sensory pathways) -> no
• Impulsivity or passivity. -> passivity very often
• Night-Owlism. (due to finding peace at night and not due to work at night) -> YES, I feel most peaceful at night but this is because this is the only time when i'm alone
• Low libido/E.D**  (major sign of low glutamate) -> low libido but not ED
• Memory Issues and Especially, clarity issues and racing thoughts. (could also be high glutamate) -> YES

 

So what do I do now? I rather lean towards too much glutamate.

 

And where do you get these symptoms like the night owl stuff? I mean where do you read that this is linked to glutamate?

 

[Area-1255]

@ area1255

 

I have some symptoms of this. I also think that I have ADD or at least many symptoms which fit to me.

 

• Insomnia.* (common) -> I have a hard time falling asleep
• Apathy/Emotional Anhedonia -> anhedonia yes
• Semi-Psychotic State or Compulsive State (frequent) -> OCD
• Feel dependent on stimulants . -> I take ritalin but i dont depend on it and i also dont think it does much for me
• Have issues with intellectual processing. -> yes I have this
• Times of grandiosity and / or pathological narcissism. (depends on other factors and serotonin as well) -> no
• Occasional episodes of delirium. (due to lack of glutamate control over sensory pathways) -> no
• Impulsivity or passivity. -> passivity very often
• Night-Owlism. (due to finding peace at night and not due to work at night) -> YES, I feel most peaceful at night but this is because this is the only time when i'm alone
• Low libido/E.D**  (major sign of low glutamate) -> low libido but not ED
• Memory Issues and Especially, clarity issues and racing thoughts. (could also be high glutamate) -> YES

 

So what do I do now? I rather lean towards too much glutamate.

 

And where do you get these symptoms like the night owl stuff? I mean where do you read that this is linked to glutamate?

It's just based on knowledge of how glutamate regulates circadian rhythms and impacts melatonin synthesis.

It's very possible that you have too much glutamate as well...do you have migraines or nausea frequently?

How do you respond to caffeine?

 

There's a lot to read, but here are some nice articles on it. It requires knowledge of terminology, though.

 

http://psyberspace.c...e/sanacora1.pdf

http://www.ncbi.nlm....les/PMC2880614/

http://www.ncbi.nlm..../pubmed/8957017

http://area1255.blog...a-receptor.html

http://www.area1255....g-value-of.html

 

 

 

Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

Yasutaka Mizoro,#1 Yoshiaki Yamaguchi,#1 Rena Kitazawa,2 Hiroyuki Yamada,1 Masahiro Matsuo,1 Jean-Michel Fustin,1 Masao Doi,1 and Hitoshi Okamura1,2,*

Shin Yamazaki, Editor

Author information ► Article notes ► Copyright and License information ►

 

Go to:

Abstract

The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR (N-methyl D-aspartate receptor) is well elucidated, much less is known about a role of AMPAR (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor) in circadian entrainment. Here we show that, in the mouse SCN, GluR2 and GluR4 AMPAR subtypes are abundantly expressed in the retinorecipient area. In vivo microinjection of AMPA in the SCN during the early subjective night phase-delays the behavioral rhythm. In the organotypic SCN slice culture, AMPA application induces phase-dependent phase-shifts of core-clock gene transcription rhythms. These data demonstrate that activation of AMPAR is capable of phase-shifting the circadian clock both in vivo and 

 

Edited by Area-1255, 03 May 2015 - 01:54 AM.

[mandible]

Hello,

my sleeping patterns change very often. Often I am up til 4AM and then sleep til 2PM.

Right now I go to bed a 11PM and get up at 10AM.

Usually I like being up late cause I like being alone at night and not being disturbed.

During the day I am bothered by too many things.

 

I have no migraines but I have visual snow 24/7 for over 10 years.

Sometimes when I close my eyes I also see dark circles which move closer towards me. I used to get this,too, when I had a cold or flu.

 

I drink 3-5 cups of coffee per day. What exactly should I look for when I drink coffee?

You mean wether it makes me feel worse?

Edited by mandible, 16 May 2015 - 12:29 PM.

[limonene]

To answer the OP. There is not really such a thing as "L-Glycine" or "D-Glycine" because Glycine is an achiral molecule. Glycine is just glycine, there is only one kind.
But it looks like some supplement manufacturers do label it "L-Glycine" probably because they are conflating it with the other amino acids which do indeed have L- and D- forms. So yes, you can safely assume that "L-Glycine" supplements are the same thing as "glycine".

[mandible]

thanks