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Smoking + Obesity accelerates aging


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#1 Lazarus Long

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Posted 11 September 2005 - 04:15 AM


Lots of research is now unraveling the aging as disease issue but doing so sort of ex post facto it seems. However in many respects (and this relates to a number of other environmental diseases) the causal mechanism can be understood as involving genetic mutation induced by these substances that disrupt and destroy normal cellular function. Rapidly we are approaching a new paradigm of disease based predominantly on genetics. This is analogous but even more profound than how the discovery of bacteria reorganized modern medicine IMHO.

http://news.bbc.co.u...lth/4219254.stm
Smoking 'harms key lung enzyme' 

Smoking appears to reduce a key enzyme in the lungs which helps regulate blood pressure, research suggests.
The researchers used sophisticated scans and a chemical tracer to show levels of the enzyme monoamine oxidase were 50% lower in the lungs of smokers.

It is thought that reduced levels of the enzyme could impair lung function, as well as blood pressure control.

The study, by the US government's Brookhaven National Laboratory, appears in the Journal of Nuclear Medicine.


http://news.bbc.co.u...lth/4086900.stm
Smoking and obesity 'age people' 

Being overweight and a smoker makes a person biologically older than slim non-smokers of the same birth age, UK and US researchers have found.

Smoking accelerated the ageing of key pieces of a person's DNA by about 4.6 years. For obesity it was nine years.

These genetic codes are important for regulating cell division and have been linked to age-related diseases.

The study in the Lancet was based on 1,122 twins from a database held by St Thomas' Hospital in London.






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