Is there any herbs, chemicals or nootropics that actually increase prefrontal activity?
Now i don't just mean the tiny change of activity that most herbs got, but an actual, possibly noticeable increase in prefrontal activity,
increased cognition, an increase in mood or improved executive functions is what I'm talking about.
Not what herbs most talked about do - a very small effect that most people doesn't even notice,
now i know that some if not most herbs have impressive activity based upon scientific studies, but due to some less than ideal problem,
lose their effectiveness before reaching the brain.
Take for example the herb 'berberine', it increases activity of all three monoamines, and interestingly, it increases activity of serotonin in the
prefrontal cortex and hippocampus by 29%, which is impressive, until you get to know that the herb has extremely low bioavailability at only 5%, and it reported to be even lower in mice (0,68%)..
So with other herbs having similar problems in one way or another, may it be bioavailability, blood-brain-barrier or other, it's not so many herbs and such that actually have a good effect..
So what I'm asking; Is there any herbs, chemicals and/or nootropics that actually increase activity in the prefrontal cortex?