Hi everyone,
I wanted to see if anyone knew about a good supplement regimen for someone with homozygous MTHFR C667T mutation and a COMT ++ mutation. My symptoms have been pretty consistently horrid over the years including lots of depression, anxiety and panic as well as really crippling brain fog.
The problem is that many of the things that help my depression will cause an increase in anxiety and things that help anxiety don't help the depression and slow me down even more. Supplements for methylation I have tried such as methylb12, methylfolate , TMG all caused a huge spike in anxiety. SAMe caused panic attacks but also blasted me off into some pretty serious mania followed by a crash to depression.
Currently I am on 20 mg of Brintellix and the addition of this has lowered my baseline anxiety enough to allow me to try some things that help my mood that used to cause intolerable anxiety but now its not as bad.
From what I have read the COMT ++ mutation will cause slowed degradation of dopamine which in turn either downregulates the receptors or acts as a negative feedback lowering PFC dopamine as the final result. My subjective feelings of zero drive, low libido, brain fog and inability to concentrate seem to get somewhat better if I take a stimulant or tyrosine. Other things that have helped are suniferam and pheynlpiracetam. I feel that none of these are very long term solutions and will just further impair dopamine levels through negative feedback.
I would greatly appreciate any advice or ideas on how to move forward with treating this.