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Salsalate (Aspirin relative) reverserses Tau-related Alzheimer's/Dementia

alzheimers dementia aspirin salicylic acid alzheimers disease tau

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#1 perceivethinkact

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Posted 25 September 2015 - 04:42 AM

EDIT: Can someone please correct the spelling on "reverses" in the topic title. That's embarrassing. 


Looks like a compound used for centuries (and also very similar molecularly to Aspirin ), Salsalate can stop and reverse tau-toxicity in the brain, in mice at least. Looks very promising. I've searched high and low to find a source for salsalate, but it looks to only be found at sources requiring prescriptions. Aspirin may have similar effects, but Salsalate is known for much less GI damage and platelet lowering. Any leads on where to source some?





Pertinent quotes:


"..."We identified for the first time a pharmacological approach that reverses all aspects of tau toxicity," says co-senior author Li Gan, PhD, an associate investigator at the Gladstone Institutes. "Remarkably, the profound protective effects of salsalate were achieved even though it was administered after disease onset, indicating that it may be an effective treatment option." Although tau has been a target in dementia research for some time, there are no tau-targeted drugs available for patients. Additionally, how the protein builds up in the brain, causing toxicity and contributing to disease, still remains largely a mystery. "





"...Notably, the dosage (225 mg/kg) used in our study is equivalent to ~1,350 mg per day for a 75-kg person[49], lower than the dose typically prescribed (3,000 mg per day). Our study supports clinical evaluation of SSA and its derivatives as therapies in human tauopathies."



Edited by perceivethinkact, 25 September 2015 - 04:45 AM.

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#2 Area-1255

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Posted 25 September 2015 - 04:55 AM

Not a big deal dude regarding the title; just don't make a habit out of it. lol

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Also tagged with one or more of these keywords: alzheimers, dementia, aspirin, salicylic acid, alzheimers disease, tau

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