Can the activity of amphetamine be inhibited by an reuptake inhibitor, like an SRI(SSRI), NRI or an DRI?
From what i gathered, amphetamine works by acting the same way phenylethylamine (PEA) does,
which is by phosphorylating the reuptake enzyme,
and since there is some evidence that amphetamine increases extracellular activity of all three monoamines,
i would assume that it correlates with the fact that VMAT-2 handles all three monoamines, which by makes it assumable that amphetamine does handle all three monoamines, serotonin, norepinephrine and Dopamine.
VMAT-2 also handles GABA, which i'm not sure how it's effected by amphetamine, anyway.
So I'm thinking; could the synaptic activity of amphetamine be disrupted or even changed at all, by an reuptake inhibitor?
I mean, since the result of amphetamine is reversal, removal or inhibition of the reuptake enzymes, an reuptake inhibitor shouldn't negatively change the impact of amphetamine.
(And i know Amphetamine MoA is a little more complex, i just used it's PEA-TAAR1 activity as an example for correlation)